MX357227B - Nanoparticulas basadas en lipidos. - Google Patents
Nanoparticulas basadas en lipidos.Info
- Publication number
- MX357227B MX357227B MX2013011231A MX2013011231A MX357227B MX 357227 B MX357227 B MX 357227B MX 2013011231 A MX2013011231 A MX 2013011231A MX 2013011231 A MX2013011231 A MX 2013011231A MX 357227 B MX357227 B MX 357227B
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- lipid
- based nanoparticles
- amyloid
- liposomal
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
- A61K49/0461—Dispersions, colloids, emulsions or suspensions
- A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Abstract
Se proporcionan composiciones de nanopartículas basadas en lípidos. Las composiciones generalmente comprenden conjugados de ligando de unión a amiloide con polímero hidrofílico y lípido, y pueden ser composiciones liposómicas. Las composiciones, incluyendo las composiciones liposómicas, pueden ser útiles para la formación de Imágenes y para el tratamiento de los depósitos de la placa ß-amiloide característicos de la Enfermedad de Alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161472605P | 2011-04-06 | 2011-04-06 | |
PCT/US2012/032649 WO2012139080A2 (en) | 2011-04-06 | 2012-04-06 | Lipid-based nanoparticles |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013011231A MX2013011231A (es) | 2015-03-05 |
MX357227B true MX357227B (es) | 2018-07-02 |
Family
ID=46966277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013011231A MX357227B (es) | 2011-04-06 | 2012-04-06 | Nanoparticulas basadas en lipidos. |
Country Status (15)
Country | Link |
---|---|
US (1) | US9801957B2 (es) |
EP (2) | EP3366313A1 (es) |
JP (3) | JP6212032B2 (es) |
KR (2) | KR101973063B1 (es) |
CN (1) | CN104144708B (es) |
AU (3) | AU2012239888B9 (es) |
BR (1) | BR112013025633A2 (es) |
CA (1) | CA2831480C (es) |
DK (1) | DK2694116T3 (es) |
ES (1) | ES2685824T3 (es) |
HK (1) | HK1203827A1 (es) |
MX (1) | MX357227B (es) |
PL (1) | PL2694116T3 (es) |
PT (1) | PT2694116T (es) |
WO (1) | WO2012139080A2 (es) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012139080A2 (en) * | 2011-04-06 | 2012-10-11 | Board Of Regents Of The University Of Texas System | Lipid-based nanoparticles |
BR112014010879A2 (pt) | 2012-01-20 | 2017-06-13 | Annapragada Ananth | métodos e composições para caracterizar objetivamente imagens médicas |
US9512092B2 (en) | 2013-12-12 | 2016-12-06 | Albert Einstein College Of Medicine, Inc. | Retinoic acid receptor antagonists as chaperone-mediated autophagy modulators and uses thereof |
KR102409017B1 (ko) * | 2014-10-08 | 2022-06-16 | 텍사스 칠드런스 하스피탈 | 리포좀을 이용한 아밀로이드 플라크의 mri 영상화 |
GB201509934D0 (en) | 2015-06-08 | 2015-07-22 | King S College London | Nanoparticles |
JP7312552B2 (ja) * | 2016-05-16 | 2023-07-21 | ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム | ナノ粒子としてのtRNA送達用組成物およびその使用方法 |
WO2018100540A1 (en) * | 2016-11-30 | 2018-06-07 | Texas Children's Hospital | Hydrophilic fluorinated molecules for liposomal 19f mri probes with unique mr signatures |
JP2022523056A (ja) * | 2019-01-24 | 2022-04-21 | アルゼカ バイオサイエンシズ、エルエルシー | 誤って折りたたまれたタンパク質を画像化するための機能化リポソーム |
EP4096722A4 (en) * | 2020-01-29 | 2023-06-28 | Texas Children's Hospital | Targeted contrast agents for mri of amyloid deposition |
