MX371295B - Formación de imágenes por irm de placas amiloides usando liposomas. - Google Patents
Formación de imágenes por irm de placas amiloides usando liposomas.Info
- Publication number
- MX371295B MX371295B MX2017004695A MX2017004695A MX371295B MX 371295 B MX371295 B MX 371295B MX 2017004695 A MX2017004695 A MX 2017004695A MX 2017004695 A MX2017004695 A MX 2017004695A MX 371295 B MX371295 B MX 371295B
- Authority
- MX
- Mexico
- Prior art keywords
- liposomes
- mri imaging
- amyloid plaque
- imaging
- aromatic
- Prior art date
Links
- 238000003384 imaging method Methods 0.000 title abstract 3
- 239000002502 liposome Substances 0.000 title abstract 2
- 208000037259 Amyloid Plaque Diseases 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 2
- 150000001491 aromatic compounds Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 102000013455 Amyloid beta-Peptides Human genes 0.000 abstract 1
- 108010090849 Amyloid beta-Peptides Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
- A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
- A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
- A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
- A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Polyethers (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462061514P | 2014-10-08 | 2014-10-08 | |
| US201562111057P | 2015-02-02 | 2015-02-02 | |
| PCT/US2015/054732 WO2016057812A1 (en) | 2014-10-08 | 2015-10-08 | Mri imaging of amyloid plaque using liposomes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2017004695A MX2017004695A (es) | 2018-01-24 |
| MX371295B true MX371295B (es) | 2020-01-24 |
Family
ID=55653789
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2017004695A MX371295B (es) | 2014-10-08 | 2015-10-08 | Formación de imágenes por irm de placas amiloides usando liposomas. |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US9744251B2 (enExample) |
| EP (3) | EP3542828A1 (enExample) |
| JP (1) | JP6505235B2 (enExample) |
| KR (1) | KR102409017B1 (enExample) |
| CN (1) | CN107106708B (enExample) |
| AU (2) | AU2015330824A1 (enExample) |
| CA (1) | CA2963941C (enExample) |
| ES (2) | ES3032054T3 (enExample) |
| MX (1) | MX371295B (enExample) |
| WO (1) | WO2016057812A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9801957B2 (en) | 2011-04-06 | 2017-10-31 | Ananth Annapragada | Lipid-based nanoparticles |
| EP2756459B1 (en) | 2012-01-20 | 2020-12-09 | Ananth Annapragada | Methods and compositions for objectively characterizing medical images |
| EP3542828A1 (en) | 2014-10-08 | 2019-09-25 | Texas Children's Hospital | Mri imaging of amyloid plaque using liposomes |
| EP3487545A1 (en) | 2016-07-22 | 2019-05-29 | AC Immune S.A. | Compounds for imaging tau protein aggregates |
| WO2018015549A1 (en) | 2016-07-22 | 2018-01-25 | Ac Immune S.A. | Compounds for imaging tau protein aggregates |
| US11052162B2 (en) | 2016-09-16 | 2021-07-06 | Texas Children's Hospital | Liposomal gadolinium (GD) contrast agent “NMRX” for T1-MRI |
| EP3548002B1 (en) | 2016-11-30 | 2025-04-30 | Texas Children's Hospital | Hydrophilic fluorinated molecules for liposomal 19f mri probes with unique mr signatures |
| EP3743426A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Azacarboline compounds for the detection of tau aggregates |
| WO2019145291A1 (en) | 2018-01-24 | 2019-08-01 | Ac Immune Sa | Gamma-carboline compounds for the detection of tau aggregates |
| CN116173238A (zh) * | 2018-03-29 | 2023-05-30 | 微脉管治疗有限公司 | 用于检测和治疗阿尔茨海默病的组合物及方法 |
| WO2019234243A1 (en) | 2018-06-08 | 2019-12-12 | Ac Immune Sa | Novel compounds for diagnosis |
| JP7545393B2 (ja) * | 2019-01-24 | 2024-09-04 | アルゼカ バイオサイエンシズ、エルエルシー | 誤って折りたたまれたタンパク質を画像化するための機能化リポソーム |
| CN114341364B (zh) * | 2019-07-08 | 2025-07-18 | 阿尔兹卡生物科学公司 | Tau病理靶向配体 |
