JP2003505519A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003505519A5 JP2003505519A5 JP2001513442A JP2001513442A JP2003505519A5 JP 2003505519 A5 JP2003505519 A5 JP 2003505519A5 JP 2001513442 A JP2001513442 A JP 2001513442A JP 2001513442 A JP2001513442 A JP 2001513442A JP 2003505519 A5 JP2003505519 A5 JP 2003505519A5
- Authority
- JP
- Japan
- Prior art keywords
- kit
- contrast agent
- target
- sequence
- contrast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002872 contrast media Substances 0.000 description 32
- 239000008280 blood Substances 0.000 description 19
- 210000004369 blood Anatomy 0.000 description 19
- 230000003068 static effect Effects 0.000 description 16
- 238000003384 imaging method Methods 0.000 description 12
- 238000002583 angiography Methods 0.000 description 11
- 229910052760 oxygen Inorganic materials 0.000 description 11
- 239000002616 MRI contrast agent Substances 0.000 description 10
- 210000005166 vasculature Anatomy 0.000 description 9
- 238000000034 method Methods 0.000 description 8
- 229910021645 metal ion Inorganic materials 0.000 description 7
- 230000005298 paramagnetic effect Effects 0.000 description 7
- 230000005291 magnetic effect Effects 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 208000005189 Embolism Diseases 0.000 description 5
- 229910052799 carbon Inorganic materials 0.000 description 5
- 239000013522 chelant Substances 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 229910052717 sulfur Inorganic materials 0.000 description 5
- 102000009123 Fibrin Human genes 0.000 description 4
- 108010073385 Fibrin Proteins 0.000 description 4
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 4
- 208000007536 Thrombosis Diseases 0.000 description 4
- 125000003342 alkenyl group Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000000304 alkynyl group Chemical group 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 229950003499 fibrin Drugs 0.000 description 4
- 229910052736 halogen Inorganic materials 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 3
- 208000001435 Thromboembolism Diseases 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 229920001436 collagen Polymers 0.000 description 3
- 238000002059 diagnostic imaging Methods 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 125000005843 halogen group Chemical group 0.000 description 3
- 238000000264 spin echo pulse sequence Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- LDGWQMRUWMSZIU-LQDDAWAPSA-M 2,3-bis[(z)-octadec-9-enoxy]propyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCC\C=C/CCCCCCCCOCC(C[N+](C)(C)C)OCCCCCCCC\C=C/CCCCCCCC LDGWQMRUWMSZIU-LQDDAWAPSA-M 0.000 description 2
- HHLZCENAOIROSL-UHFFFAOYSA-N 2-[4,7-bis(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid Chemical compound OC(=O)CN1CCNCCN(CC(O)=O)CCN(CC(O)=O)CC1 HHLZCENAOIROSL-UHFFFAOYSA-N 0.000 description 2
- 206010002329 Aneurysm Diseases 0.000 description 2
- RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 2
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 description 2
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- 238000002075 inversion recovery Methods 0.000 description 2
- 230000005415 magnetization Effects 0.000 description 2
- 125000004433 nitrogen atom Chemical group N* 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 239000012216 imaging agent Substances 0.000 description 1
- 238000002595 magnetic resonance imaging Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229960003330 pentetic acid Drugs 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14641499P | 1999-07-29 | 1999-07-29 | |
| US16365099P | 1999-11-04 | 1999-11-04 | |
| US60/146,414 | 1999-11-04 | ||
