JP2003505519A - 多座結合を介した多量体画像化剤の標的化 - Google Patents

多座結合を介した多量体画像化剤の標的化

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Publication number
JP2003505519A
JP2003505519A JP2001513442A JP2001513442A JP2003505519A JP 2003505519 A JP2003505519 A JP 2003505519A JP 2001513442 A JP2001513442 A JP 2001513442A JP 2001513442 A JP2001513442 A JP 2001513442A JP 2003505519 A JP2003505519 A JP 2003505519A
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JP
Japan
Prior art keywords
contrast agent
target
iem
scaffold
tbm
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2001513442A
Other languages
English (en)
Japanese (ja)
Other versions
JP2003505519A5 (enExample
Inventor
ランダル ビー． ローファー，
トーマス ジェイ． マックマリー，
ステファン デュマ，
アンドリュー コロヅィー，
ジョン アメディオ，
ピーター キャラバン，
シャオダ シャング，
シュリクマー ナイアー，
Original Assignee
エピックス メディカル， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エピックス メディカル， インコーポレイテッド filed Critical エピックス メディカル， インコーポレイテッド
Publication of JP2003505519A publication Critical patent/JP2003505519A/ja
Publication of JP2003505519A5 publication Critical patent/JP2003505519A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A61K49/128—Linear polymers, e.g. dextran, inulin, PEG comprising multiple complex or complex-forming groups, being either part of the linear polymeric backbone or being pending groups covalently linked to the linear polymeric backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
JP2001513442A 1999-07-29 2000-07-28 多座結合を介した多量体画像化剤の標的化 Pending JP2003505519A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14641499P 1999-07-29 1999-07-29
US16365099P 1999-11-04 1999-11-04
US60/146,414 1999-11-04
US60/163,650 1999-11-04
PCT/US2000/020536 WO2001008712A2 (en) 1999-07-29 2000-07-28 Targeting multimeric imaging agents through multilocus binding

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2002341392A Division JP2003201258A (ja) 1999-07-29 2002-11-25 多座結合を介した多量体画像化剤の標的化

Publications (2)

Publication Number Publication Date
JP2003505519A true JP2003505519A (ja) 2003-02-12
JP2003505519A5 JP2003505519A5 (enExample) 2006-01-05

Family

ID=26843871

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2001513442A Pending JP2003505519A (ja) 1999-07-29 2000-07-28 多座結合を介した多量体画像化剤の標的化
JP2002341392A Pending JP2003201258A (ja) 1999-07-29 2002-11-25 多座結合を介した多量体画像化剤の標的化

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2002341392A Pending JP2003201258A (ja) 1999-07-29 2002-11-25 多座結合を介した多量体画像化剤の標的化

Country Status (20)

Country Link
US (2) US6652835B1 (enExample)
EP (1) EP1210124A2 (enExample)
JP (2) JP2003505519A (enExample)
KR (1) KR20020057946A (enExample)
CN (2) CN1382062A (enExample)
AU (1) AU6386000A (enExample)
BR (1) BR0013171A (enExample)
CA (1) CA2384565A1 (enExample)
CZ (1) CZ2002343A3 (enExample)
EA (1) EA200200220A1 (enExample)
HK (1) HK1048952A1 (enExample)
HU (1) HUP0202635A3 (enExample)
IL (1) IL147854A0 (enExample)
IS (1) IS6241A (enExample)
MX (1) MXPA02001017A (enExample)
NO (1) NO20020474L (enExample)
NZ (1) NZ517017A (enExample)
PL (1) PL353336A1 (enExample)
WO (1) WO2001008712A2 (enExample)
YU (1) YU6502A (enExample)

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Title
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003201258A (ja) * 1999-07-29 2003-07-18 Epix Medical Inc 多座結合を介した多量体画像化剤の標的化

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HK1048952A1 (zh) 2003-04-25
NO20020474L (no) 2002-03-27
WO2001008712A2 (en) 2001-02-08
US6652835B1 (en) 2003-11-25
CN1626246A (zh) 2005-06-15
NO20020474D0 (no) 2002-01-29
HUP0202635A2 (hu) 2002-11-28
CA2384565A1 (en) 2001-02-08
AU6386000A (en) 2001-02-19
HUP0202635A3 (en) 2006-03-28
BR0013171A (pt) 2002-05-28
IL147854A0 (en) 2002-08-14
PL353336A1 (en) 2003-11-17
EP1210124A2 (en) 2002-06-05
YU6502A (sh) 2005-06-10
IS6241A (is) 2002-01-18
EA200200220A1 (ru) 2002-08-29
CZ2002343A3 (cs) 2002-08-14
CN1382062A (zh) 2002-11-27
WO2001008712A3 (en) 2002-03-14
MXPA02001017A (es) 2002-08-12
JP2003201258A (ja) 2003-07-18
US20040005274A1 (en) 2004-01-08
NZ517017A (en) 2004-05-28

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