YU6502A - Usmeravanje multimernih agenasa za dobijanje kontrasta pri dijagnostičkom snimanju putem multilokusnog vezivanja - Google Patents

Usmeravanje multimernih agenasa za dobijanje kontrasta pri dijagnostičkom snimanju putem multilokusnog vezivanja

Info

Publication number
YU6502A
YU6502A YU6502A YUP6502A YU6502A YU 6502 A YU6502 A YU 6502A YU 6502 A YU6502 A YU 6502A YU P6502 A YUP6502 A YU P6502A YU 6502 A YU6502 A YU 6502A
Authority
YU
Yugoslavia
Prior art keywords
compounds
relates
moieties
binding
iems
Prior art date
Application number
YU6502A
Other languages
English (en)
Inventor
Randall B. Lauffer
Thomas J. Mcmurry
Stephane Dumas
Andrew Kolodziej
John Amedio
Peter Caravan
Zhaoda Zhang
Shrikumar Nair
Original Assignee
Epix Medical Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Medical Inc. filed Critical Epix Medical Inc.
Publication of YU6502A publication Critical patent/YU6502A/sh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Predmetni pronalazak se odnosi na agense za ostvarivanje kontrasta pri dijagnostickom snimanju. Posebno, predmetni pronalazak se odnosi na nova multimerna jedinjenja koja pokazuju povecanu relaksivost nakon vezivanja za endogene proteine ili druga fizioloski relevantna mesta. Ova jedinjenja se sastoje od: a) dva ili vise hemijskih ostataka za poboljsavanje snimka (IEM-ova) (ili hemijskih ostataka za generisanje signala) koji sadrze visestruke podjedinice, b) dva ili vise hemijskih ostataka za vezivanje za ciljnu strukturu (TBM-ova) koji obezbedjuju in vivo lokalizaciju i ucvrscavanje multimera, c) hemijsku skeletnu strukturu za vezivanje gore pomenutih ostataka i d) opcione veznike za vezivanje IEM-ova za skeletnu strukturu. Predmetni pronlazak se takodje odnosi na farmaceutske preparate koji sadrze ova jedinjenja i na postupke upotrebe ovih jedinjenja i preparata za kontrastno pojacavanje tokom snimanja.
YU6502A 1999-07-29 2000-07-28 Usmeravanje multimernih agenasa za dobijanje kontrasta pri dijagnostičkom snimanju putem multilokusnog vezivanja YU6502A (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14641499P 1999-07-29 1999-07-29
US16365099P 1999-11-04 1999-11-04

Publications (1)

Publication Number Publication Date
YU6502A true YU6502A (sh) 2005-06-10

Family

ID=26843871

Family Applications (1)

Application Number Title Priority Date Filing Date
YU6502A YU6502A (sh) 1999-07-29 2000-07-28 Usmeravanje multimernih agenasa za dobijanje kontrasta pri dijagnostičkom snimanju putem multilokusnog vezivanja

Country Status (20)

Country Link
US (2) US6652835B1 (sh)
EP (1) EP1210124A2 (sh)
JP (2) JP2003505519A (sh)
KR (1) KR20020057946A (sh)
CN (2) CN1382062A (sh)
AU (1) AU6386000A (sh)
BR (1) BR0013171A (sh)
CA (1) CA2384565A1 (sh)
CZ (1) CZ2002343A3 (sh)
EA (1) EA200200220A1 (sh)
HK (1) HK1048952A1 (sh)
HU (1) HUP0202635A3 (sh)
IL (1) IL147854A0 (sh)
IS (1) IS6241A (sh)
MX (1) MXPA02001017A (sh)
NO (1) NO20020474L (sh)
NZ (1) NZ517017A (sh)
PL (1) PL353336A1 (sh)
WO (1) WO2001008712A2 (sh)
YU (1) YU6502A (sh)

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Also Published As

Publication number Publication date
WO2001008712A2 (en) 2001-02-08
JP2003201258A (ja) 2003-07-18
CN1626246A (zh) 2005-06-15
IS6241A (is) 2002-01-18
HK1048952A1 (zh) 2003-04-25
IL147854A0 (en) 2002-08-14
WO2001008712A3 (en) 2002-03-14
HUP0202635A2 (hu) 2002-11-28
EA200200220A1 (ru) 2002-08-29
US20040005274A1 (en) 2004-01-08
CN1382062A (zh) 2002-11-27
AU6386000A (en) 2001-02-19
CZ2002343A3 (cs) 2002-08-14
EP1210124A2 (en) 2002-06-05
NO20020474L (no) 2002-03-27
BR0013171A (pt) 2002-05-28
MXPA02001017A (es) 2002-08-12
NZ517017A (en) 2004-05-28
NO20020474D0 (no) 2002-01-29
HUP0202635A3 (en) 2006-03-28
KR20020057946A (ko) 2002-07-12
JP2003505519A (ja) 2003-02-12
US6652835B1 (en) 2003-11-25
PL353336A1 (en) 2003-11-17
CA2384565A1 (en) 2001-02-08

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