| US60/163,650 | 1999-11-04 | ||
| PCT/US2000/020536 WO2001008712A2 (en) | 1999-07-29 | 2000-07-28 | Targeting multimeric imaging agents through multilocus binding |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002341392A Division JP2003201258A (ja) | 1999-07-29 | 2002-11-25 | 多座結合を介した多量体画像化剤の標的化 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003505519A JP2003505519A (ja) | 2003-02-12 |
| JP2003505519A5 true JP2003505519A5 (enExample) | 2006-01-05 |
Family
ID=26843871
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001513442A Pending JP2003505519A (ja) | 1999-07-29 | 2000-07-28 | 多座結合を介した多量体画像化剤の標的化 |
| JP2002341392A Pending JP2003201258A (ja) | 1999-07-29 | 2002-11-25 | 多座結合を介した多量体画像化剤の標的化 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002341392A Pending JP2003201258A (ja) | 1999-07-29 | 2002-11-25 | 多座結合を介した多量体画像化剤の標的化 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6652835B1 (enExample) |
| EP (1) | EP1210124A2 (enExample) |
| JP (2) | JP2003505519A (enExample) |
| KR (1) | KR20020057946A (enExample) |
| CN (2) | CN1382062A (enExample) |
| AU (1) | AU6386000A (enExample) |
| BR (1) | BR0013171A (enExample) |
| CA (1) | CA2384565A1 (enExample) |
| CZ (1) | CZ2002343A3 (enExample) |
| EA (1) | EA200200220A1 (enExample) |
| HK (1) | HK1048952A1 (enExample) |
| HU (1) | HUP0202635A3 (enExample) |
| IL (1) | IL147854A0 (enExample) |
| IS (1) | IS6241A (enExample) |
| MX (1) | MXPA02001017A (enExample) |
| NO (1) | NO20020474L (enExample) |
| NZ (1) | NZ517017A (enExample) |
| PL (1) | PL353336A1 (enExample) |
| WO (1) | WO2001008712A2 (enExample) |
| YU (1) | YU6502A (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW319763B (enExample) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
| CA2309749A1 (en) | 1997-11-17 | 1999-05-27 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| WO2001009188A1 (en) * | 1999-07-29 | 2001-02-08 | Dyax Corp. | Binding moieties for fibrin |
| US6652835B1 (en) * | 1999-07-29 | 2003-11-25 | Epix Medical, Inc. | Targeting multimeric imaging agents through multilocus binding |
| US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| WO2002006287A2 (en) | 2000-07-17 | 2002-01-24 | California Institute Of Technology | Macrocyclic mri contrast agents |
| US6670456B2 (en) * | 2001-02-28 | 2003-12-30 | Dow Global Technologies Inc. | Actinium-225 complexes and conjugates for targeted radiotherapy |
| TWI240632B (en) * | 2001-07-30 | 2005-10-01 | Epix Medical Inc | Purified peptides for peptide-based multimeric targeted contrast agents |
| TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| JP2005529839A (ja) * | 2001-10-16 | 2005-10-06 | エピックス メディカル， インコーポレイテッド | 脈管内病変の検出および処置 |
| US7504364B2 (en) * | 2002-03-01 | 2009-03-17 | Receptors Llc | Methods of making arrays and artificial receptors |
| DE10231799B4 (de) * | 2002-07-10 | 2006-10-05 | Schering Ag | Verwendung von perfluoralkylhaltigen Metallkomplexen als Kontrastmittel im MR-Imaging zur Darstellung von Intravasalen Thromben |
| US7344704B2 (en) | 2002-07-10 | 2008-03-18 | Schering Ag | Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi |
| US20050136483A1 (en) * | 2003-09-03 | 2005-06-23 | Receptors Llc | Nanodevices employing combinatorial artificial receptors |
| US20040137481A1 (en) * | 2002-09-16 | 2004-07-15 | Receptors Llc | Artificial receptor building blocks, components, and kits |
| US20050037381A1 (en) * | 2002-09-16 | 2005-02-17 | Receptors Llc | Artificial receptors, building blocks, and methods |
| US20060057625A1 (en) * | 2002-09-16 | 2006-03-16 | Carlson Robert E | Scaffold-based artificial receptors and methods |
| US7469076B2 (en) * | 2003-09-03 | 2008-12-23 | Receptors Llc | Sensors employing combinatorial artificial receptors |
