MX169992B - Conjugados de estrella explotada - Google Patents

Conjugados de estrella explotada

Info

Publication number
MX169992B
MX169992B MX007801A MX780187A MX169992B MX 169992 B MX169992 B MX 169992B MX 007801 A MX007801 A MX 007801A MX 780187 A MX780187 A MX 780187A MX 169992 B MX169992 B MX 169992B
Authority
MX
Mexico
Prior art keywords
conjugates
exploited
star
dendrimer
agricutural
Prior art date
Application number
MX007801A
Other languages
English (en)
Inventor
Roberta C Cheng
Iuan A Tomlinson
Michael J Fazio
David M Hedstrand
Donald A Tomalia
Donald A Kaplan
William J Kruper
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25407923&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX169992(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of MX169992B publication Critical patent/MX169992B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
    • A01N25/10—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6883—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy
    • A61K47/6885—Polymer-drug antibody conjugates, e.g. mitomycin-dextran-Ab; DNA-polylysine-antibody complex or conjugate used for therapy the conjugate or the polymer being a starburst, a dendrimer, a cascade
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002—Dendritic macromolecules
    • C08G83/003—Dendrimers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L101/00—Compositions of unspecified macromolecular compounds
    • C08L101/005—Dendritic macromolecules

Abstract

La presente invención se refiere a un conjugado de estrella explotada que comprende al menos un polímero de estrella explotada asociado con al menos una unidad de al menos un material farmaceutico portado. El conjugado donde el polímero de estrella explotada es un dendrímero de estrella explotada. El conjugado donde al menos uno de los materiales farmaceuticos portados es un medicamento, radionúclido, quelator, metal quelado, toxina, anticuerpo, fragmento de anticuerpo, antígeno, generador de señales, reflector de señales o absorbedor de señales.
MX007801A 1986-08-18 1987-08-18 Conjugados de estrella explotada MX169992B (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89745586A 1986-08-18 1986-08-18

Publications (1)

Publication Number Publication Date
MX169992B true MX169992B (es) 1993-08-04

Family

ID=25407923

Family Applications (1)

Application Number Title Priority Date Filing Date
MX007801A MX169992B (es) 1986-08-18 1987-08-18 Conjugados de estrella explotada

Country Status (21)

Country Link
EP (1) EP0271180B2 (es)
JP (6) JPH0757736B2 (es)
KR (1) KR970011151B1 (es)
AT (1) ATE89743T1 (es)
AU (2) AU609051B2 (es)
BR (3) BR8707432A (es)
DE (1) DE3786000T3 (es)
DK (1) DK174053B1 (es)
ES (1) ES2054678T5 (es)
FI (2) FI103410B (es)
GR (1) GR3024215T3 (es)
HK (1) HK54396A (es)
HU (2) HU209252B (es)
IE (1) IE61356B1 (es)
IL (1) IL83567A (es)
MX (1) MX169992B (es)
MY (1) MY102878A (es)
NO (1) NO176306C (es)
NZ (1) NZ221484A (es)
WO (3) WO1988001178A1 (es)
ZA (1) ZA876114B (es)

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AU638153B2 (en) 1993-06-17
ATE89743T1 (de) 1993-06-15
FI103410B1 (fi) 1999-06-30
JP2848218B2 (ja) 1999-01-20
ES2054678T3 (es) 1994-08-16
FI981807A0 (fi) 1998-08-24
JPH07108860B2 (ja) 1995-11-22
EP0271180B1 (en) 1993-05-26
HU220205B (hu) 2001-11-28
NZ221484A (en) 1991-01-29
FI103410B (fi) 1999-06-30
HK54396A (en) 1996-04-03
IE872210L (en) 1988-02-18
DE3786000T3 (de) 1997-08-21
JPH06220190A (ja) 1994-08-09
WO1988001180A1 (en) 1988-02-25
AU8139191A (en) 1991-10-03
EP0271180B2 (en) 1997-06-18
IL83567A (en) 1992-02-16
WO1988001178A1 (en) 1988-02-25
DK205388D0 (da) 1988-04-14
EP0271180A1 (en) 1988-06-15
NO176306B (no) 1994-12-05
ES2054678T5 (es) 1997-09-16
GR3024215T3 (en) 1997-10-31
AU7715987A (en) 1988-03-03
FI881768A (fi) 1988-04-15
BR8707432A (pt) 1988-11-01
NO881639D0 (no) 1988-04-15
DE3786000T2 (de) 1993-09-02
FI981807A (fi) 1998-08-24
KR970011151B1 (ko) 1997-07-07
DK205388A (da) 1988-06-14
DK174053B1 (da) 2002-05-13
FI105693B (fi) 2000-09-29
HU9303379D0 (en) 1994-03-28
FI881768A0 (fi) 1988-04-15
AU609051B2 (en) 1991-04-26
HU209252B (en) 1994-04-28
JPH0757735B2 (ja) 1995-06-21
BR8707431A (pt) 1988-11-01
BR8707433A (pt) 1988-11-01
JP2771404B2 (ja) 1998-07-02
JPH06219966A (ja) 1994-08-09
DE3786000D1 (de) 1993-07-01
JPH069778A (ja) 1994-01-18
JPS63501876A (ja) 1988-07-28
HUT55245A (en) 1991-05-28
JPH072840B2 (ja) 1995-01-18
JPH0757736B2 (ja) 1995-06-21
NO881639L (no) 1988-06-15
IE61356B1 (en) 1994-11-02
JPS63501878A (ja) 1988-07-28
NO176306C (no) 1995-03-15
ZA876114B (en) 1989-04-26
MY102878A (en) 1993-03-31
IL83567A0 (en) 1988-01-31
KR880701564A (ko) 1988-11-03
WO1988001179A1 (en) 1988-02-25
JPS63502350A (ja) 1988-09-08

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