WO2012153253A3 - Aromatic compounds and metal complexes thereof - Google Patents

Aromatic compounds and metal complexes thereof Download PDF

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Publication number
WO2012153253A3
WO2012153253A3 PCT/IB2012/052256 IB2012052256W WO2012153253A3 WO 2012153253 A3 WO2012153253 A3 WO 2012153253A3 IB 2012052256 W IB2012052256 W IB 2012052256W WO 2012153253 A3 WO2012153253 A3 WO 2012153253A3
Authority
WO
WIPO (PCT)
Prior art keywords
metal complexes
aromatic compounds
methods
diagnosing
cancer
Prior art date
Application number
PCT/IB2012/052256
Other languages
French (fr)
Other versions
WO2012153253A2 (en
Inventor
Jan Gysbert Hermanus Du Preez
Mauritz WENTZEL
Steyn Knoetze
Original Assignee
Jan Gysbert Hermanus Du Preez
Wentzel Mauritz
Steyn Knoetze
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jan Gysbert Hermanus Du Preez, Wentzel Mauritz, Steyn Knoetze filed Critical Jan Gysbert Hermanus Du Preez
Publication of WO2012153253A2 publication Critical patent/WO2012153253A2/en
Publication of WO2012153253A3 publication Critical patent/WO2012153253A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic System compounds of the platinum group
    • C07F15/006—Palladium compounds
    • C07F15/0066—Palladium compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

Abstract

Provided are aromatic compounds and metal complexes thereof which may be useful treating various forms of proliferative diseases, such as cancer. In some instances, the metal complexes thereof are relatively stable, and may be suitable for oral administration. Also provided are methods of treatment, as well as methods of imaging or diagnosing a disease in a subject.
PCT/IB2012/052256 2011-05-06 2012-05-07 Aromatic compounds and metal complexes thereof WO2012153253A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161483593P 2011-05-06 2011-05-06
US61/483,593 2011-05-06

Publications (2)

Publication Number Publication Date
WO2012153253A2 WO2012153253A2 (en) 2012-11-15
WO2012153253A3 true WO2012153253A3 (en) 2013-01-17

Family

ID=47139745

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2012/052256 WO2012153253A2 (en) 2011-05-06 2012-05-07 Aromatic compounds and metal complexes thereof

Country Status (1)

Country Link
WO (1) WO2012153253A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103709196B (en) * 2014-01-13 2016-08-17 武汉大学 Coordination compound and application thereof containing PA base tetradentate ligands
AU2016206808A1 (en) 2015-01-14 2017-08-31 Bristol-Myers Squibb Company Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
CN104892494B (en) * 2015-06-01 2017-08-11 河南师范大学 A kind of preparation method of the ＇ bipyridyls of 4,4 ＇ dimethyl 2,2
CN106432070A (en) * 2016-09-20 2017-02-22 上海应用技术大学 Preparation method of dimethyl 6,6'-bis(bromomethyl)-[2,2'-bipyridine]-4,4'-dicarboxylate

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0283751A2 (en) * 1987-02-25 1988-09-28 AQUANAUTICS CORPORATION (a Californian corporation) Polyalkylamine complexes for ligand extraction and generation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0283751A2 (en) * 1987-02-25 1988-09-28 AQUANAUTICS CORPORATION (a Californian corporation) Polyalkylamine complexes for ligand extraction and generation

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EL-GBAYOURY ET AL.: "Convienient synthetic route to polypyridine esters by palladium-promoted carbalkoxylation", TETRAHEDRON LETTERS, vol. 39, no. 25, 1998, pages 4473 - 4476 *

Also Published As

Publication number Publication date
WO2012153253A2 (en) 2012-11-15

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