JP2011513277A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011513277A5 JP2011513277A5 JP2010548105A JP2010548105A JP2011513277A5 JP 2011513277 A5 JP2011513277 A5 JP 2011513277A5 JP 2010548105 A JP2010548105 A JP 2010548105A JP 2010548105 A JP2010548105 A JP 2010548105A JP 2011513277 A5 JP2011513277 A5 JP 2011513277A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo imaging
- subject
- imaging agent
- formula
- cns
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000011503 in vivo imaging Methods 0.000 claims 17
- 239000012216 imaging agent Substances 0.000 claims 11
- 238000000034 method Methods 0.000 claims 10
- 210000003169 central nervous system Anatomy 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 239000002243 precursor Substances 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 2
- 125000002733 (C1-C6) fluoroalkyl group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 230000001594 aberrant effect Effects 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 238000002405 diagnostic procedure Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004428 fluoroalkoxy group Chemical group 0.000 claims 1
- 125000003106 haloaryl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000003384 imaging method Methods 0.000 claims 1
- 238000005342 ion exchange Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000001575 pathological effect Effects 0.000 claims 1
- 239000012217 radiopharmaceutical Substances 0.000 claims 1
- 229940121896 radiopharmaceutical Drugs 0.000 claims 1
- 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 230000002194 synthesizing effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3244208P | 2008-02-29 | 2008-02-29 | |
| GBGB0803729.3A GB0803729D0 (en) | 2008-02-29 | 2008-02-29 | Imaging the central nervous system |
| PCT/EP2009/052280 WO2009106564A2 (en) | 2008-02-29 | 2009-02-26 | Imaging the central nervous system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011513277A JP2011513277A (ja) | 2011-04-28 |
| JP2011513277A5 true JP2011513277A5 (enExample) | 2012-03-22 |
Family
ID=39315680
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010548105A Pending JP2011513277A (ja) | 2008-02-29 | 2009-02-26 | 中枢神経系のイメージング |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110027178A1 (enExample) |
| EP (1) | EP2247316B1 (enExample) |
| JP (1) | JP2011513277A (enExample) |
| CN (3) | CN102600487B (enExample) |
| GB (1) | GB0803729D0 (enExample) |
| WO (1) | WO2009106564A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0906274D0 (en) * | 2009-04-09 | 2009-05-20 | Ge Healthcare Ltd | Imaging the central nervous system |
| GB0917611D0 (en) * | 2009-10-08 | 2009-11-25 | Ge Healthcare Ltd | Automated radiosynthesis |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9704546D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Pharma Prod | Novel compounds |
| JP2005537226A (ja) * | 2002-04-16 | 2005-12-08 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 診断薬としての標識オキサジノカルバゾール |
| EP1556142A4 (en) * | 2002-10-24 | 2006-11-08 | Merck & Co Inc | ALKYN DERIVATIVES AS TRACERS FOR THE METABOTROPE GLUTAMATE RECEPTOR BINDING |
| PA8591801A1 (es) * | 2002-12-31 | 2004-07-26 | Pfizer Prod Inc | Inhibidores benzamidicos del receptor p2x7. |
| AU2004294989B2 (en) * | 2003-12-01 | 2009-03-19 | Ignasi Carrio | Novel differential imaging method |
| JP2009539795A (ja) * | 2006-06-06 | 2009-11-19 | グラクソ グループ リミテッド | 疼痛、炎症および神経変性の治療のためのｐ２ｘ７アンタゴニストとしてのｎ−（フェニルメチル）−２−（１ｈ−ピラゾール−４−イル）アセトアミド誘導体 |
| KR101554366B1 (ko) * | 2006-06-21 | 2015-09-18 | 지이 헬쓰케어 리미티드 | 방사성 의약품 |
| US7718693B2 (en) * | 2006-07-06 | 2010-05-18 | Glaxo Group Limited | Receptor antagonists and their methods of use |
| WO2008064432A1 (en) * | 2006-12-01 | 2008-06-05 | The University Of Sydney | Polycyclic molecular compounds |
-
2008
- 2008-02-29 GB GBGB0803729.3A patent/GB0803729D0/en not_active Ceased
-
2009
- 2009-02-26 WO PCT/EP2009/052280 patent/WO2009106564A2/en not_active Ceased
- 2009-02-26 CN CN2012100777139A patent/CN102600487B/zh not_active Expired - Fee Related
- 2009-02-26 EP EP09715070.0A patent/EP2247316B1/en not_active Not-in-force
- 2009-02-26 JP JP2010548105A patent/JP2011513277A/ja active Pending
- 2009-02-26 CN CN2009801067913A patent/CN101970017B/zh not_active Expired - Fee Related
- 2009-02-26 US US12/867,914 patent/US20110027178A1/en not_active Abandoned
- 2009-02-26 CN CN2012100777571A patent/CN102600488B/zh not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2021095407A (ja) | Ｐｓｍａ結合剤及びその使用 | |
| KR20210154191A (ko) | 저산소증 유도성 인자-2(알파) 억제제로서의 테트라하이드로-1h-사이클로펜타[cd]인덴 유도체 | |
| US20220056052A1 (en) | Quinazoline derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors | |
| JP2012521973A5 (enExample) | ||
| TW202204314A (zh) | 低氧誘導因子—２（α）抑制劑及其在治療疾病之用途 | |
| CN114040915A (zh) | 作为外核苷酸焦磷酸酶磷酸二酯酶1抑制剂的双环杂芳基衍生物 | |
| JPWO2015199205A1 (ja) | ２−（３−ピリジニル）−１ｈ−ベンゾイミダゾール誘導体化合物、及び、これを含む医薬 | |
| ES2907130T3 (es) | Darapladib radiomarcado, análogos del mismo y su uso como compuestos para la obtención de imágenes | |
| JP2013523621A5 (enExample) | ||
| JP2012504581A5 (enExample) | ||
| JP2011513277A5 (enExample) | ||
| JP2012523388A5 (enExample) | ||
| US8592449B1 (en) | Radiolabelled phenylimidazole-based ligands | |
| KR102063498B1 (ko) | 불포화 탄화수소기를 갖는 알코올 용매를 이용한 플루오로 화합물의 제조방법 | |
| JP2013507345A5 (enExample) | ||
| JP2012520855A5 (enExample) | ||
| JP6190240B2 (ja) | 癌に対する治療効果の診断剤 | |
| US20120034165A1 (en) | Imaging the central nervous system with purinergic p2x7 receptor binding agents | |
| EP2450354B1 (en) | Labeling compound for pet | |
| JP2016530337A5 (enExample) | ||
| JP2013514319A5 (enExample) | ||
| RU2855873C2 (ru) | Бициклические гетероарильные производные как ингибиторы эктонуклеотид пирофосфатазы фосфодиэстеразы 1 | |
| JP7688339B2 (ja) | 新規化合物、およびその利用 | |
| TW202015743A (zh) | 心臟病的非侵入性影像診斷劑 | |
| WO2014126071A1 (ja) | 芳香族アミノ酸誘導体およびそれを用いるｐｅｔプローブ |