JP2013507345A5 - - Google Patents
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- Publication number
- JP2013507345A5 JP2013507345A5 JP2012532624A JP2012532624A JP2013507345A5 JP 2013507345 A5 JP2013507345 A5 JP 2013507345A5 JP 2012532624 A JP2012532624 A JP 2012532624A JP 2012532624 A JP2012532624 A JP 2012532624A JP 2013507345 A5 JP2013507345 A5 JP 2013507345A5
- Authority
- JP
- Japan
- Prior art keywords
- pet
- compound according
- radiofluorinated
- gaba
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 150000001875 compounds Chemical class 0.000 claims 14
- 238000000034 method Methods 0.000 claims 12
- 238000002600 positron emission tomography Methods 0.000 claims 7
- 239000002243 precursor Substances 0.000 claims 6
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 5
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 230000002285 radioactive effect Effects 0.000 claims 3
- 238000002405 diagnostic procedure Methods 0.000 claims 2
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229940121896 radiopharmaceutical Drugs 0.000 claims 2
- 239000012217 radiopharmaceutical Substances 0.000 claims 2
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 238000012879 PET imaging Methods 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0917612.4A GB0917612D0 (en) | 2009-10-08 | 2009-10-08 | In vivo imaging agents |
| GB0917612.4 | 2009-10-08 | ||
| US25089009P | 2009-10-13 | 2009-10-13 | |
| US61/250,890 | 2009-10-13 | ||
| PCT/EP2010/065126 WO2011042550A1 (en) | 2009-10-08 | 2010-10-08 | [18 f] - labelled analogues of flumazenil as in vivo imaging agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013507345A JP2013507345A (ja) | 2013-03-04 |
| JP2013507345A5 true JP2013507345A5 (enExample) | 2013-10-17 |
Family
ID=41402711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012532624A Withdrawn JP2013507345A (ja) | 2009-10-08 | 2010-10-08 | インビボイメージング剤としてのフルマゼニルの［１８ｆ］標識類似体 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120189547A1 (enExample) |
| EP (1) | EP2486043A1 (enExample) |
| JP (1) | JP2013507345A (enExample) |
| CN (1) | CN102574859A (enExample) |
| GB (1) | GB0917612D0 (enExample) |
| WO (1) | WO2011042550A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101441406B1 (ko) * | 2011-05-25 | 2014-11-04 | 주식회사 바이오이미징코리아 | 디아릴이오도늄 염 전구체를 이용한 플로오린-18이 표지된 플루마제닐의 제조 방법 |
| GB201117785D0 (en) * | 2011-10-14 | 2011-11-30 | Ge Healthcare Ltd | Improved radiosynthesis method |
| GB201117786D0 (en) * | 2011-10-14 | 2011-11-30 | Ge Healthcare Ltd | Eluent vial |
| WO2014047413A1 (en) * | 2012-09-21 | 2014-03-27 | Uwm Research Foundation, Inc. | Novel gabaa agonists and methods of using to control airway hyperresponsiveness and inflammation in asthma |
| WO2023213757A1 (en) * | 2022-05-03 | 2023-11-09 | F. Hoffmann-La Roche Ag | Pet tracers for visualizing gabaa gamma1 receptors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1143728A (en) * | 1979-10-04 | 1983-03-29 | Max Gerecke | Imidazodiazepine derivatives |
| AU587802B2 (en) * | 1985-03-08 | 1989-08-31 | Ferrosan A/S | Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds |
| GB0524851D0 (en) * | 2005-12-06 | 2006-01-11 | Ge Healthcare Ltd | Radiolabelling method using polymers |
-
2009
- 2009-10-08 GB GBGB0917612.4A patent/GB0917612D0/en not_active Ceased
-
2010
- 2010-10-08 WO PCT/EP2010/065126 patent/WO2011042550A1/en not_active Ceased
- 2010-10-08 US US13/394,639 patent/US20120189547A1/en not_active Abandoned
- 2010-10-08 EP EP10771691A patent/EP2486043A1/en not_active Withdrawn
- 2010-10-08 CN CN2010800457017A patent/CN102574859A/zh active Pending
- 2010-10-08 JP JP2012532624A patent/JP2013507345A/ja not_active Withdrawn
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