| US20060051802A1 (en) * | 2002-09-16 | 2006-03-09 | Receptors Llc | Artificial receptors, building blocks, and methods |
| US20050037429A1 (en) * | 2003-03-28 | 2005-02-17 | Receptors Llc | Artificial receptors including reversibly immobilized building blocks and methods |
| EP1613737A4 (en) * | 2003-03-28 | 2008-12-03 | Receptors Llc | ARTIFICIAL RECEPTORS COMPRISING REVERSIBLE IMMOBILIZED CONSTRUCTION BLOCKS AND METHODS |
| CN1795015A (zh) | 2003-05-23 | 2006-06-28 | 埃匹克斯医药品股份有限公司 | 螯合配位体和造影剂的光学纯和光学富集异构体 |
| DE10325752A1 (de) * | 2003-06-06 | 2004-12-30 | Faustus Forschungs Cie. Translational Cancer Research Gmbh | Lektin-Konjugate |
| AR047692A1 (es) * | 2003-07-10 | 2006-02-08 | Epix Medical Inc | Imagenes de blancos estacionarios |
| CA2445420A1 (en) | 2003-07-29 | 2005-01-29 | Invitrogen Corporation | Kinase and phosphatase assays |
| US7619059B2 (en) | 2003-07-29 | 2009-11-17 | Life Technologies Corporation | Bimolecular optical probes |
| US7557577B2 (en) * | 2003-12-08 | 2009-07-07 | Siemens Aktiengesselschaft | Water-soluble paramagnetic substance reducing the relaxation time of the coolant in an MRI system |
| WO2005079274A2 (en) * | 2004-02-12 | 2005-09-01 | Mount Sinai School Of Medicine | Magnetic resonance imaging of atherosclerotic plaque |
| WO2006028930A2 (en) * | 2004-09-03 | 2006-03-16 | Receptors Llc | Combinatorial artificial receptors including tether building blocks on scaffolds |
| WO2006027244A2 (en) * | 2004-09-10 | 2006-03-16 | Bracco Imaging S.P.A. | Paramagnetic metal polyamino complexes for mri visualization of internalized polynucleotides |
| EP1789792A2 (en) | 2004-09-11 | 2007-05-30 | Receptors LLC | Combinatorial artificial receptors including peptide building blocks |
| WO2006056227A1 (en) * | 2004-11-27 | 2006-06-01 | Eberhard-Karls- Universität Tübingen Universitätsklinikum | Conjugates comprising the active agent and flanking or branched-chain peptides |
| DE102004062258B3 (de) * | 2004-12-23 | 2006-01-05 | Schering Ag | Hydroxypyridinon-Derivate, deren Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
| EP1836239B1 (en) | 2005-01-13 | 2008-10-29 | Cinvention Ag | Composite materials containing carbon nanoparticles |
| US20060275217A1 (en) * | 2005-05-06 | 2006-12-07 | Caravan Peter D | Chemical exchange saturation transfer contrast agents |
| CN101222878B (zh) * | 2005-07-13 | 2012-12-26 | 佐治亚州立大学研究基金会 | 显像剂及其制备方法 |
| AU2006303324A1 (en) * | 2005-10-18 | 2007-04-26 | Cinvention Ag | Thermoset particles and methods for production thereof |
| EP1955071A4 (en) | 2005-10-28 | 2009-03-18 | Invitrogen Corp | ASSAYS OF ACTIVITY KINASE AND UBIQUITINATION |
| US20070293656A1 (en) | 2005-12-29 | 2007-12-20 | Epix Pharmaceuticals, Inc. | Collagen binding peptides |
| US20080044358A1 (en) * | 2006-08-17 | 2008-02-21 | Vincent Jacques | Methods for lymph system imaging |
| EP2156186A4 (en) * | 2007-05-03 | 2010-11-03 | Tethys Bioscience Inc | BINDING REAGENTS WITH SMALL EPITOP BINDING MOLECULES |
| DE102007028090A1 (de) | 2007-06-12 | 2008-12-18 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Aktivierbare diagnostische und therapeutische Verbindung |
| WO2009023813A1 (en) * | 2007-08-15 | 2009-02-19 | Applied Soil Water Technologies Llc | Metals recovery from mining heap leach ore |
| US20090214436A1 (en) * | 2008-02-18 | 2009-08-27 | Washington University | Dichromic fluorescent compounds |
| US8722020B2 (en) | 2010-03-31 | 2014-05-13 | General Electric Company | Hydroxylated contrast enhancement agents |
| US8362281B2 (en) | 2010-03-31 | 2013-01-29 | General Electric Company | Intermediates for hydroxylated contrast enhancement agents |
