DE3786000T3 - Conjugate dichter Sterne. - Google Patents
Conjugate dichter Sterne.Info
- Publication number
- DE3786000T3 DE3786000T3 DE3786000T DE3786000T DE3786000T3 DE 3786000 T3 DE3786000 T3 DE 3786000T3 DE 3786000 T DE3786000 T DE 3786000T DE 3786000 T DE3786000 T DE 3786000T DE 3786000 T3 DE3786000 T3 DE 3786000T3
- Authority
- DE
- Germany
- Prior art keywords
- stars
- conjugate
- dense
- dendrimer
- conjugates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
- A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/02—Polyamines
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
- C08G83/003—Dendrimers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L101/00—Compositions of unspecified macromolecular compounds
- C08L101/005—Dendritic macromolecules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Nanotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Pest Control & Pesticides (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Agronomy & Crop Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Polyamides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89745586A | 1986-08-18 | 1986-08-18 |
Publications (3)
Publication Number | Publication Date |
---|---|
DE3786000D1 DE3786000D1 (de) | 1993-07-01 |
DE3786000T2 DE3786000T2 (de) | 1993-09-02 |
DE3786000T3 true DE3786000T3 (de) | 1997-08-21 |
Family
ID=25407923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3786000T Expired - Lifetime DE3786000T3 (de) | 1986-08-18 | 1987-08-17 | Conjugate dichter Sterne. |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0271180B2 (de) |
JP (6) | JPH072840B2 (de) |
KR (1) | KR970011151B1 (de) |
AT (1) | ATE89743T1 (de) |
AU (2) | AU609051B2 (de) |
BR (3) | BR8707431A (de) |
DE (1) | DE3786000T3 (de) |
DK (1) | DK174053B1 (de) |
ES (1) | ES2054678T5 (de) |
FI (2) | FI103410B1 (de) |
GR (1) | GR3024215T3 (de) |
HK (1) | HK54396A (de) |
HU (2) | HU209252B (de) |
IE (1) | IE61356B1 (de) |
IL (1) | IL83567A (de) |
MX (1) | MX169992B (de) |
MY (1) | MY102878A (de) |
NO (1) | NO176306C (de) |
NZ (1) | NZ221484A (de) |
WO (3) | WO1988001180A1 (de) |
ZA (1) | ZA876114B (de) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5560929A (en) * | 1986-08-18 | 1996-10-01 | The Dow Chemical Company | Structured copolymers and their use as absorbents, gels and carriers of metal ions |
WO1995024221A1 (en) * | 1986-08-18 | 1995-09-14 | The Dow Chemical Company | Bioactive and/or targeted dendrimer conjugates |
US5914095A (en) * | 1989-04-07 | 1999-06-22 | Salutar, Inc. | Polychelants containg amide bonds |
ES2080160T3 (es) * | 1989-05-26 | 1996-02-01 | Akzo Nobel Nv | Agentes quelantes para union de metales a proteinas. |
US5808003A (en) * | 1989-05-26 | 1998-09-15 | Perimmune Holdings, Inc. | Polyaminocarboxylate chelators |
US5292868A (en) * | 1989-05-26 | 1994-03-08 | Akzo N.V. | Chelating agents for attaching metal ions to proteins |
DE3930674A1 (de) * | 1989-09-11 | 1991-03-21 | Diagnostikforschung Inst | Bifunktionelle chelatbildner zur komplexierung von tc- und re-isotopen, verfahren zu ihrer herstellung und darstellung von konjugaten daraus sowie deren verwendung in diagnostik und therapie |
DE3938992A1 (de) | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
AU641736B2 (en) * | 1990-03-21 | 1993-09-30 | Quest International B.V. | Delivery of agents |
AU642980B2 (en) * | 1990-03-21 | 1993-11-04 | Quest International B.V. | Ultilization of enzymes |
AU642979B2 (en) * | 1990-03-21 | 1993-11-04 | Quest International B.V. | Utilization and delivery of enzymes |
GB9021671D0 (en) * | 1990-10-05 | 1990-11-21 | Unilever Plc | Delivery of agents |
IL99234A (en) * | 1990-08-27 | 1994-05-30 | Michigan Molecular Inst | Non-cross-linked multi-branch polymers and their preparation |
GB9112536D0 (en) * | 1991-06-11 | 1991-07-31 | Celltech Ltd | Chemical compounds |
FR2688508A1 (fr) * | 1992-03-13 | 1993-09-17 | Guerbet Sa | Nouveau produit de contraste iode, son procede de preparation et son utilisation comme agent de contraste. |