| US11614451B2 (en) | 2019-07-08 | 2023-03-28 | Alzeca Biosciences, LLC | Targeting ligands for tau pathology |
| KR102546470B1 (ko) * | 2020-01-29 | 2023-06-21 | 텍사스 칠드런스 하스피탈 | 아밀로이드 침착의 mri용 표적 조영제 |
| WO2021163585A1 (en) | 2020-02-12 | 2021-08-19 | Texas Children's Hospital | Targeted contrast agents for mri of alpha-synuclein deposition |
| US11779664B2 (en) | 2020-02-12 | 2023-10-10 | Texas Children's Hospital | Targeted contrast agents for MRI of alpha-synuclein deposition |
| CN115970009A (zh) * | 2023-02-08 | 2023-04-18 | 丽水市中心医院 | Vhpk多肽修饰的荧光纳米脂质体给药系统、其制备方法及应用 |
| CN116869938A (zh) * | 2023-07-26 | 2023-10-13 | 安徽医科大学 | 一种1,2,4-噁二唑-吡啶脂质体及其制备方法和应用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204085A (en) | 1985-01-08 | 1993-04-20 | Mallinckrodt Medical, Inc. | Method for enhancing the safety of metal-ligand chelates as X-ray contrast agents |
| CN1148812A (zh) | 1994-03-28 | 1997-04-30 | 尼科梅德成像有限公司 | “脂质体” |
| US6071532A (en) | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| JP4829454B2 (ja) | 1999-11-30 | 2011-12-07 | ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ | 放射線感受性リポソーム |
| WO2002028441A2 (en) | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| WO2002094191A2 (en) | 2001-05-23 | 2002-11-28 | New York University | Detection of alzheimer's amyloid by magnetic resonance imaging |
| AU2003217950A1 (en) | 2002-03-05 | 2003-09-22 | Cleveland State University | Agglomerated particles for aerosol drug delivery |
| EP1641742A4 (en) | 2003-05-01 | 2006-11-29 | Nst Neurosurvival Technologies | COMPOUNDS BINDING SELECTIVELY TO MEMBRANES OF APOPTOTIC CELLS |
| US7208174B2 (en) | 2003-12-18 | 2007-04-24 | Hoffmann-La Roche Inc. | Liposome compositions |
| US20100031378A1 (en) | 2008-08-04 | 2010-02-04 | Edwards Joel A | Novel gene disruptions, compositions and methods relating thereto |
| US8357351B2 (en) | 2004-04-21 | 2013-01-22 | Ananth Annapragada | Nano-scale contrast agents and methods of use |
| US7713517B2 (en) | 2004-04-21 | 2010-05-11 | Marval Biosciences, Inc. | Compositions and methods for enhancing contrast in imaging |
| WO2006032705A2 (en) | 2004-09-23 | 2006-03-30 | Guerbet | Contrast agents encapsulating systems for cest imaging |
| WO2007041855A1 (en) | 2005-10-13 | 2007-04-19 | Waratah Pharmaceuticals, Inc. | Scyllo-inositol derivatives and their use in the treatment of diseases characterised by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence |
| WO2007048019A2 (en) | 2005-10-20 | 2007-04-26 | The Penn State Research Foundation | Delivery system for diagnostic and therapeutic agents |
| US20090123047A1 (en) | 2007-03-21 | 2009-05-14 | Yfantis Spyros A | Method and system for characterizing prostate images |
| EP1982733A1 (en) | 2007-04-17 | 2008-10-22 | Bayer Schering Pharma Aktiengesellschaft | Use of a contrast agent for magnetic resonance imaging of endoleaks |
| WO2008134618A2 (en) | 2007-04-27 | 2008-11-06 | The General Hospital Corporation | Novel imaging tracers for early detection and treatment of amyloid plaques caused by alzheimer's disease and related disorders |
| CA2695204A1 (en) | 2007-07-26 | 2009-01-29 | Nanoscan Imaging, Llc | Methods for imaging using improved nanoparticulate contrast agents |
| CA2708028A1 (en) | 2007-12-05 | 2009-06-11 | Marval Biosciences, Inc. | Nano-scale contrast agents and methods of use |
| CN102037004A (zh) * | 2008-01-08 | 2011-04-27 | 生物种属学股份公司 | 使用寡糖基转移酶的多肽的糖缀合 |
| ITMI20081052A1 (it) | 2008-06-10 | 2009-12-11 | Univ Milano Bicocca | Liposomi in grado di legare efficacemente il peptide beta-amiloide |
| WO2009152445A1 (en) | 2008-06-13 | 2009-12-17 | Marval Biosciences, Inc. | Imaging of atherosclerotic plaques using liposomal imaging agents |