| US8765977B2 (en) | 2010-03-31 | 2014-07-01 | General Electric Company | Hydroxylated contrast enhancement agents and imaging method |
| EP2806781B1 (en) | 2012-01-23 | 2018-03-21 | Washington University | Goggle imaging systems and methods |
| US9849201B2 (en) | 2013-05-03 | 2017-12-26 | Washington University | Homing agents |
| US10806804B2 (en) | 2015-05-06 | 2020-10-20 | Washington University | Compounds having RD targeting motifs and methods of use thereof |
| US10301358B2 (en) | 2015-06-29 | 2019-05-28 | Collagen Medical, LLC | Collagen imaging compositions |
| WO2017027834A1 (en) | 2015-08-13 | 2017-02-16 | The General Hospital Corporation | Manganese-based chelate conjugates for molecular mr imaging |
| EP3576801A4 (en) | 2017-02-02 | 2020-12-16 | The University of Akron | FUNCTIONALIZED POLY (PROPYLENE FUMARATE) POLYMERS MANUFACTURED BY CYCLE OPENING POLYMERIZATION USING MAGNESIUM CATALYSTS |
| EP4072598A4 (en) | 2019-12-13 | 2024-02-21 | Washington University | Near infrared fluorescent dyes, formulations and related methods |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880008A (en) | 1985-05-08 | 1989-11-14 | The General Hospital Corporation | Vivo enhancement of NMR relaxivity |
| US4777957A (en) * | 1985-06-14 | 1988-10-18 | General Electric Company | Method for measuring and imaging fluid flow |
| EP0247156B1 (en) * | 1985-11-18 | 1993-06-23 | Access Pharmaceuticals Inc. | Polychelating agents for image and spectral enhancement (and spectral shift) |
| DE3786000T3 (de) | 1986-08-18 | 1997-08-21 | Dow Chemical Co | Conjugate dichter Sterne. |
| US5011686A (en) * | 1987-09-21 | 1991-04-30 | Creative Biomolecules, Inc. | Thrombus specific conjugates |
| GB8808305D0 (en) * | 1988-04-08 | 1988-05-11 | Nycomed As | Compositions |
| US5914095A (en) | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
| ATE166864T1 (de) | 1989-10-23 | 1998-06-15 | Nycomed Salutar Inc | Mehrzähnige metall-chelatierende verbindungen |
| GB9320277D0 (en) | 1993-10-01 | 1993-11-17 | Nycomed Salutar Inc | Chelants |
| US5650133A (en) * | 1990-01-19 | 1997-07-22 | Nycomed Salutar | Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality |
| US5631329A (en) | 1990-08-27 | 1997-05-20 | Dendritech, Inc. | Process for producing hyper-comb-branched polymers |
| WO1992021017A1 (en) * | 1991-05-23 | 1992-11-26 | Unger Evan C | Liposoluble compounds for magnetic resonance imaging |
| JP2894879B2 (ja) * | 1991-10-04 | 1999-05-24 | 日本メジフィジックス株式会社 | 診断用造影剤 |
| US5522390A (en) * | 1991-11-21 | 1996-06-04 | U.S. Philips Corporation | Magnetic resonance imaging method |
| US5637759A (en) | 1992-07-30 | 1997-06-10 | The Regents Of The University Of California | Metal-ligating amino acid derivatives for MRI and for peptide synthesis |
| DE69332203T2 (de) | 1992-10-02 | 2003-05-28 | Diatide, Inc. | Multimerische mehrzweckwirkstoffe gegen thrombose |
| US5726304A (en) | 1992-10-30 | 1998-03-10 | The University Of British Columbia | Porphocyanine and CNC-expanded porphyrins |
| US5401493A (en) * | 1993-03-26 | 1995-03-28 | Molecular Biosystems, Inc. | Perfluoro-1H,-1H-neopentyl containing contrast agents and method to use same |
| US5579767A (en) * | 1993-06-07 | 1996-12-03 | Prince; Martin R. | Method for imaging abdominal aorta and aortic aneurysms |
| GB9314499D0 (en) * | 1993-07-12 | 1993-08-25 | Nycomed Imaging As | Method |
| GB9318550D0 (en) | 1993-09-07 | 1993-10-20 | Nycomed Salutar Inc | Chelants |
| DE4344460A1 (de) * | 1993-12-22 | 1995-06-29 | Schering Ag | Metallkomplexe von dendrimeren Makromolekülen, diese enthaltende diagnostische Mittel sowie Verfahren zur Herstellung der Komplexe und Mittel |