US11779664B2 (en) | 2020-02-12 | 2023-10-10 | Texas Children's Hospital | Targeted contrast agents for MRI of alpha-synuclein deposition |
CN115279424A (zh) * | 2020-02-12 | 2022-11-01 | 德克萨斯儿童医院 | 用于α-突触核蛋白沉积MRI的靶向对比剂 |
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US4331751A (en) * | 1980-11-17 | 1982-05-25 | Eastman Kodak Company | Electrically photosensitive materials and elements for photoelectrophoretic imaging processes |
US5204085A (en) | 1985-01-08 | 1993-04-20 | Mallinckrodt Medical, Inc. | Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents |
US5674468A (en) | 1992-03-06 | 1997-10-07 | Nycomed Imaging As | Contrast agents comprising gas-containing or gas-generating polymer microparticles or microballoons |
ZA952485B (en) | 1994-03-28 | 1995-12-15 | Nycomed Imaging As | Liposomes |
US6071532A (en) | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
AU2427601A (en) * | 1999-11-30 | 2001-06-12 | Arizona Board Of Regents On Behalf Of The University Of Arizona, The | Radiation sensitive liposomes |
WO2002028441A2 (en) * | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
US6821504B2 (en) * | 2001-05-23 | 2004-11-23 | New York University | Detection of alzheimer's amyloid by magnetic resonance imaging |
EP1480691A4 (en) | 2002-03-05 | 2007-11-28 | Univ State Cleveland | AGGLOMERATED PARTICLES FOR ADMINISTERING AEROSOL DRUGS |
EP1641742A4 (en) | 2003-05-01 | 2006-11-29 | Nst Neurosurvival Technologies | COMPOUNDS BINDING SELECTIVELY TO MEMBRANES OF APOPTOTIC CELLS |
US7208174B2 (en) * | 2003-12-18 | 2007-04-24 | Hoffmann-La Roche Inc. | Liposome compositions |
US20100031378A1 (en) | 2008-08-04 | 2010-02-04 | Edwards Joel A | Novel gene disruptions, compositions and methods relating thereto |
US8357351B2 (en) | 2004-04-21 | 2013-01-22 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
US7713517B2 (en) | 2004-04-21 | 2010-05-11 | Marval Biosciences, Inc. | Compositions and methods for enhancing contrast in imaging |
US7803351B2 (en) * | 2004-08-20 | 2010-09-28 | Washington University | Blood brain barrier permeation peptides |
ATE493152T1 (de) * | 2004-09-23 | 2011-01-15 | Guerbet Sa | Liposomale kontrastmittel für die cest-bildgebung |
WO2006126208A2 (en) * | 2005-05-26 | 2006-11-30 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions and methods using same for delivering agents into a target organ protected by a blood barrier |
WO2007048019A2 (en) * | 2005-10-20 | 2007-04-26 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
US20100062969A1 (en) | 2006-04-07 | 2010-03-11 | Hayat Onyuksel | Hydrophilic polymer-conjugated lipids for peptide and protein folding disorders |
US20090123047A1 (en) | 2007-03-21 | 2009-05-14 | Yfantis Spyros A | Method and system for characterizing prostate images |
EP1982733A1 (en) | 2007-04-17 | 2008-10-22 | Bayer Schering Pharma Aktiengesellschaft | Use of a contrast agent for magnetic resonance imaging of endoleaks |
AU2008278605A1 (en) | 2007-07-26 | 2009-01-29 | Nanoscan Imaging, Llc | Methods for imaging using improved nanoparticulate contrast agents |
CN104274840A (zh) | 2007-12-05 | 2015-01-14 | 马维尔生物科学公司 | 纳米级对比剂和使用方法 |
US20100286067A1 (en) | 2008-01-08 | 2010-11-11 | Biogenerix Ag | Glycoconjugation of polypeptides using oligosaccharyltransferases |
ITMI20081052A1 (it) * | 2008-06-10 | 2009-12-11 | Univ Milano Bicocca | Liposomi in grado di legare efficacemente il peptide beta-amiloide |
