JP2017532378A5 - - Google Patents
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- JP2017532378A5 JP2017532378A5 JP2017538918A JP2017538918A JP2017532378A5 JP 2017532378 A5 JP2017532378 A5 JP 2017532378A5 JP 2017538918 A JP2017538918 A JP 2017538918A JP 2017538918 A JP2017538918 A JP 2017538918A JP 2017532378 A5 JP2017532378 A5 JP 2017532378A5
- Authority
- JP
- Japan
- Prior art keywords
- phospholipid
- polymer
- liposome composition
- aromatic
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462061514P | 2014-10-08 | 2014-10-08 | |
| US62/061,514 | 2014-10-08 | ||
| US201562111057P | 2015-02-02 | 2015-02-02 | |
| US62/111,057 | 2015-02-02 | ||
| PCT/US2015/054732 WO2016057812A1 (en) | 2014-10-08 | 2015-10-08 | Mri imaging of amyloid plaque using liposomes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017532378A JP2017532378A (ja) | 2017-11-02 |
| JP2017532378A5 true JP2017532378A5 (enExample) | 2018-11-22 |
| JP6505235B2 JP6505235B2 (ja) | 2019-04-24 |
Family
ID=55653789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017538918A Active JP6505235B2 (ja) | 2014-10-08 | 2015-10-08 | リポソームを用いるアミロイド斑のmriイメージング |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9744251B2 (enExample) |
| EP (3) | EP3204051B1 (enExample) |
| JP (1) | JP6505235B2 (enExample) |
| KR (1) | KR102409017B1 (enExample) |
| CN (1) | CN107106708B (enExample) |
| AU (2) | AU2015330824A1 (enExample) |
| CA (1) | CA2963941C (enExample) |
| ES (2) | ES2743704T3 (enExample) |
| MX (1) | MX371295B (enExample) |
| WO (1) | WO2016057812A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3366313A1 (en) | 2011-04-06 | 2018-08-29 | Board Of Regents Of the University Of Texas System | Lipid-based nanoparticles |
| JP6130401B2 (ja) | 2012-01-20 | 2017-05-17 | アンナプラガダ,アナンス | 医学画像を客観的に特徴付けるための方法および組成物 |
| CN107106708B (zh) | 2014-10-08 | 2021-06-18 | 德克萨斯州儿童医院 | 使用脂质体进行的淀粉样蛋白斑mri成像 |
| MX386900B (es) | 2016-07-22 | 2025-03-19 | Ac Immune S A Star | Compuestos para formacion de imagenes de agregados de proteinas tau. |
| WO2018015546A1 (en) | 2016-07-22 | 2018-01-25 | Ac Immune S.A. | Compounds for imaging tau protein aggregates |
| US11052162B2 (en) | 2016-09-16 | 2021-07-06 | Texas Children's Hospital | Liposomal gadolinium (GD) contrast agent “NMRX” for T1-MRI |
| CN110022859B (zh) * | 2016-11-30 | 2022-10-28 | 德克萨斯州儿童医院 | 具有独特的mr特征用于脂质体19f mri探针的亲水性氟化分子 |
| EP3743423A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Gamma-carboline compounds for the detection of tau aggregates |
| EP3743426A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Azacarboline compounds for the detection of tau aggregates |
| US20210008204A1 (en) * | 2018-03-29 | 2021-01-14 | Microvascular Therapeutics LLC | Compositions and methods of detecting and treating alzheimer's disease |
| KR20210020072A (ko) | 2018-06-08 | 2021-02-23 | 에이씨 이뮨 에스.에이. | 진단을 위한 신규한 화합물 |
| EP3914230A4 (en) * | 2019-01-24 | 2023-06-07 | Alzeca Biosciences, Llc | <SMALLCAPS/>? ? ?FUNCTIONALIZED LIPOSOMES FOR IMAGE MISFOLDED PROTEINS |
| WO2021007232A1 (en) * | 2019-07-08 | 2021-01-14 | Alzeca Biosciences, LLC | Targeting ligands for tau pathology |
