JP2011513277A5 - - Google Patents

Info

Publication number

JP2011513277A5

JP2011513277A5 JP2010548105A JP2010548105A JP2011513277A5 JP 2011513277 A5 JP2011513277 A5 JP 2011513277A5 JP 2010548105 A JP2010548105 A JP 2010548105A JP 2010548105 A JP2010548105 A JP 2010548105A JP 2011513277 A5 JP2011513277 A5 JP 2011513277A5

Authority

JP

Japan

Prior art keywords

vivo imaging

subject

imaging agent

formula

cns

Prior art date

2009-02-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 238000011503 in vivo imaging Methods 0.000 claims 17
• 239000012216 imaging agent Substances 0.000 claims 11
• 238000000034 method Methods 0.000 claims 10
• 210000003169 central nervous system Anatomy 0.000 claims 7
• 229910052739 hydrogen Inorganic materials 0.000 claims 5
• 239000001257 hydrogen Substances 0.000 claims 5
• 239000002243 precursor Substances 0.000 claims 5
• 150000001875 compounds Chemical class 0.000 claims 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
• 150000002431 hydrogen Chemical class 0.000 claims 3
• 229910052757 nitrogen Inorganic materials 0.000 claims 3
• 206010061218 Inflammation Diseases 0.000 claims 2
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
• 125000000217 alkyl group Chemical group 0.000 claims 2
• 125000003118 aryl group Chemical group 0.000 claims 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
• 125000005843 halogen group Chemical group 0.000 claims 2
• 125000005842 heteroatom Chemical group 0.000 claims 2
• 125000000623 heterocyclic group Chemical group 0.000 claims 2
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 239000001301 oxygen Substances 0.000 claims 2
• 230000002285 radioactive effect Effects 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 239000011593 sulfur Substances 0.000 claims 2
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
• 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 230000001594 aberrant effect Effects 0.000 claims 1
• 230000002159 abnormal effect Effects 0.000 claims 1
• 125000002252 acyl group Chemical group 0.000 claims 1
• 125000003545 alkoxy group Chemical group 0.000 claims 1
• 238000002405 diagnostic procedure Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000004428 fluoroalkoxy group Chemical group 0.000 claims 1
• 125000003106 haloaryl group Chemical group 0.000 claims 1
• 229910052736 halogen Inorganic materials 0.000 claims 1
• 150000002367 halogens Chemical class 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 238000003384 imaging method Methods 0.000 claims 1
• 238000005342 ion exchange Methods 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229910052755 nonmetal Inorganic materials 0.000 claims 1
• 125000004043 oxo group Chemical group O=* 0.000 claims 1
• 230000001575 pathological effect Effects 0.000 claims 1
• 239000012217 radiopharmaceutical Substances 0.000 claims 1
• 229940121896 radiopharmaceutical Drugs 0.000 claims 1
• 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• 230000002194 synthesizing effect Effects 0.000 claims 1