| IT1270994B (it) | 1994-03-18 | 1997-05-26 | Bracco Spa | Macromolecole ramificate a struttura poliossialchilica e loro usi |
| WO1995027705A1 (en) | 1994-04-08 | 1995-10-19 | Bracco International B.V. | Aromatic amide compounds and metal chelates thereof |
| GB9407812D0 (en) | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
| DE4425857A1 (de) * | 1994-07-07 | 1996-01-11 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| WO1998053855A1 (en) * | 1997-05-30 | 1998-12-03 | Alliance Pharmaceutical Corp. | Methods and apparatus for monitoring and quantifying the movement of fluid |
| US6232295B1 (en) | 1994-10-12 | 2001-05-15 | Jon Faiz Kayyem | Cell-specific contrast agent and gene delivery vehicles |
| TW319763B (enExample) * | 1995-02-01 | 1997-11-11 | Epix Medical Inc | |
| DE19518222A1 (de) | 1995-05-11 | 1996-11-14 | Schering Ag | Verwendung von polymeren Kontrastmittel mittleren Molekulargewichts zur Differenzierung von benignen und malignen Tumoren mittels moderner bildgebender Verfahren |
| DE19521945A1 (de) | 1995-06-12 | 1996-12-19 | Schering Ag | Kaskadenpolymere mit Iodaromaten |
| DE19525924A1 (de) * | 1995-07-04 | 1997-01-09 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US5919442A (en) | 1995-08-11 | 1999-07-06 | Dendritech, Inc. | Hyper comb-branched polymer conjugates |
| IT1277596B1 (it) | 1995-09-15 | 1997-11-11 | Bracco Spa | Composti macromolecolari di tipo dendrimerico |
| US6638508B2 (en) * | 1995-12-21 | 2003-10-28 | Yeda Research And Development Co., Ltd. | Modified avidin-type molecules as targeting agents for the liver and cells of the reticuloendothelial system |
| IT1283218B1 (it) * | 1996-03-08 | 1998-04-16 | Bracco Spa | Polichelanti, loro complessi con ioni metallici, loro preparazione e loro usi |
| PT907379E (pt) | 1996-04-01 | 2004-09-30 | Epix Medical Inc | Agentes de contraste bioactivados para imagiologia de diagnostico |
| WO1997041856A1 (en) | 1996-05-08 | 1997-11-13 | Massachusetts Institute Of Technology | ORGANOMETALLIC LIGANDS FOR THE LOCALIZATION AND QUANTIFICATION OF AMYLOID IN VIVO AND $i(IN VITRO) |
| DE19641197C2 (de) * | 1996-09-24 | 1999-02-18 | Schering Ag | Ionenpaare und ihre Verwendung als Kontrastmittel |
| NZ500273A (en) * | 1997-03-18 | 2001-12-21 | Nihon Schering Kabushiki Kaish | Gadolinium (Gd) polymer MRI contrast agent responsive to environmental changes |
| DE19731300C1 (de) * | 1997-07-11 | 1999-01-21 | Schering Ag | Perfluoralkylgruppenhaltige Trijodaromaten, Verfahren zu deren Herstellung und deren Verwendung als Kontrastmittel |
| US6073042A (en) * | 1997-09-25 | 2000-06-06 | Siemens Medical Systems, Inc. | Display of three-dimensional MRA images in which arteries can be distinguished from veins |
| CA2309749A1 (en) * | 1997-11-17 | 1999-05-27 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
| US6112112A (en) * | 1998-09-18 | 2000-08-29 | Arch Development Corporation | Method and system for the assessment of tumor extent in magnetic resonance images |
| US6342598B1 (en) * | 1998-11-26 | 2002-01-29 | Bracco International B.V. | Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents |
| US6458953B1 (en) * | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
| US6399578B1 (en) * | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
| WO2001009188A1 (en) * | 1999-07-29 | 2001-02-08 | Dyax Corp. | Binding moieties for fibrin |
| US6652835B1 (en) * | 1999-07-29 | 2003-11-25 | Epix Medical, Inc. | Targeting multimeric imaging agents through multilocus binding |
| EP1379885A4 (en) * | 2001-01-05 | 2005-07-06 | Univ Duke | CONTRAST REINFORCING AGENT FOR MAGNETIC RESONANCE IMAGING |
| US6459264B1 (en) * | 2001-02-22 | 2002-10-01 | Mayo Foundation For Medical Education And Research | Real-time embedded magnetic resonance fluoroscopy |