WO2009152445A1 (en) * | 2008-06-13 | 2009-12-17 | Marval Biosciences, Inc. | Imaging of atherosclerotic plaques using liposomal imaging agents |
US20110208064A1 (en) | 2008-07-31 | 2011-08-25 | Ran Chongzhao | Curcumin Derivatives for Amyloid-Beta Plaque Imaging |
AR074760A1 (es) | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
JP2012520898A (ja) * | 2009-03-19 | 2012-09-10 | マーヴァル バイオサイエンシーズ,インコーポレイテッド | 画像化におけるコントラスト強調のための組成物および方法 |
US9334304B2 (en) * | 2009-04-02 | 2016-05-10 | The Johns Hopkins University | Self-assembling peptides bearing organic electronic functionality and applications employing the same |
US20120263646A1 (en) | 2009-10-15 | 2012-10-18 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
CA2801182A1 (en) | 2010-06-16 | 2011-12-22 | Metabolex, Inc. | Gpr120 receptor agonists and uses thereof |
WO2012119117A1 (en) | 2011-03-02 | 2012-09-07 | Sensulin, Llc | Vesicle compositions |
WO2012139080A2 (en) | 2011-04-06 | 2012-10-11 | Board Of Regents Of The University Of Texas System | Lipid-based nanoparticles |
GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
BR112014010879A2 (pt) | 2012-01-20 | 2017-06-13 | Annapragada Ananth | métodos e composições para caracterizar objetivamente imagens médicas |
WO2013164763A2 (en) | 2012-04-30 | 2013-11-07 | Innovative Health Diagnostics | A biological complex specific for alzheimer's disease detection in vitro and use thereof |
BR112015022226A2 (pt) | 2013-03-14 | 2017-07-18 | Celtaxsys Inc | inibidores de leucotrieno a4 hidrolase |
KR102409017B1 (ko) | 2014-10-08 | 2022-06-16 | 텍사스 칠드런스 하스피탈 | 리포좀을 이용한 아밀로이드 플라크의 mri 영상화 |
-
2012
- 2012-04-06 WO PCT/US2012/032649 patent/WO2012139080A2/en active Application Filing
- 2012-04-06 KR KR1020137029510A patent/KR101973063B1/ko active IP Right Review Request
- 2012-04-06 DK DK12767275.6T patent/DK2694116T3/en active
- 2012-04-06 ES ES12767275.6T patent/ES2685824T3/es active Active
- 2012-04-06 BR BR112013025633A patent/BR112013025633A2/pt not_active Application Discontinuation
- 2012-04-06 PT PT12767275T patent/PT2694116T/pt unknown
- 2012-04-06 CN CN201280017548.6A patent/CN104144708B/zh not_active Expired - Fee Related
- 2012-04-06 US US13/441,816 patent/US9801957B2/en not_active Expired - Fee Related
- 2012-04-06 AU AU2012239888A patent/AU2012239888B9/en not_active Ceased
- 2012-04-06 PL PL12767275T patent/PL2694116T3/pl unknown
- 2012-04-06 EP EP18167725.3A patent/EP3366313A1/en not_active Withdrawn
- 2012-04-06 KR KR1020197007384A patent/KR102035187B1/ko active IP Right Grant
- 2012-04-06 MX MX2013011231A patent/MX357227B/es active IP Right Grant
- 2012-04-06 JP JP2014504057A patent/JP6212032B2/ja not_active Expired - Fee Related
- 2012-04-06 EP EP12767275.6A patent/EP2694116B1/en not_active Not-in-force
- 2012-04-06 CA CA2831480A patent/CA2831480C/en not_active Expired - Fee Related
-
2015
- 2015-05-08 HK HK15104390.1A patent/HK1203827A1/xx not_active IP Right Cessation
-
2017
- 2017-09-14 JP JP2017176383A patent/JP6533813B2/ja not_active Expired - Fee Related
- 2017-09-21 AU AU2017232156A patent/AU2017232156C1/en not_active Ceased
-
2019
- 2019-05-27 JP JP2019098174A patent/JP2019151664A/ja active Pending
- 2019-10-08 AU AU2019246775A patent/AU2019246775A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |