CA2963941C - Mri imaging of amyloid plaque using liposomes - Google Patents

Mri imaging of amyloid plaque using liposomes Download PDF

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Publication number
CA2963941C
CA2963941C CA2963941A CA2963941A CA2963941C CA 2963941 C CA2963941 C CA 2963941C CA 2963941 A CA2963941 A CA 2963941A CA 2963941 A CA2963941 A CA 2963941A CA 2963941 C CA2963941 C CA 2963941C
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Prior art keywords
alkyl
liposomal composition
phospholipid
substituted
aromatic
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CA2963941A
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English (en)
French (fr)
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CA2963941A1 (en
Inventor
Eric A. Tanifum
Mayank Srivastava
Ananth Annapragada
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Texas Childrens Hospital
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Texas Childrens Hospital
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Publication of CA2963941A1 publication Critical patent/CA2963941A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A61K49/0034—Indocyanine green, i.e. ICG, cardiogreen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0063—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres
    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0076—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion
    • A61K49/0084—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form dispersion, suspension, e.g. particles in a liquid, colloid, emulsion liposome, i.e. bilayered vesicular structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Polyethers (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2963941A 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes Active CA2963941C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462061514P 2014-10-08 2014-10-08
US62/061,514 2014-10-08
US201562111057P 2015-02-02 2015-02-02
US62/111,057 2015-02-02
PCT/US2015/054732 WO2016057812A1 (en) 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes

Publications (2)

Publication Number Publication Date
CA2963941A1 CA2963941A1 (en) 2016-04-14
CA2963941C true CA2963941C (en) 2023-08-01

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CA2963941A Active CA2963941C (en) 2014-10-08 2015-10-08 Mri imaging of amyloid plaque using liposomes

Country Status (10)

Country Link
US (4) US9744251B2 (enExample)
EP (3) EP3204051B1 (enExample)
JP (1) JP6505235B2 (enExample)
KR (1) KR102409017B1 (enExample)
CN (1) CN107106708B (enExample)
AU (2) AU2015330824A1 (enExample)
CA (1) CA2963941C (enExample)
ES (2) ES3032054T3 (enExample)
MX (1) MX371295B (enExample)
WO (1) WO2016057812A1 (enExample)

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EP3743426A1 (en) 2018-01-24 2020-12-02 AC Immune SA Azacarboline compounds for the detection of tau aggregates
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US11116854B2 (en) * 2020-01-29 2021-09-14 Texas Children's Hospital Targeted contrast agents for MRI of amyloid deposition
CN115279424A (zh) * 2020-02-12 2022-11-01 德克萨斯儿童医院 用于α-突触核蛋白沉积MRI的靶向对比剂
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Also Published As

Publication number Publication date
JP6505235B2 (ja) 2019-04-24
US20170080111A1 (en) 2017-03-23
WO2016057812A1 (en) 2016-04-14
EP4035688B1 (en) 2025-03-26
AU2021203388A1 (en) 2021-06-24
US20200179540A1 (en) 2020-06-11
CN107106708B (zh) 2021-06-18
MX2017004695A (es) 2018-01-24
ES2743704T3 (es) 2020-02-20
CA2963941A1 (en) 2016-04-14
US10537649B2 (en) 2020-01-21
KR102409017B1 (ko) 2022-06-16
AU2015330824A1 (en) 2017-05-25
US20160101197A1 (en) 2016-04-14
MX371295B (es) 2020-01-24
US11141495B2 (en) 2021-10-12
EP3204051B1 (en) 2019-05-29
AU2021203388B2 (en) 2024-05-30
US20200069820A1 (en) 2020-03-05
HK1243335A1 (zh) 2018-07-13
EP3204051A4 (en) 2018-06-27
JP2017532378A (ja) 2017-11-02
EP4035688C0 (en) 2025-03-26
EP3204051A1 (en) 2017-08-16
US9744251B2 (en) 2017-08-29
KR20170103748A (ko) 2017-09-13
BR112017007238A2 (pt) 2018-01-16
ES3032054T3 (en) 2025-07-15
EP3542828A1 (en) 2019-09-25
CN107106708A (zh) 2017-08-29
EP4035688A1 (en) 2022-08-03

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