CN101528124A - 用于淋巴系统成像的方法 - Google Patents

用于淋巴系统成像的方法 Download PDF

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Publication number
CN101528124A
CN101528124A CNA200780038841XA CN200780038841A CN101528124A CN 101528124 A CN101528124 A CN 101528124A CN A200780038841X A CNA200780038841X A CN A200780038841XA CN 200780038841 A CN200780038841 A CN 200780038841A CN 101528124 A CN101528124 A CN 101528124A
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CN
China
Prior art keywords
lymph node
lymph
image
contrast agent
nodes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA200780038841XA
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English (en)
Chinese (zh)
Inventor
V·雅克
P·D.·卡拉万
B·米赛尔维茨
H-J·魏因曼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epix Pharmaceuticals Inc
Original Assignee
Bayer Schering Pharma AG
Epix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG, Epix Pharmaceuticals Inc filed Critical Bayer Schering Pharma AG
Publication of CN101528124A publication Critical patent/CN101528124A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415—Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/41—Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414—Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418—Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Endocrinology (AREA)
  • General Physics & Mathematics (AREA)
  • Signal Processing (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CNA200780038841XA 2006-08-17 2007-08-16 用于淋巴系统成像的方法 Pending CN101528124A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83848806P 2006-08-17 2006-08-17
US60/838,488 2006-08-17

Publications (1)

Publication Number Publication Date
CN101528124A true CN101528124A (zh) 2009-09-09

Family

ID=39083140

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200780038841XA Pending CN101528124A (zh) 2006-08-17 2007-08-16 用于淋巴系统成像的方法

Country Status (7)

Country Link
US (1) US20080044358A1 (enExample)
EP (1) EP2053968A4 (enExample)
JP (1) JP5563299B2 (enExample)
KR (1) KR101336505B1 (enExample)
CN (1) CN101528124A (enExample)
CA (1) CA2660717A1 (enExample)
WO (1) WO2008022263A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113905659A (zh) * 2019-02-04 2022-01-07 麻省理工学院 用于淋巴结和血管成像的系统和方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090024022A1 (en) * 2006-10-25 2009-01-22 Siemens Corporate Research, Inc. System and method for lymph node imaging using co-registration of ct and mr imagery
US10076264B2 (en) 2013-03-31 2018-09-18 Case Western Reserve University System and method for quantitative magnetic resonance (MR) analysis using T1 mapping
US9747789B2 (en) * 2013-03-31 2017-08-29 Case Western Reserve University Magnetic resonance imaging with switched-mode current-source amplifier having gallium nitride field effect transistors for parallel transmission in MRI
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
JOP20210114A1 (ar) 2018-11-23 2023-01-30 Bayer Ag تركيبة وسط تباين وعملية لتحضيرها
WO2023177683A1 (en) * 2022-03-14 2023-09-21 The Board Of Trustees Of The Leland Stanford Junior University Devices, systems, and methods for treating volume overload

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0289304A (ja) * 1988-09-27 1990-03-29 Kitamura Kiden Kk 巻鉄心用帯材の切抜方法
US5114703A (en) * 1989-05-30 1992-05-19 Alliance Pharmaceutical Corp. Percutaneous lymphography using particulate fluorocarbon emulsions
US5843399A (en) * 1990-04-06 1998-12-01 Schering Aktiengesellschaft DTPA monoamides for MRI
DE4011684A1 (de) * 1990-04-06 1991-10-10 Schering Ag Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
EP0654973A4 (en) * 1992-07-21 1995-08-09 Gen Hospital Corp ARRANGEMENT FOR DELIVERING MEDICINES TO THE LYMPHIC TISSUE.
GB9216082D0 (en) * 1992-07-28 1992-09-09 Univ Nottingham Lymphatic delivery composition
TW319763B (enExample) * 1995-02-01 1997-11-11 Epix Medical Inc
DE19525924A1 (de) * 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
JPH10120597A (ja) * 1996-10-22 1998-05-12 Eiken Chem Co Ltd リンパ節高集積性コロイド粒子
DE69819925T2 (de) * 1997-10-02 2004-09-02 Epix Medical, Inc., Cambridge Kontrastverstärktes Diagnosebildererzeugungsverfahren zur Überwachung von therapeutischen Eingriffen
US6444192B1 (en) * 1999-02-05 2002-09-03 The Regents Of The University Of California Diagnostic imaging of lymph structures
AU5270500A (en) * 1999-05-14 2000-12-05 Regents Of The University Of California, The Macromolecular carrier for drug and diagnostic agent delivery
US6652835B1 (en) * 1999-07-29 2003-11-25 Epix Medical, Inc. Targeting multimeric imaging agents through multilocus binding
DE19948651B4 (de) * 1999-09-29 2006-10-05 Schering Ag Para- und diamagnetische perfluorhaltige Verbindungen enthaltende galenische Formulierungen, deren Herstellung und Verwendung
US6818203B2 (en) * 2000-08-11 2004-11-16 Schering Aktiengesellschaft Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
US7160535B2 (en) * 2001-10-31 2007-01-09 Bracco International Bv Conjugates of antioxidants with metal chelating ligands for use in diagnostic and therapeutic applications
US6549798B2 (en) * 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
US6705476B2 (en) * 2001-08-22 2004-03-16 Central Metal Products, Inc. Shipping rack with torsionally loaded shelf
US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
US8097283B2 (en) * 2004-01-15 2012-01-17 Mount Sinai School Of Medicine Methods and compositions for imaging

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113905659A (zh) * 2019-02-04 2022-01-07 麻省理工学院 用于淋巴结和血管成像的系统和方法

Also Published As

Publication number Publication date
EP2053968A4 (en) 2015-10-21
EP2053968A2 (en) 2009-05-06
JP5563299B2 (ja) 2014-07-30
KR20090045343A (ko) 2009-05-07
WO2008022263A3 (en) 2008-12-11
CA2660717A1 (en) 2008-02-21
WO2008022263A2 (en) 2008-02-21
US20080044358A1 (en) 2008-02-21
KR101336505B1 (ko) 2013-12-05
JP2010501009A (ja) 2010-01-14

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