| US11614451B2 (en) | 2019-07-08 | 2023-03-28 | Alzeca Biosciences, LLC | Targeting ligands for tau pathology |
| CN115916263B (zh) * | 2020-01-29 | 2025-10-03 | 德克萨斯儿童医院 | 用于淀粉样蛋白沉积mri的靶向对比剂 |
| US11779664B2 (en) | 2020-02-12 | 2023-10-10 | Texas Children's Hospital | Targeted contrast agents for MRI of alpha-synuclein deposition |
| CN115279424A (zh) * | 2020-02-12 | 2022-11-01 | 德克萨斯儿童医院 | 用于α-突触核蛋白沉积MRI的靶向对比剂 |
| CN115970009A (zh) * | 2023-02-08 | 2023-04-18 | 丽水市中心医院 | Vhpk多肽修饰的荧光纳米脂质体给药系统、其制备方法及应用 |
| CN116869938A (zh) * | 2023-07-26 | 2023-10-13 | 安徽医科大学 | 一种1,2,4-噁二唑-吡啶脂质体及其制备方法和应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204085A (en) | 1985-01-08 | 1993-04-20 | Mallinckrodt Medical, Inc. | Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents |
| ZA952485B (en) | 1994-03-28 | 1995-12-15 | Nycomed Imaging As | Liposomes |
| US6071532A (en) * | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| DE60017787T2 (de) | 1999-11-30 | 2006-01-05 | ARIZONA BOARD OF REGENTS, on behalf of THE UNIVERSITY OF ARIZONA, Tucson | Strahlung-sensitive liposomen |
| AU2002211517A1 (en) | 2000-10-04 | 2002-04-15 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| WO2002094191A2 (en) | 2001-05-23 | 2002-11-28 | New York University | Detection of alzheimer's amyloid by magnetic resonance imaging |
| US7138136B2 (en) | 2002-03-05 | 2006-11-21 | Cleveland State University | Agglomerated particles for aerosol drug delivery |
| US7605182B2 (en) | 2003-05-01 | 2009-10-20 | Aposense Ltd. | Compounds that selectively bind to membranes of apoptotic cells |
| US7208174B2 (en) | 2003-12-18 | 2007-04-24 | Hoffmann-La Roche Inc. | Liposome compositions |
| US20100031378A1 (en) | 2008-08-04 | 2010-02-04 | Edwards Joel A | Novel gene disruptions, compositions and methods relating thereto |
| US7713517B2 (en) | 2004-04-21 | 2010-05-11 | Marval Biosciences, Inc. | Compositions and methods for enhancing contrast in imaging |
| US8357351B2 (en) | 2004-04-21 | 2013-01-22 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
| ATE493152T1 (de) | 2004-09-23 | 2011-01-15 | Guerbet Sa | Liposomale kontrastmittel für die cest-bildgebung |
| WO2007119108A2 (en) | 2005-10-13 | 2007-10-25 | Waratah Pharmaceuticals Inc. | Inositol derivatives and their uses in the treatment of diseases characterized by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence |
| US20070160658A1 (en) | 2005-10-20 | 2007-07-12 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
| US20090123047A1 (en) | 2007-03-21 | 2009-05-14 | Yfantis Spyros A | Method and system for characterizing prostate images |
| EP1982733A1 (en) | 2007-04-17 | 2008-10-22 | Bayer Schering Pharma Aktiengesellschaft | Use of a contrast agent for magnetic resonance imaging of endoleaks |
| US7858803B2 (en) | 2007-04-27 | 2010-12-28 | The General Hospital Corporation | Imaging tracers for early detection and treatment of amyloid plaques caused by Alzheimer's disease and related disorders |
| US20110311457A1 (en) | 2007-07-26 | 2011-12-22 | Nanoscan Imaging, Llc | Methods for imaging vascular inflammation using improved nanoparticle contrast agents |
