YU6502A - Usmeravanje multimernih agenasa za dobijanje kontrasta pri dijagnostičkom snimanju putem multilokusnog vezivanja - Google Patents
Usmeravanje multimernih agenasa za dobijanje kontrasta pri dijagnostičkom snimanju putem multilokusnog vezivanjaInfo
- Publication number
- YU6502A YU6502A YU6502A YUP6502A YU6502A YU 6502 A YU6502 A YU 6502A YU 6502 A YU6502 A YU 6502A YU P6502 A YUP6502 A YU P6502A YU 6502 A YU6502 A YU 6502A
- Authority
- YU
- Yugoslavia
- Prior art keywords
- compounds
- relates
- moieties
- binding
- iems
- Prior art date
Links
- 239000012216 imaging agent Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 238000002059 diagnostic imaging Methods 0.000 abstract 2
- 239000002872 contrast media Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000004807 localization Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0052—Small organic molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/12—Macromolecular compounds
- A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
- A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Predmetni pronalazak se odnosi na agense za ostvarivanje kontrasta pri dijagnostickom snimanju. Posebno, predmetni pronalazak se odnosi na nova multimerna jedinjenja koja pokazuju povecanu relaksivost nakon vezivanja za endogene proteine ili druga fizioloski relevantna mesta. Ova jedinjenja se sastoje od: a) dva ili vise hemijskih ostataka za poboljsavanje snimka (IEM-ova) (ili hemijskih ostataka za generisanje signala) koji sadrze visestruke podjedinice, b) dva ili vise hemijskih ostataka za vezivanje za ciljnu strukturu (TBM-ova) koji obezbedjuju in vivo lokalizaciju i ucvrscavanje multimera, c) hemijsku skeletnu strukturu za vezivanje gore pomenutih ostataka i d) opcione veznike za vezivanje IEM-ova za skeletnu strukturu. Predmetni pronlazak se takodje odnosi na farmaceutske preparate koji sadrze ova jedinjenja i na postupke upotrebe ovih jedinjenja i preparata za kontrastno pojacavanje tokom snimanja.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14641499P | 1999-07-29 | 1999-07-29 | |
US16365099P | 1999-11-04 | 1999-11-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
YU6502A true YU6502A (sh) | 2005-06-10 |
Family
ID=26843871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU6502A YU6502A (sh) | 1999-07-29 | 2000-07-28 | Usmeravanje multimernih agenasa za dobijanje kontrasta pri dijagnostičkom snimanju putem multilokusnog vezivanja |
Country Status (20)
Country | Link |
---|---|
US (2) | US6652835B1 (sh) |
EP (1) | EP1210124A2 (sh) |
JP (2) | JP2003505519A (sh) |
KR (1) | KR20020057946A (sh) |
CN (2) | CN1382062A (sh) |
AU (1) | AU6386000A (sh) |
BR (1) | BR0013171A (sh) |
CA (1) | CA2384565A1 (sh) |
CZ (1) | CZ2002343A3 (sh) |
EA (1) | EA200200220A1 (sh) |
HK (1) | HK1048952A1 (sh) |
HU (1) | HUP0202635A3 (sh) |
IL (1) | IL147854A0 (sh) |
IS (1) | IS6241A (sh) |
MX (1) | MXPA02001017A (sh) |
NO (1) | NO20020474L (sh) |
NZ (1) | NZ517017A (sh) |
PL (1) | PL353336A1 (sh) |
WO (1) | WO2001008712A2 (sh) |
YU (1) | YU6502A (sh) |
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2000
- 2000-07-28 PL PL00353336A patent/PL353336A1/xx not_active Application Discontinuation
- 2000-07-28 MX MXPA02001017A patent/MXPA02001017A/es unknown
- 2000-07-28 KR KR1020027001126A patent/KR20020057946A/ko not_active Application Discontinuation
- 2000-07-28 YU YU6502A patent/YU6502A/sh unknown
- 2000-07-28 HU HU0202635A patent/HUP0202635A3/hu unknown
- 2000-07-28 IL IL14785400A patent/IL147854A0/xx unknown
- 2000-07-28 NZ NZ517017A patent/NZ517017A/en unknown
- 2000-07-28 US US09/627,719 patent/US6652835B1/en not_active Expired - Fee Related
- 2000-07-28 JP JP2001513442A patent/JP2003505519A/ja active Pending
- 2000-07-28 WO PCT/US2000/020536 patent/WO2001008712A2/en not_active Application Discontinuation
- 2000-07-28 CN CN00813045A patent/CN1382062A/zh active Pending
- 2000-07-28 CN CNA2004100567047A patent/CN1626246A/zh active Pending
- 2000-07-28 EP EP00950815A patent/EP1210124A2/en not_active Withdrawn
- 2000-07-28 CA CA002384565A patent/CA2384565A1/en not_active Abandoned
- 2000-07-28 EA EA200200220A patent/EA200200220A1/ru unknown
- 2000-07-28 BR BR0013171-7A patent/BR0013171A/pt not_active IP Right Cessation
- 2000-07-28 AU AU63860/00A patent/AU6386000A/en not_active Abandoned
- 2000-07-28 CZ CZ2002343A patent/CZ2002343A3/cs unknown
-
2002
- 2002-01-18 IS IS6241A patent/IS6241A/is unknown
- 2002-01-29 NO NO20020474A patent/NO20020474L/no not_active Application Discontinuation
- 2002-11-25 JP JP2002341392A patent/JP2003201258A/ja active Pending
-
2003
- 2003-02-19 HK HK03101252.8A patent/HK1048952A1/zh unknown
- 2003-05-27 US US10/445,544 patent/US20040005274A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP1210124A2 (en) | 2002-06-05 |
CZ2002343A3 (cs) | 2002-08-14 |
NO20020474D0 (no) | 2002-01-29 |
HUP0202635A3 (en) | 2006-03-28 |
JP2003505519A (ja) | 2003-02-12 |
US20040005274A1 (en) | 2004-01-08 |
KR20020057946A (ko) | 2002-07-12 |
NO20020474L (no) | 2002-03-27 |
CN1382062A (zh) | 2002-11-27 |
AU6386000A (en) | 2001-02-19 |
US6652835B1 (en) | 2003-11-25 |
CN1626246A (zh) | 2005-06-15 |
CA2384565A1 (en) | 2001-02-08 |
EA200200220A1 (ru) | 2002-08-29 |
JP2003201258A (ja) | 2003-07-18 |
WO2001008712A2 (en) | 2001-02-08 |
IL147854A0 (en) | 2002-08-14 |
BR0013171A (pt) | 2002-05-28 |
PL353336A1 (en) | 2003-11-17 |
NZ517017A (en) | 2004-05-28 |
WO2001008712A3 (en) | 2002-03-14 |
IS6241A (is) | 2002-01-18 |
MXPA02001017A (es) | 2002-08-12 |
HUP0202635A2 (hu) | 2002-11-28 |
HK1048952A1 (zh) | 2003-04-25 |
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