CN102600487B - 中枢神经系统的显像 - Google Patents

中枢神经系统的显像 Download PDF

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Publication number
CN102600487B
CN102600487B CN2012100777139A CN201210077713A CN102600487B CN 102600487 B CN102600487 B CN 102600487B CN 2012100777139 A CN2012100777139 A CN 2012100777139A CN 201210077713 A CN201210077713 A CN 201210077713A CN 102600487 B CN102600487 B CN 102600487B
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CN
China
Prior art keywords
formula
compound
developer
vivo imaging
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2012100777139A
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English (en)
Chinese (zh)
Other versions
CN102600487A (zh
Inventor
P·A·琼斯
I·威尔逊
V·莫里森-艾夫森
C·琼斯
J·伍德克拉夫特
A·杰克逊
D·怀恩
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN102600487A publication Critical patent/CN102600487A/zh
Application granted granted Critical
Publication of CN102600487B publication Critical patent/CN102600487B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN2012100777139A 2008-02-29 2009-02-26 中枢神经系统的显像 Expired - Fee Related CN102600487B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US3244208P 2008-02-29 2008-02-29
GBGB0803729.3A GB0803729D0 (en) 2008-02-29 2008-02-29 Imaging the central nervous system
US61/032,442 2008-02-29
US61/032442 2008-02-29
GB0803729.3 2008-02-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2009801067913A Division CN101970017B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Publications (2)

Publication Number Publication Date
CN102600487A CN102600487A (zh) 2012-07-25
CN102600487B true CN102600487B (zh) 2013-11-20

Family

ID=39315680

Family Applications (3)

Application Number Title Priority Date Filing Date
CN2012100777139A Expired - Fee Related CN102600487B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2009801067913A Expired - Fee Related CN101970017B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2012100777571A Expired - Fee Related CN102600488B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN2009801067913A Expired - Fee Related CN101970017B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像
CN2012100777571A Expired - Fee Related CN102600488B (zh) 2008-02-29 2009-02-26 中枢神经系统的显像

Country Status (6)

Country Link
US (1) US20110027178A1 (enExample)
EP (1) EP2247316B1 (enExample)
JP (1) JP2011513277A (enExample)
CN (3) CN102600487B (enExample)
GB (1) GB0803729D0 (enExample)
WO (1) WO2009106564A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0906274D0 (en) * 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
GB0917611D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd Automated radiosynthesis

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9704546D0 (sv) * 1997-12-05 1997-12-05 Astra Pharma Prod Novel compounds
EP1495031A1 (en) * 2002-04-16 2005-01-12 Pharmacia & Upjohn Company LLC Labeled oxazinocarbazoles as diagnostic agents
JP2006513996A (ja) * 2002-10-24 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
CA2549141C (en) * 2003-12-01 2012-10-23 Medi-Physics, Inc. Novel differential imaging method
WO2007148088A2 (en) * 2006-06-21 2007-12-27 Ge Healthcare Limited Radiopharmaceutical products
AU2007271182B2 (en) * 2006-07-06 2012-03-15 Glaxo Group Limited Substituted N-phenylmethyl -5-oxo-proline-2-amides as P2X7-receptor antagonists and their methods of use
WO2008064432A1 (en) * 2006-12-01 2008-06-05 The University Of Sydney Polycyclic molecular compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
《Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373》;Stokes L, et. al.;《Br J Pharmacol.》;20061209;第149卷(第7期);880-7 *
《Negative and positive allosteric modulators of the P2X(7) receptor》;Michel AD, Chambers LJ, Walter DS.;《Br J Pharmacol.》;20071210;第153卷(第4期);737-750 *
《Structure-activity relationship studies on a series of novel,substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists 》;Nelson DW, et. al.;《J Med Chem.》;20060101;第49卷(第12期);3659-66 *
Michel AD, Chambers LJ, Walter DS..《Negative and positive allosteric modulators of the P2X(7) receptor》.《Br J Pharmacol.》.2007,第153卷(第4期),737-750.
Nelson DW, et. al..《Structure-activity relationship studies on a series of novel,substituted 1-benzyl-5-phenyltetrazole P2X7 antagonists 》.《J Med Chem.》.2006,第49卷(第12期),3659-66.
Stokes L, et. al..《Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373》.《Br J Pharmacol.》.2006,第149卷(第7期),880-7.

Also Published As

Publication number Publication date
JP2011513277A (ja) 2011-04-28
CN102600488A (zh) 2012-07-25
CN102600488B (zh) 2013-11-20
WO2009106564A2 (en) 2009-09-03
CN102600487A (zh) 2012-07-25
CN101970017B (zh) 2012-05-23
US20110027178A1 (en) 2011-02-03
EP2247316B1 (en) 2013-11-06
GB0803729D0 (en) 2008-04-09
EP2247316A2 (en) 2010-11-10
WO2009106564A3 (en) 2010-03-25
CN101970017A (zh) 2011-02-09

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20131120

Termination date: 20140226