| JP2011506325A (ja) | 2007-12-05 | 2011-03-03 | マーバル バイオサイエンシーズ インコーポレイテッド | ナノスケールのコントラスト剤及びその使用方法 |
| JP5647899B2 (ja) | 2008-01-08 | 2015-01-07 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化 |
| ITMI20081052A1 (it) | 2008-06-10 | 2009-12-11 | Univ Milano Bicocca | Liposomi in grado di legare efficacemente il peptide beta-amiloide |
| WO2009152445A1 (en) | 2008-06-13 | 2009-12-17 | Marval Biosciences, Inc. | Imaging of atherosclerotic plaques using liposomal imaging agents |
| WO2010017094A2 (en) | 2008-07-31 | 2010-02-11 | The General Hospital Corporation | CURCUMIN DERIVATIVES FOR AMYLOID-β PLAQUE IMAGING |
| AR074760A1 (es) * | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| US20120003159A1 (en) | 2009-03-19 | 2012-01-05 | Board Of Regents Of The University Of Texas System | Compositions and methods for enhancing contrast in imaging |
| EP2501696B1 (en) | 2009-10-15 | 2016-12-28 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| EP2582674B1 (en) | 2010-06-16 | 2014-10-01 | Cymabay Therapeutics, Inc. | Gpr120 receptor agonists and uses thereof |
| MX345504B (es) | 2011-03-02 | 2017-02-02 | Sensulin Llc | Composiciones de vesicula. |
| EP3366313A1 (en) | 2011-04-06 | 2018-08-29 | Board Of Regents Of the University Of Texas System | Lipid-based nanoparticles |
| GB201112056D0 (en) * | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
| JP6130401B2 (ja) | 2012-01-20 | 2017-05-17 | アンナプラガダ,アナンス | 医学画像を客観的に特徴付けるための方法および組成物 |
| WO2013164763A2 (en) * | 2012-04-30 | 2013-11-07 | Innovative Health Diagnostics | A biological complex specific for alzheimer's disease detection in vitro and use thereof |
| AU2014240042C1 (en) * | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| CN107106708B (zh) | 2014-10-08 | 2021-06-18 | 德克萨斯州儿童医院 | 使用脂质体进行的淀粉样蛋白斑mri成像 |
-
2015
- 2015-10-08 CN CN201580066712.6A patent/CN107106708B/zh active Active
- 2015-10-08 ES ES15849750T patent/ES2743704T3/es active Active
- 2015-10-08 EP EP15849750.3A patent/EP3204051B1/en active Active
- 2015-10-08 KR KR1020177012354A patent/KR102409017B1/ko active Active
- 2015-10-08 ES ES22152987T patent/ES3032054T3/es active Active
- 2015-10-08 EP EP22152987.8A patent/EP4035688B1/en active Active
- 2015-10-08 JP JP2017538918A patent/JP6505235B2/ja active Active
- 2015-10-08 US US14/878,745 patent/US9744251B2/en active Active
- 2015-10-08 MX MX2017004695A patent/MX371295B/es active IP Right Grant
- 2015-10-08 EP EP19172751.0A patent/EP3542828A1/en not_active Withdrawn
- 2015-10-08 WO PCT/US2015/054732 patent/WO2016057812A1/en not_active Ceased
- 2015-10-08 AU AU2015330824A patent/AU2015330824A1/en not_active Abandoned
- 2015-10-08 CA CA2963941A patent/CA2963941C/en active Active
-
2016
- 2016-12-01 US US15/366,667 patent/US10537649B2/en active Active
-
2019
- 2019-11-08 US US16/677,751 patent/US20200069820A1/en not_active Abandoned
-
2020
- 2020-02-14 US US16/791,068 patent/US11141495B2/en active Active
-
2021
- 2021-05-25 AU AU2021203388A patent/AU2021203388B2/en active Active
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