CN104144708B - 基于脂质的纳米粒子 - Google Patents

基于脂质的纳米粒子 Download PDF

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Publication number
CN104144708B
CN104144708B CN201280017548.6A CN201280017548A CN104144708B CN 104144708 B CN104144708 B CN 104144708B CN 201280017548 A CN201280017548 A CN 201280017548A CN 104144708 B CN104144708 B CN 104144708B
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CN
China
Prior art keywords
liposome composition
lipid
imaging
formula
hydrophilic polymer
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280017548.6A
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English (en)
Chinese (zh)
Other versions
CN104144708A (zh
Inventor
A·安娜普拉戈达
J·L·艾瑞克森
E·A·塔尼夫姆
I·达斯格普塔
S·C·库克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
A Erzi Card Biological Science Co Ltd
System Board Of Directors Of University Of Houston
University of Texas System
Original Assignee
A Erzi Card Biological Science Co Ltd
System Board Of Directors Of University Of Houston
University of Texas System
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Application filed by A Erzi Card Biological Science Co Ltd, System Board Of Directors Of University Of Houston, University of Texas System filed Critical A Erzi Card Biological Science Co Ltd
Publication of CN104144708A publication Critical patent/CN104144708A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280017548.6A 2011-04-06 2012-04-06 基于脂质的纳米粒子 Expired - Fee Related CN104144708B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161472605P 2011-04-06 2011-04-06
US61/472,605 2011-04-06
PCT/US2012/032649 WO2012139080A2 (en) 2011-04-06 2012-04-06 Lipid-based nanoparticles

Publications (2)

Publication Number Publication Date
CN104144708A CN104144708A (zh) 2014-11-12
CN104144708B true CN104144708B (zh) 2017-07-28

Family

ID=46966277

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280017548.6A Expired - Fee Related CN104144708B (zh) 2011-04-06 2012-04-06 基于脂质的纳米粒子

Country Status (14)

Country Link
US (1) US9801957B2 (enExample)
EP (2) EP3366313A1 (enExample)
JP (3) JP6212032B2 (enExample)
KR (2) KR101973063B1 (enExample)
CN (1) CN104144708B (enExample)
AU (3) AU2012239888B9 (enExample)
BR (1) BR112013025633A2 (enExample)
CA (1) CA2831480C (enExample)
DK (1) DK2694116T3 (enExample)
ES (1) ES2685824T3 (enExample)
MX (1) MX357227B (enExample)
PL (1) PL2694116T3 (enExample)
PT (1) PT2694116T (enExample)
WO (1) WO2012139080A2 (enExample)

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PL2694116T3 (pl) 2011-04-06 2018-12-31 Board Of Regents Of The University Of Texas System Nanocząstki na bazie lipidów
MX366972B (es) 2012-01-20 2019-08-01 Ananth Annapragada Metodos y composiciones para caracterizar imagenes medicas en forma objetiva.
US9512092B2 (en) * 2013-12-12 2016-12-06 Albert Einstein College Of Medicine, Inc. Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof
AU2015330824A1 (en) * 2014-10-08 2017-05-25 Ananth Annapragada MRI imaging of amyloid plaque using liposomes
GB201509934D0 (en) 2015-06-08 2015-07-22 King S College London Nanoparticles
CN109414451B (zh) * 2016-05-16 2022-08-12 德克萨斯大学系统董事会 用于作为纳米粒递送tRNA的组合物及其使用方法
EP3548002B1 (en) 2016-11-30 2025-04-30 Texas Children's Hospital Hydrophilic fluorinated molecules for liposomal 19f mri probes with unique mr signatures
US20200261605A1 (en) * 2019-01-24 2020-08-20 Alzeca Biosciences, LLC Functionalized liposomes for imaging misfolded proteins
US11116854B2 (en) * 2020-01-29 2021-09-14 Texas Children's Hospital Targeted contrast agents for MRI of amyloid deposition
US11779664B2 (en) 2020-02-12 2023-10-10 Texas Children's Hospital Targeted contrast agents for MRI of alpha-synuclein deposition
KR20230012461A (ko) 2020-02-12 2023-01-26 텍사스 칠드런스 하스피탈 알파-시누클레인 침착의 mri를 위한 표적화된 조영제

Citations (1)

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Also Published As

Publication number Publication date
KR20190031334A (ko) 2019-03-25
JP6212032B2 (ja) 2017-10-18
US9801957B2 (en) 2017-10-31
AU2017232156C1 (en) 2019-10-24
AU2012239888B9 (en) 2017-10-12
ES2685824T3 (es) 2018-10-11
KR20140074868A (ko) 2014-06-18
KR102035187B1 (ko) 2019-11-08
EP2694116B1 (en) 2018-06-13
AU2017232156B2 (en) 2019-07-11
US20120258044A1 (en) 2012-10-11
PT2694116T (pt) 2018-10-12
AU2019246775A1 (en) 2019-10-31
AU2017232156A1 (en) 2017-10-12
MX357227B (es) 2018-07-02
CN104144708A (zh) 2014-11-12
EP2694116A4 (en) 2015-06-03
JP2018035167A (ja) 2018-03-08
WO2012139080A3 (en) 2014-05-01
BR112013025633A2 (pt) 2017-08-08
WO2012139080A2 (en) 2012-10-11
AU2012239888A1 (en) 2013-11-07
AU2012239888A2 (en) 2014-05-08
EP3366313A1 (en) 2018-08-29
JP2019151664A (ja) 2019-09-12
JP6533813B2 (ja) 2019-06-19
JP2014523854A (ja) 2014-09-18
KR101973063B1 (ko) 2019-04-30
AU2012239888B2 (en) 2017-06-22
MX2013011231A (es) 2015-03-05
DK2694116T3 (en) 2018-09-03
HK1203827A1 (en) 2015-11-06
CA2831480C (en) 2020-09-29
CA2831480A1 (en) 2012-10-11
PL2694116T3 (pl) 2018-12-31
EP2694116A2 (en) 2014-02-12

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