JP2012523388A5 - - Google Patents
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- Publication number
- JP2012523388A5 JP2012523388A5 JP2012503993A JP2012503993A JP2012523388A5 JP 2012523388 A5 JP2012523388 A5 JP 2012523388A5 JP 2012503993 A JP2012503993 A JP 2012503993A JP 2012503993 A JP2012503993 A JP 2012503993A JP 2012523388 A5 JP2012523388 A5 JP 2012523388A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo imaging
- imaging agent
- agent according
- formula
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000011503 in vivo imaging Methods 0.000 claims 19
- 239000012216 imaging agent Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 7
- 239000002243 precursor Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 230000002285 radioactive effect Effects 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 2
- 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Chemical group 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 239000012217 radiopharmaceutical Substances 0.000 claims 1
- 229940121896 radiopharmaceutical Drugs 0.000 claims 1
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16789309P | 2009-04-09 | 2009-04-09 | |
| GB0906274.6 | 2009-04-09 | ||
| GBGB0906274.6A GB0906274D0 (en) | 2009-04-09 | 2009-04-09 | Imaging the central nervous system |
| US61/167,893 | 2009-04-09 | ||
| PCT/EP2010/054517 WO2010115881A1 (en) | 2009-04-09 | 2010-04-06 | Imaging the central nervous system with purinergic p2x7 receptor binding agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012523388A JP2012523388A (ja) | 2012-10-04 |
| JP2012523388A5 true JP2012523388A5 (enExample) | 2013-05-16 |
Family
ID=40750455
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012503993A Withdrawn JP2012523388A (ja) | 2009-04-09 | 2010-04-06 | プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20120034165A1 (enExample) |
| EP (1) | EP2416808A1 (enExample) |
| JP (1) | JP2012523388A (enExample) |
| CN (1) | CN102834120A (enExample) |
| GB (1) | GB0906274D0 (enExample) |
| WO (1) | WO2010115881A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2474523B1 (en) | 2006-12-26 | 2020-04-08 | Lantheus Medical Imaging, Inc. | Ligands for imaging cardiac innervation |
| MX343721B (es) | 2010-05-11 | 2016-11-17 | Lantheus Medical Imaging Inc | Composiciones, metodos y sistemas para la sintesis y el uso de agentes trazadores. |
| WO2012065248A1 (en) * | 2010-11-16 | 2012-05-24 | Kay Denis G | Method for increasing neprilysin expression and activity |
| US9550000B2 (en) | 2011-09-09 | 2017-01-24 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101304981A (zh) * | 2005-11-07 | 2008-11-12 | 艾博特公司 | P2x7受体拮抗剂及使用方法 |
| CA2645652A1 (en) | 2006-03-16 | 2007-09-27 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| TWI464148B (zh) | 2006-03-16 | 2014-12-11 | Evotec Us Inc | 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途 |
| US20090149524A1 (en) | 2006-06-06 | 2009-06-11 | Paul John Beswick | N-(Phenylmethyl)-2-(1H-Pyrazol-4-yl) Acetamide Derivatives as P2X7 Antagonists for the Treatment of Pain, Inflammation and Neurodegeneration |
| WO2008064432A1 (en) | 2006-12-01 | 2008-06-05 | The University Of Sydney | Polycyclic molecular compounds |
| GB0803729D0 (en) * | 2008-02-29 | 2008-04-09 | Ge Healthcare Ltd | Imaging the central nervous system |
-
2009
- 2009-04-09 GB GBGB0906274.6A patent/GB0906274D0/en not_active Ceased
-
2010
- 2010-04-06 US US13/263,093 patent/US20120034165A1/en not_active Abandoned
- 2010-04-06 EP EP10714607A patent/EP2416808A1/en not_active Ceased
- 2010-04-06 CN CN2010800164529A patent/CN102834120A/zh active Pending
- 2010-04-06 JP JP2012503993A patent/JP2012523388A/ja not_active Withdrawn
- 2010-04-06 WO PCT/EP2010/054517 patent/WO2010115881A1/en not_active Ceased
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