US5871713A (en) * | 1991-12-04 | 1999-02-16 | Guerbet S.A. | Macromolecular polyamine iodine-containing compound, process for its preparation and its use as a contrast agent |
CA2125188A1 (fr) * | 1991-12-04 | 1993-06-10 | Dominique Meyer | Nouveau compose macromoleculaire polyamine iode, son procede de preparation et son utilisation comme agent de contraste |
CA2118130A1 (en) | 1992-04-14 | 1993-10-28 | Jean M. J. Frechet | Dendritic based macromolecules and method of production |
US5387617A (en) * | 1993-01-22 | 1995-02-07 | The Dow Chemical Company | Small cell foams and blends and a process for their preparation |
US6121056A (en) * | 1993-02-24 | 2000-09-19 | Dade Behring Inc. | Random detection of antigens with antibodies immobilized on soluble submicron particles |
US5898005A (en) * | 1993-02-24 | 1999-04-27 | Dade Behring Inc. | Rapid detection of analytes with receptors immobilized on soluble submicron particles |
JP3366978B2 (ja) * | 1993-02-24 | 2003-01-14 | デイド、ベーリング、インコーポレイテッド | 特異的結合性アッセイ試薬の固定化 |
FR2703055B1 (fr) * | 1993-03-22 | 1995-07-07 | Guerbet Sa | Nouveaux composés polyiodés, leur préparation et leur utilisation en tant que produits de contraste pour la radiologie . |
US7097839B1 (en) | 1993-10-26 | 2006-08-29 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
AU750411B2 (en) * | 1994-03-07 | 2002-07-18 | Dendritic Nanotechnologies, Inc. | Bioactive and/or targeted dendrimer conjugates |
GB9407812D0 (en) * | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
NL9400880A (nl) * | 1994-05-27 | 1996-01-02 | Dsm Nv | Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijstellen van de actieve stof. |
NL9401886A (nl) * | 1994-05-27 | 1996-01-02 | Dsm Nv | Samenstelling bestaande uit een dendrimeer en een in het dendrimeer opgesloten actieve stof, een werkwijze voor de bereiding van een dergelijke samenstelling en een werkwijze voor het vrijgeven van de actieve stof. |
AUPM623994A0 (en) | 1994-06-15 | 1994-07-07 | Biomolecular Research Institute Limited | Antiviral dendrimers |
CA2206915A1 (en) * | 1994-12-21 | 1996-06-27 | Konstantinos Skobridis | Oligonucleotide-dendrimer conjugates |
FR2734268B1 (fr) * | 1995-05-19 | 1997-07-04 | Centre Nat Rech Scient | Nouveaux dendrimeres fonctionnels a terminaisons phosphorees et leur procede de preparation |
US6051429A (en) | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
US6083708A (en) * | 1995-08-11 | 2000-07-04 | Dade Behring Inc. | Polypeptide: dendrimer complexes |
US5658574A (en) * | 1995-10-13 | 1997-08-19 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cleansing compositions with dendrimers as mildness agents |
NL1001753C2 (nl) * | 1995-11-28 | 1997-05-30 | Dsm Nv | Samenstelling omvattende een kunststof en een additief. |
DE19625982A1 (de) * | 1996-06-28 | 1998-01-02 | Wella Ag | Kosmetisches Mittel zur Haarbehandlung mit Dendrimeren |
CA2274458A1 (en) * | 1997-01-13 | 1998-07-16 | Dendritech, Inc. | Nanocomposites of dendritic polymers |
WO1998056427A1 (fr) * | 1997-06-12 | 1998-12-17 | Mitsubishi Chemical Corporation | Agent de contrast |
DE19728954C1 (de) * | 1997-06-30 | 1999-04-22 | Schering Ag | Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung |
FR2790642A1 (fr) * | 1999-03-08 | 2000-09-15 | Aventis Cropscience Sa | Nouvelles compositions pesticides et/ou regulatrices de croissance |
JP2003503591A (ja) * | 1999-06-29 | 2003-01-28 | ダコ エー エス | 標識およびプローブを保持するデンドリマーを用いた検出 |
CZ2002343A3 (cs) | 1999-07-29 | 2002-08-14 | Epix Medical, Inc. | Cílená multimerní zobrazovací činidla s multilokální vazebnou schopností |
FI19991705A (fi) * | 1999-08-11 | 2001-02-12 | Neste Chemicals Oy | Antimikrobinen hyperhaaroittunut polymeerikoostumus |
FR2797563A1 (fr) * | 1999-08-18 | 2001-02-23 | Rhodianyl | Composes biocides et leur utilisation dans des polymeres thermoplastiques |
ES2323667T3 (es) * | 1999-12-10 | 2009-07-23 | Gerald M. Rosen | Uso de dendrimeros funcionalizados con poli-nitroxilo como agentes intensificadores del contraste en la obtencion de imagenes mri de las articulaciones. |