| JP2005534697A (ja) * | 2002-08-06 | 2005-11-17 | エピックス ファーマシューティカルズ， インコーポレイテッド | ペプチド凝集体 |
-
2000
- 2000-07-28 US US09/627,719 patent/US6652835B1/en not_active Expired - Fee Related
- 2000-07-28 CN CN00813045A patent/CN1382062A/zh active Pending
- 2000-07-28 YU YU6502A patent/YU6502A/sh unknown
- 2000-07-28 HU HU0202635A patent/HUP0202635A3/hu unknown
- 2000-07-28 PL PL00353336A patent/PL353336A1/xx not_active Application Discontinuation
- 2000-07-28 EP EP00950815A patent/EP1210124A2/en not_active Withdrawn
- 2000-07-28 HK HK03101252.8A patent/HK1048952A1/zh unknown
- 2000-07-28 CN CNA2004100567047A patent/CN1626246A/zh active Pending
- 2000-07-28 BR BR0013171-7A patent/BR0013171A/pt not_active IP Right Cessation
- 2000-07-28 JP JP2001513442A patent/JP2003505519A/ja active Pending
- 2000-07-28 NZ NZ517017A patent/NZ517017A/en unknown
- 2000-07-28 AU AU63860/00A patent/AU6386000A/en not_active Abandoned
- 2000-07-28 CA CA002384565A patent/CA2384565A1/en not_active Abandoned
- 2000-07-28 KR KR1020027001126A patent/KR20020057946A/ko not_active Withdrawn
- 2000-07-28 EA EA200200220A patent/EA200200220A1/ru unknown
- 2000-07-28 WO PCT/US2000/020536 patent/WO2001008712A2/en not_active Ceased
- 2000-07-28 MX MXPA02001017A patent/MXPA02001017A/es unknown
- 2000-07-28 IL IL14785400A patent/IL147854A0/xx unknown
- 2000-07-28 CZ CZ2002343A patent/CZ2002343A3/cs unknown
-
2002
- 2002-01-18 IS IS6241A patent/IS6241A/is unknown
- 2002-01-29 NO NO20020474A patent/NO20020474L/no not_active Application Discontinuation
- 2002-11-25 JP JP2002341392A patent/JP2003201258A/ja active Pending
-
2003
- 2003-05-27 US US10/445,544 patent/US20040005274A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003505519A5 (enExample) | ||
| Bremerich et al. | MR angiography with blood pool contrast agents | |
| Kiessling et al. | Contrast agents and applications to assess tumor angiogenesis in vivo by magnetic resonance imaging | |
| US11110185B2 (en) | Combination formulation | |
| JPH082802B2 (ja) | 磁気共鳴イメージングに関する改良 | |
| US5466439A (en) | Polymeric contrast enhancing agents for magnetic resonance images | |
| JP2001518523A5 (enExample) | ||
| JPH09502426A (ja) | 像コントラスト増強のための方法および組成物 | |
| EP0580734A1 (en) | Melanin-based agents for image enhancement | |
| Xue et al. | Design of ProCAs (Protein‐Based Gd3+ MRI Contrast Agents) with High Dose Efficiency and Capability for Molecular Imaging of Cancer Biomarkers | |
| KR101336505B1 (ko) | 림프계의 영상화 방법 | |
| Runge et al. | The developmental history of the gadolinium chelates as intravenous contrast media for magnetic resonance | |
| Katzberg et al. | Functional, dynamic, and anatomic MR urography: feasibility and preliminary findings | |
| JP2010501009A5 (enExample) | ||
| Watson | The use of gadolinium and dysprosium chelate complexes as contrast agents for magnetic resonance imaging | |
| LeBedis et al. | Use of magnetic resonance imaging contrast agents in the liver and biliary tract | |
| Adzamli et al. | Phosphonate‐modified Gd‐DTPA complexes. III: The detection of myocardial infarction by MRI | |
| US20050171424A1 (en) | Methods for imaging the lymphatic system using dendrimer-based contrast agents | |
| JP4786112B2 (ja) | 金属イオンキレート化錯体と共役させた胆汁酸誘導体の微小血管の診断評価のための使用 | |
| CN100459932C (zh) | 一种mri分子影像探针及其制备方法 | |
| Yoshikawa et al. | Contrast-enhanced MR angiography in rats with hepatobiliary contrast agents | |
| JP3152706B2 (ja) | 心筋特異性を有するｍｒｉ造影剤 | |
| Froehlich | MR contrast agents | |
| Runge et al. | Magnetic resonance contrast agents in neuroimaging: New agents and applications | |
| Balzer | Contrast agents for magnetic resonance imaging |