JP2011513277A - 中枢神経系のイメージング - Google Patents

中枢神経系のイメージング Download PDF

Info

Publication number
JP2011513277A
JP2011513277A JP2010548105A JP2010548105A JP2011513277A JP 2011513277 A JP2011513277 A JP 2011513277A JP 2010548105 A JP2010548105 A JP 2010548105A JP 2010548105 A JP2010548105 A JP 2010548105A JP 2011513277 A JP2011513277 A JP 2011513277A
Authority
JP
Japan
Prior art keywords
vivo imaging
formula
imaging agent
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010548105A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011513277A5 (enExample
Inventor
ジョーンズ，ポール・アレキサンダー
ウィルソン，イアン
モリソン−イヴソン，ヴェロニーク
ジョーンズ，クレア
ウッドクラフト，ジョン
ジャクソン，アレックス
ウィン，ダンカン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of JP2011513277A publication Critical patent/JP2011513277A/ja
Publication of JP2011513277A5 publication Critical patent/JP2011513277A5/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2010548105A 2008-02-29 2009-02-26 中枢神経系のイメージング Pending JP2011513277A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3244208P 2008-02-29 2008-02-29
GBGB0803729.3A GB0803729D0 (en) 2008-02-29 2008-02-29 Imaging the central nervous system
PCT/EP2009/052280 WO2009106564A2 (en) 2008-02-29 2009-02-26 Imaging the central nervous system

Publications (2)

Publication Number Publication Date
JP2011513277A true JP2011513277A (ja) 2011-04-28
JP2011513277A5 JP2011513277A5 (enExample) 2012-03-22

Family

ID=39315680

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010548105A Pending JP2011513277A (ja) 2008-02-29 2009-02-26 中枢神経系のイメージング

Country Status (6)

Country Link
US (1) US20110027178A1 (enExample)
EP (1) EP2247316B1 (enExample)
JP (1) JP2011513277A (enExample)
CN (3) CN102600488B (enExample)
GB (1) GB0803729D0 (enExample)
WO (1) WO2009106564A2 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0906274D0 (en) * 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
GB0917611D0 (en) * 2009-10-08 2009-11-25 Ge Healthcare Ltd Automated radiosynthesis

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525406A (ja) * 1997-12-05 2001-12-11 アストラゼネカ ユーケイ リミテッド 新規な化合物
JP2005537226A (ja) * 2002-04-16 2005-12-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 診断薬としての標識オキサジノカルバゾール
JP2006513996A (ja) * 2002-10-24 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
JP2007517773A (ja) * 2003-12-01 2007-07-05 メディ−フィジックス・インコーポレイテッド 新規示差画像形成法
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration
WO2007148088A2 (en) * 2006-06-21 2007-12-27 Ge Healthcare Limited Radiopharmaceutical products

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PA8591801A1 (es) * 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
CA2655675A1 (en) * 2006-07-06 2008-01-10 Glaxo Group Limited Substituted n-phenylmethyl -5-oxo-proline-2-amides as p2x7-receptor antagonists and their methods of use
WO2008064432A1 (en) * 2006-12-01 2008-06-05 The University Of Sydney Polycyclic molecular compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001525406A (ja) * 1997-12-05 2001-12-11 アストラゼネカ ユーケイ リミテッド 新規な化合物
JP2005537226A (ja) * 2002-04-16 2005-12-08 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 診断薬としての標識オキサジノカルバゾール
JP2006513996A (ja) * 2002-10-24 2006-04-27 メルク　エンド　カムパニー　インコーポレーテッド 代謝調節型グルタミン酸受容体結合用トレーサーとしてのアルキン誘導体
JP2007517773A (ja) * 2003-12-01 2007-07-05 メディ−フィジックス・インコーポレイテッド 新規示差画像形成法
WO2007141267A1 (en) * 2006-06-06 2007-12-13 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration
WO2007148088A2 (en) * 2006-06-21 2007-12-27 Ge Healthcare Limited Radiopharmaceutical products

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013037987; ＳＴＯＫＥＳ，Ｌ．　ｅｔ　ａｌ: 'Ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ　ｏｆ　ａ　ｓｅｌｅｃｔｉｖｅ　ａｎｄ　ｐｏｔｅｎｔ　ａｎｔａｇｏｎｉｓｔ　ｏｆ　ｈｕｍａｎ　Ｐ２Ｘ（７）　ｒｅｃｅｐｔｏｒｓ，　ＡＺ１１６４５３７３' Ｂｒ　Ｊ　Ｐｈａｒｍａｃｏｌ Ｖｏｌ．１４９，　Ｎｏ．７, 2006, ｐ．８８０-７ *
JPN6013037989; ＡＬＣＡＲＡＺ，Ｌ．　ｅｔ　ａｌ: 'Ｎｏｖｅｌ　Ｐ２Ｘ７　ｒｅｃｅｐｔｏｒ　ａｎｔａｇｏｎｉｓｔｓ' Ｂｉｏｏｒｇ　Ｍｅｄ　Ｃｈｅｍ　Ｌｅｔｔ Ｖｏｌ．１３，　Ｎｏ．２２, 2003, ｐ．４０４３-６ *

Also Published As

Publication number Publication date
CN102600487A (zh) 2012-07-25
US20110027178A1 (en) 2011-02-03
CN101970017B (zh) 2012-05-23
EP2247316A2 (en) 2010-11-10
CN102600488B (zh) 2013-11-20
CN102600487B (zh) 2013-11-20
CN102600488A (zh) 2012-07-25
EP2247316B1 (en) 2013-11-06
WO2009106564A3 (en) 2010-03-25
WO2009106564A2 (en) 2009-09-03
GB0803729D0 (en) 2008-04-09
CN101970017A (zh) 2011-02-09

Similar Documents

Publication Publication Date Title
KR20110074988A (ko) 영상화 및 방사선요법을 위한 방법
JP2010513441A (ja) ＩｎＶｉｖｏ造影剤
JP2009515940A (ja) 末梢ベンゾジアゼピンレセプター（ｐｂｒ）親和性を有するインビボイメージング剤としての四環式インドール誘導体
US11844846B2 (en) Styrylbenzothiazole derivatives and uses in imaging methods
RU2512288C2 (ru) Производные индола, подходящие для визуализации нейровоспаления
JP5322180B2 (ja) フッ素およびヒドロキシ基で置換されたアルコキシ基を有するｐｅｔプローブ
US20120034165A1 (en) Imaging the central nervous system with purinergic p2x7 receptor binding agents
JP5787873B2 (ja) インビボイメージング用の放射性標識ピリジニル誘導体
EP2247316B1 (en) