JP2018523657A5 - - Google Patents
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- Publication number
- JP2018523657A5 JP2018523657A5 JP2018504871A JP2018504871A JP2018523657A5 JP 2018523657 A5 JP2018523657 A5 JP 2018523657A5 JP 2018504871 A JP2018504871 A JP 2018504871A JP 2018504871 A JP2018504871 A JP 2018504871A JP 2018523657 A5 JP2018523657 A5 JP 2018523657A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- compound
- group
- nitroxide
- och
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 30
- 150000001875 compounds Chemical class 0.000 claims 26
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical class ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 13
- 102000013455 Amyloid beta-Peptides Human genes 0.000 claims 4
- 108010090849 Amyloid beta-Peptides Proteins 0.000 claims 4
- 238000001514 detection method Methods 0.000 claims 3
- 238000004435 EPR spectroscopy Methods 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 238000000386 microscopy Methods 0.000 claims 1
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 claims 1
- 238000002600 positron emission tomography Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 0 CC(C)(C=C(C*)C1(C)C)N1[O+] Chemical compound CC(C)(C=C(C*)C1(C)C)N1[O+] 0.000 description 3
- ZRRHQWCIZLOCLS-UHFFFAOYSA-O CC(C)(CC(C1(C)C)C(NCCN(C)C)=O)N1[OH2+] Chemical compound CC(C)(CC(C1(C)C)C(NCCN(C)C)=O)N1[OH2+] ZRRHQWCIZLOCLS-UHFFFAOYSA-O 0.000 description 1
- REIRZSNTXASSGM-UHFFFAOYSA-O CC(CC1(C)C)C(C)(C)N1[OH2+] Chemical compound CC(CC1(C)C)C(C)(C)N1[OH2+] REIRZSNTXASSGM-UHFFFAOYSA-O 0.000 description 1
- HCBNBJLXAYCZLF-UHFFFAOYSA-N CC(CC1(C)C)CC(C)(C)N1O Chemical compound CC(CC1(C)C)CC(C)(C)N1O HCBNBJLXAYCZLF-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562206706P | 2015-08-18 | 2015-08-18 | |
| US62/206,706 | 2015-08-18 | ||
| PCT/US2016/047414 WO2017031239A1 (en) | 2015-08-18 | 2016-08-17 | Nitroxide containing amyloid binding agents for imaging and therapeutic uses |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523657A JP2018523657A (ja) | 2018-08-23 |
| JP2018523657A5 true JP2018523657A5 (enExample) | 2019-09-26 |
| JP7114074B2 JP7114074B2 (ja) | 2022-08-08 |
Family
ID=58051663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018504871A Active JP7114074B2 (ja) | 2015-08-18 | 2016-08-17 | 画像化のためのニトロキシドを含むアミロイド結合剤およびその治療的使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US10478513B2 (enExample) |
| EP (1) | EP3337475B1 (enExample) |
| JP (1) | JP7114074B2 (enExample) |
| KR (1) | KR20180052611A (enExample) |
| CN (1) | CN107949383B (enExample) |
| AU (2) | AU2016308189B2 (enExample) |
| CA (1) | CA2994178C (enExample) |
| WO (1) | WO2017031239A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7114074B2 (ja) * | 2015-08-18 | 2022-08-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 画像化のためのニトロキシドを含むアミロイド結合剤およびその治療的使用 |
| CN108600272B (zh) | 2018-05-10 | 2020-08-04 | 阿里巴巴集团控股有限公司 | 一种区块链数据处理方法、装置、处理设备及系统 |
| CN110152009A (zh) * | 2019-05-09 | 2019-08-23 | 中国科学院兰州化学物理研究所 | 一种多取代白藜芦醇自旋标记衍生物及其制备方法和应用 |
| KR102344676B1 (ko) * | 2020-02-12 | 2021-12-30 | 한국과학기술연구원 | 타우 응집체에 선택적으로 결합하는 근적외선 형광 탐침자로서 유효한 신규 화합물 및 이의 제조방법 |
| PL441664A1 (pl) * | 2022-07-07 | 2024-01-08 | Uniwersytet Warszawski | Nitroksylowa pochodna polifenolu, sposoby jej wytwarzania oraz jej zastosowanie |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1208697A (en) * | 1995-12-28 | 1997-07-28 | Daiichi Radioisotope Laboratories, Ltd. | Diagnostic drugs |
| DE60113407T2 (de) | 2000-05-04 | 2006-06-29 | Warner-Lambert Co. Llc | Verfahren zur hemmung von amyloidprotein aggregation und zur diagnostischen nachweis von amyloidablagerung unter verwendung von aminoindanderivaten |
| JP2004067659A (ja) | 2002-06-12 | 2004-03-04 | Bf Kenkyusho:Kk | タウ蛋白蓄積性疾患の診断プローブとしてのベンゾイミダゾール環含有化合物 |
| CA2830939C (en) | 2004-07-02 | 2017-02-28 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Use of thioflavin radiolabelled derivatives in amyloid imaging for identifying patients prodromal to a disease associated with amyloid deposition |
| WO2007047204A1 (en) | 2005-10-11 | 2007-04-26 | University Of Pittsburgh | Isotopically-labeled benzofuran compounds as imagingagents foramyloidogenic proteins |
| US8022075B2 (en) | 2005-11-30 | 2011-09-20 | Fujifilm Ri Pharma Co., Ltd. | Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition |
| NZ570887A (en) | 2006-03-30 | 2011-05-27 | Univ Pennsylvania | Styrylpyridine derivatives and their use for binding and imaging amyloid plaques |
| TW200813035A (en) | 2006-06-19 | 2008-03-16 | Astrazeneca Ab | Novel heteroaryl substituted benzoxazoles |
| US8168800B2 (en) | 2007-11-02 | 2012-05-01 | The Regents Of The University Of California | Aβ-binding small molecules |
| SI2338059T1 (sl) | 2008-09-23 | 2015-08-31 | Wista Laboratories Ltd. | Ligandi za agregirane molekule tau |
| JP5825608B2 (ja) * | 2010-08-06 | 2015-12-02 | 国立大学法人京都大学 | ピリジルベンゾフラン誘導体 |
| CA2862076C (en) | 2012-01-23 | 2020-04-21 | Sage Therapeutics, Inc. | Neuroactive steroid formulations and methods of treating cns disorders |
| JP2016501876A (ja) | 2012-11-30 | 2016-01-21 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ステロイドの抗痙攣活性 |
| JP7114074B2 (ja) * | 2015-08-18 | 2022-08-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 画像化のためのニトロキシドを含むアミロイド結合剤およびその治療的使用 |
-
2016
- 2016-08-17 JP JP2018504871A patent/JP7114074B2/ja active Active
- 2016-08-17 US US15/748,556 patent/US10478513B2/en active Active
- 2016-08-17 WO PCT/US2016/047414 patent/WO2017031239A1/en not_active Ceased
- 2016-08-17 AU AU2016308189A patent/AU2016308189B2/en active Active
- 2016-08-17 CA CA2994178A patent/CA2994178C/en active Active
- 2016-08-17 KR KR1020187004878A patent/KR20180052611A/ko not_active Ceased
- 2016-08-17 EP EP16837776.0A patent/EP3337475B1/en active Active
- 2016-08-17 CN CN201680048440.1A patent/CN107949383B/zh active Active
-
2019
- 2019-10-07 US US16/595,178 patent/US10881748B2/en active Active
-
2021
- 2021-06-09 AU AU2021203794A patent/AU2021203794A1/en not_active Abandoned
- 2021-07-30 US US17/389,674 patent/US12064488B2/en active Active
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