| WO2010017094A2 (en) | 2008-07-31 | 2010-02-11 | The General Hospital Corporation | CURCUMIN DERIVATIVES FOR AMYLOID-β PLAQUE IMAGING |
| AR074760A1 (es) * | 2008-12-18 | 2011-02-09 | Metabolex Inc | Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. |
| JP2012520898A (ja) | 2009-03-19 | 2012-09-10 | マーヴァル バイオサイエンシーズ，インコーポレイテッド | 画像化におけるコントラスト強調のための組成物および方法 |
| US20120263646A1 (en) | 2009-10-15 | 2012-10-18 | Guerbet | Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases |
| ES2526124T3 (es) * | 2010-06-16 | 2015-01-07 | Cymabay Therapeutics, Inc. | Agonistas del receptor GPR120 y sus usos |
| AU2012223210B2 (en) | 2011-03-02 | 2016-12-22 | Board Of Regents Of The University Of Texas System | Vesicle compositions |
| US9801957B2 (en) * | 2011-04-06 | 2017-10-31 | Ananth Annapragada | Lipid-based nanoparticles |
| GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
| EP2756459B1 (en) | 2012-01-20 | 2020-12-09 | Ananth Annapragada | Methods and compositions for objectively characterizing medical images |
| WO2013164763A2 (en) | 2012-04-30 | 2013-11-07 | Innovative Health Diagnostics | A biological complex specific for alzheimer's disease detection in vitro and use thereof |
| AU2014240042C1 (en) * | 2013-03-14 | 2019-09-05 | Celltaxis, Llc | Inhibitors of leukotriene A4 hydrolase |
| EP3542828A1 (en) | 2014-10-08 | 2019-09-25 | Texas Children's Hospital | Mri imaging of amyloid plaque using liposomes |
-
2015
- 2015-10-08 EP EP19172751.0A patent/EP3542828A1/en not_active Withdrawn
- 2015-10-08 CA CA2963941A patent/CA2963941C/en active Active
- 2015-10-08 ES ES22152987T patent/ES3032054T3/es active Active
- 2015-10-08 AU AU2015330824A patent/AU2015330824A1/en not_active Abandoned
- 2015-10-08 ES ES15849750T patent/ES2743704T3/es active Active
- 2015-10-08 KR KR1020177012354A patent/KR102409017B1/ko active Active
- 2015-10-08 WO PCT/US2015/054732 patent/WO2016057812A1/en not_active Ceased
- 2015-10-08 US US14/878,745 patent/US9744251B2/en active Active
- 2015-10-08 JP JP2017538918A patent/JP6505235B2/ja active Active
- 2015-10-08 EP EP15849750.3A patent/EP3204051B1/en active Active
- 2015-10-08 CN CN201580066712.6A patent/CN107106708B/zh active Active
- 2015-10-08 EP EP22152987.8A patent/EP4035688B1/en active Active
- 2015-10-08 MX MX2017004695A patent/MX371295B/es active IP Right Grant
-
2016
- 2016-12-01 US US15/366,667 patent/US10537649B2/en active Active
-
2019
- 2019-11-08 US US16/677,751 patent/US20200069820A1/en not_active Abandoned
-
2020
- 2020-02-14 US US16/791,068 patent/US11141495B2/en active Active
-
2021
- 2021-05-25 AU AU2021203388A patent/AU2021203388B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3204051B1 (en) | 2019-05-29 |
| ES3032054T3 (en) | 2025-07-15 |
| CA2963941A1 (en) | 2016-04-14 |
| US20170080111A1 (en) | 2017-03-23 |
| US10537649B2 (en) | 2020-01-21 |
| JP2017532378A (ja) | 2017-11-02 |
| US20200179540A1 (en) | 2020-06-11 |
| EP4035688C0 (en) | 2025-03-26 |
| BR112017007238A2 (pt) | 2018-01-16 |
| AU2021203388B2 (en) | 2024-05-30 |
| KR20170103748A (ko) | 2017-09-13 |
| ES2743704T3 (es) | 2020-02-20 |
| HK1243335A1 (zh) | 2018-07-13 |
| EP3204051A4 (en) | 2018-06-27 |
| EP3204051A1 (en) | 2017-08-16 |
| AU2015330824A1 (en) | 2017-05-25 |
| EP4035688A1 (en) | 2022-08-03 |
| MX2017004695A (es) | 2018-01-24 |
| CN107106708B (zh) | 2021-06-18 |
| CA2963941C (en) | 2023-08-01 |
| AU2021203388A1 (en) | 2021-06-24 |
| EP4035688B1 (en) | 2025-03-26 |
| KR102409017B1 (ko) | 2022-06-16 |
| US20160101197A1 (en) | 2016-04-14 |
| US20200069820A1 (en) | 2020-03-05 |
| CN107106708A (zh) | 2017-08-29 |
| US9744251B2 (en) | 2017-08-29 |
| US11141495B2 (en) | 2021-10-12 |
| EP3542828A1 (en) | 2019-09-25 |
| JP6505235B2 (ja) | 2019-04-24 |
| WO2016057812A1 (en) | 2016-04-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |