ES3032054T3 - Mri imaging of amyloid plaque using liposomes - Google Patents

Mri imaging of amyloid plaque using liposomes

Info

Publication number
ES3032054T3
ES3032054T3 ES22152987T ES22152987T ES3032054T3 ES 3032054 T3 ES3032054 T3 ES 3032054T3 ES 22152987 T ES22152987 T ES 22152987T ES 22152987 T ES22152987 T ES 22152987T ES 3032054 T3 ES3032054 T3 ES 3032054T3
Authority
ES
Spain
Prior art keywords
aromatic
phospholipid
liposomal composition
polymer
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES22152987T
Other languages
English (en)
Spanish (es)
Inventor
Ananth Annapragada
Eric A Tanifum
Mayank Srivastava
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Texas Children's Hospital
Original Assignee
Texas Children's Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Children's Hospital filed Critical Texas Children's Hospital
Application granted granted Critical
Publication of ES3032054T3 publication Critical patent/ES3032054T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES22152987T 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes Active ES3032054T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462061514P 2014-10-08 2014-10-08
US201562111057P 2015-02-02 2015-02-02

Publications (1)

Publication Number Publication Date
ES3032054T3 true ES3032054T3 (en) 2025-07-15

Family

ID=55653789

Family Applications (2)

Application Number Title Priority Date Filing Date
ES22152987T Active ES3032054T3 (en) 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes
ES15849750T Active ES2743704T3 (es) 2014-10-08 2015-10-08 Obtención de imágenes de IRM de la placa amiloide usando liposomas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES15849750T Active ES2743704T3 (es) 2014-10-08 2015-10-08 Obtención de imágenes de IRM de la placa amiloide usando liposomas

Country Status (10)

Country Link
US (4) US9744251B2 (enExample)
EP (3) EP3542828A1 (enExample)
JP (1) JP6505235B2 (enExample)
KR (1) KR102409017B1 (enExample)
CN (1) CN107106708B (enExample)
AU (2) AU2015330824A1 (enExample)
CA (1) CA2963941C (enExample)
ES (2) ES3032054T3 (enExample)
MX (1) MX371295B (enExample)
WO (1) WO2016057812A1 (enExample)

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EP3542828A1 (en) 2014-10-08 2019-09-25 Texas Children's Hospital Mri imaging of amyloid plaque using liposomes
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WO2018015549A1 (en) 2016-07-22 2018-01-25 Ac Immune S.A. Compounds for imaging tau protein aggregates
US11052162B2 (en) 2016-09-16 2021-07-06 Texas Children's Hospital Liposomal gadolinium (GD) contrast agent “NMRX” for T1-MRI
EP3548002B1 (en) 2016-11-30 2025-04-30 Texas Children's Hospital Hydrophilic fluorinated molecules for liposomal 19f mri probes with unique mr signatures
EP3743426A1 (en) 2018-01-24 2020-12-02 AC Immune SA Azacarboline compounds for the detection of tau aggregates
WO2019145291A1 (en) 2018-01-24 2019-08-01 Ac Immune Sa Gamma-carboline compounds for the detection of tau aggregates
CN116173238A (zh) * 2018-03-29 2023-05-30 微脉管治疗有限公司 用于检测和治疗阿尔茨海默病的组合物及方法
WO2019234243A1 (en) 2018-06-08 2019-12-12 Ac Immune Sa Novel compounds for diagnosis
JP7545393B2 (ja) * 2019-01-24 2024-09-04 アルゼカ バイオサイエンシズ、エルエルシー 誤って折りたたまれたタンパク質を画像化するための機能化リポソーム
CN114341364B (zh) * 2019-07-08 2025-07-18 阿尔兹卡生物科学公司 Tau病理靶向配体
US11614451B2 (en) 2019-07-08 2023-03-28 Alzeca Biosciences, LLC Targeting ligands for tau pathology
KR102546470B1 (ko) * 2020-01-29 2023-06-21 텍사스 칠드런스 하스피탈 아밀로이드 침착의 mri용 표적 조영제
WO2021163585A1 (en) 2020-02-12 2021-08-19 Texas Children's Hospital Targeted contrast agents for mri of alpha-synuclein deposition
US11779664B2 (en) 2020-02-12 2023-10-10 Texas Children's Hospital Targeted contrast agents for MRI of alpha-synuclein deposition
CN115970009A (zh) * 2023-02-08 2023-04-18 丽水市中心医院 Vhpk多肽修饰的荧光纳米脂质体给药系统、其制备方法及应用
CN116869938A (zh) * 2023-07-26 2023-10-13 安徽医科大学 一种1,2,4-噁二唑-吡啶脂质体及其制备方法和应用

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Also Published As

Publication number Publication date
EP3204051B1 (en) 2019-05-29
CA2963941A1 (en) 2016-04-14
US20170080111A1 (en) 2017-03-23
US10537649B2 (en) 2020-01-21
JP2017532378A (ja) 2017-11-02
US20200179540A1 (en) 2020-06-11
EP4035688C0 (en) 2025-03-26
BR112017007238A2 (pt) 2018-01-16
AU2021203388B2 (en) 2024-05-30
KR20170103748A (ko) 2017-09-13
ES2743704T3 (es) 2020-02-20
HK1243335A1 (zh) 2018-07-13
EP3204051A4 (en) 2018-06-27
EP3204051A1 (en) 2017-08-16
AU2015330824A1 (en) 2017-05-25
EP4035688A1 (en) 2022-08-03
MX2017004695A (es) 2018-01-24
CN107106708B (zh) 2021-06-18
CA2963941C (en) 2023-08-01
AU2021203388A1 (en) 2021-06-24
EP4035688B1 (en) 2025-03-26
MX371295B (es) 2020-01-24
KR102409017B1 (ko) 2022-06-16
US20160101197A1 (en) 2016-04-14
US20200069820A1 (en) 2020-03-05
CN107106708A (zh) 2017-08-29
US9744251B2 (en) 2017-08-29
US11141495B2 (en) 2021-10-12
EP3542828A1 (en) 2019-09-25
JP6505235B2 (ja) 2019-04-24
WO2016057812A1 (en) 2016-04-14

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