CN1218022C (zh) | 2000-04-07 | 2005-09-07 | 国际壳牌研究有限公司 | 抑制管道被气体水合物堵塞的方法 |
US6471968B1 (en) * | 2000-05-12 | 2002-10-29 | Regents Of The University Of Michigan | Multifunctional nanodevice platform |
CU23011A1 (es) * | 2000-11-03 | 2004-12-17 | Ct Ingenieria Genetica Biotech | Método de obtención de estructuras antigénicas quemétodo de obtención de estructuras antigénicas que potencian la reactividad cruzada específica y su potencian la reactividad cruzada específica y su uso en formulaciones uso en formulaciones |
CA2450162A1 (en) | 2001-06-14 | 2002-12-27 | Shell Internationale Research Maatschappij B.V. | Method for solubilising asphaltenes in a hydrocarbon mixture |
TWI221406B (en) | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
GB0209022D0 (en) | 2002-04-19 | 2002-05-29 | Imp College Innovations Ltd | Compounds |
CA2497366A1 (en) | 2002-09-03 | 2004-03-18 | Shell Canada Limited | Method and compositions for inhibiting formation of hydrocarbon hydrates |
EP1525890A1 (de) | 2003-10-02 | 2005-04-27 | Complex Biosystems GmbH | Protein-Proteophor Komplex |
EP1697543B1 (de) * | 2003-11-21 | 2014-08-20 | ANP Technologies, Inc. | Asymmetrisch verzweigte polymerkonjugate und mikroarray-tests |
WO2006065266A2 (en) | 2004-04-20 | 2006-06-22 | Dendritic Nanotechnologies, Inc. | Dendritic polymers with enhanced amplification and interior functionality |
US7985424B2 (en) | 2004-04-20 | 2011-07-26 | Dendritic Nanotechnologies Inc. | Dendritic polymers with enhanced amplification and interior functionality |
JP5329755B2 (ja) | 2004-08-13 | 2013-10-30 | 日本曹達株式会社 | 多分岐ポリマー |
JP2008510829A (ja) * | 2004-08-25 | 2008-04-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | デンドリマーに基づく組成物およびそれらの使用法 |
EP1656840B1 (de) | 2004-11-08 | 2008-05-14 | FUJIFILM Corporation | Verwendung eines Mittels zur Beseitigung vom Sauerstoff |
CN101065466B (zh) | 2004-11-24 | 2013-02-13 | 国际壳牌研究有限公司 | 改进含有蜡和其它烃的混合物的流动性的方法 |
JP2008545621A (ja) * | 2005-04-20 | 2008-12-18 | デンドリティック ナノテクノロジーズ,インコーポレイテッド | 強化された拡大性と内部官能基性をもった樹枝状ポリマー |
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CN101258184B (zh) | 2005-09-07 | 2012-05-23 | 日本曹达株式会社 | 星形聚合物及其制造方法 |
WO2007061896A1 (en) | 2005-11-17 | 2007-05-31 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
KR100976754B1 (ko) | 2006-07-11 | 2010-08-18 | 닛뽕소다 가부시키가이샤 | 스타 폴리머 및 그 제조 방법 |
US20080020043A1 (en) * | 2006-07-20 | 2008-01-24 | Marc Gingras | Dendrimer-Drug Conjugates |
US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
US8658148B2 (en) | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
KR101176813B1 (ko) | 2007-08-31 | 2012-08-24 | 닛뽕소다 가부시키가이샤 | 스타 폴리머의 제조 방법 |
US8252834B2 (en) | 2008-03-12 | 2012-08-28 | The Regents Of The University Of Michigan | Dendrimer conjugates |
JP2011518881A (ja) | 2008-04-28 | 2011-06-30 | ゾゲニクス インコーポレーティッド | 片頭痛の治療のための製剤 |
US8889635B2 (en) | 2008-09-30 | 2014-11-18 | The Regents Of The University Of Michigan | Dendrimer conjugates |
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GB2122641B (en) * | 1982-06-07 | 1986-08-06 | Otto A Gansow | Metal chelate conjugated monoclonal antibodies where in the metal is an emitter |
US4558120A (en) * | 1983-01-07 | 1985-12-10 | The Dow Chemical Company | Dense star polymer |
US4507466A (en) * | 1983-01-07 | 1985-03-26 | The Dow Chemical Corporation | Dense star polymers having core, core branches, terminal groups |
US4631337A (en) * | 1983-01-07 | 1986-12-23 | The Dow Chemical Company | Hydrolytically-stable dense star polyamine |
US4606907A (en) * | 1984-07-02 | 1986-08-19 | The Dow Chemical Company | Bone seeking Tc-99m complexes of phosphonate derivatives of polyamidoamines |
US4599400A (en) * | 1984-12-18 | 1986-07-08 | The Dow Chemical Company | Star/comb-branched polyamide |
US4694064A (en) * | 1986-02-28 | 1987-09-15 | The Dow Chemical Company | Rod-shaped dendrimer |
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Owner name: DENDRITIC NANOTECHNOLOGIES, INC., MT. PLEASANT, MI |