JP2010501009A5 - - Google Patents

Info

Publication number

JP2010501009A5

JP2010501009A5 JP2009524805A JP2009524805A JP2010501009A5 JP 2010501009 A5 JP2010501009 A5 JP 2010501009A5 JP 2009524805 A JP2009524805 A JP 2009524805A JP 2009524805 A JP2009524805 A JP 2009524805A JP 2010501009 A5 JP2010501009 A5 JP 2010501009A5

Authority

JP

Japan

Prior art keywords

region

contrast agent

image

mammal

ppbm

Prior art date

2007-08-16

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 28
• 239000002872 contrast media Substances 0.000 claims 20
• 241000124008 Mammalia Species 0.000 claims 11
• 210000001165 lymph node Anatomy 0.000 claims 8
• 125000000217 alkyl group Chemical group 0.000 claims 7
• 210000004204 blood vessel Anatomy 0.000 claims 7
• 210000004324 lymphatic system Anatomy 0.000 claims 7
• 125000003118 aryl group Chemical group 0.000 claims 6
• 230000005298 paramagnetic effect Effects 0.000 claims 6
• 102000004506 Blood Proteins Human genes 0.000 claims 5
• 108010017384 Blood Proteins Proteins 0.000 claims 5
• 150000004696 coordination complex Chemical class 0.000 claims 5
• 238000002347 injection Methods 0.000 claims 5
• 239000007924 injection Substances 0.000 claims 5
• 150000004713 phosphodiesters Chemical group 0.000 claims 5
• 125000003545 alkoxy group Chemical group 0.000 claims 4
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
• 230000001926 lymphatic effect Effects 0.000 claims 4
• 150000003839 salts Chemical class 0.000 claims 4
• MXZROTBGJUUXID-UHFFFAOYSA-I [Gd+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)C(C([O-])=O)COCC1=CC=CC=C1 Chemical compound [Gd+3].[O-]C(=O)CN(CC([O-])=O)CCN(CC(=O)[O-])CCN(CC([O-])=O)C(C([O-])=O)COCC1=CC=CC=C1 MXZROTBGJUUXID-UHFFFAOYSA-I 0.000 claims 3
• 201000011510 cancer Diseases 0.000 claims 3
• 125000000753 cycloalkyl group Chemical group 0.000 claims 3
• SLYTULCOCGSBBJ-FCQHKQNSSA-I disodium;2-[[(2s)-2-[bis(carboxylatomethyl)amino]-3-(4-ethoxyphenyl)propyl]-[2-[bis(carboxylatomethyl)amino]ethyl]amino]acetate;gadolinium(3+) Chemical compound [Na+].[Na+].[Gd+3].CCOC1=CC=C(C[C@@H](CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O)N(CC([O-])=O)CC([O-])=O)C=C1 SLYTULCOCGSBBJ-FCQHKQNSSA-I 0.000 claims 3
• 238000011156 evaluation Methods 0.000 claims 3
• 238000003384 imaging method Methods 0.000 claims 3
• 208000037819 metastatic cancer Diseases 0.000 claims 3
• 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 3
• 201000006353 Filariasis Diseases 0.000 claims 2
• 241000244005 Wuchereria bancrofti Species 0.000 claims 2
• 238000001574 biopsy Methods 0.000 claims 2
• 208000006036 elephantiasis Diseases 0.000 claims 2
• 125000004404 heteroalkyl group Chemical group 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 238000001802 infusion Methods 0.000 claims 2
• HHLZCENAOIROSL-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OC(=O)CN1CCNCCN(CC(O)=O)CCN(CC(O)=O)CC1 HHLZCENAOIROSL-UHFFFAOYSA-N 0.000 claims 1
• JHALWMSZGCVVEM-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7-triazonan-1-yl]acetic acid Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CC1 JHALWMSZGCVVEM-UHFFFAOYSA-N 0.000 claims 1
• VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 1
• 102000008100 Human Serum Albumin Human genes 0.000 claims 1
• 108091006905 Human Serum Albumin Proteins 0.000 claims 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
• QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical group OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
• 208000030852 Parasitic disease Diseases 0.000 claims 1
• WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 1
• 125000002877 alkyl aryl group Chemical group 0.000 claims 1
• 125000003710 aryl alkyl group Chemical group 0.000 claims 1
• 210000000481 breast Anatomy 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 210000004013 groin Anatomy 0.000 claims 1
• 125000005843 halogen group Chemical group 0.000 claims 1
• 229910052739 hydrogen Inorganic materials 0.000 claims 1
• 239000001257 hydrogen Substances 0.000 claims 1
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
• 238000001361 intraarterial administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 229910021645 metal ion Inorganic materials 0.000 claims 1
• 230000001629 suppression Effects 0.000 claims 1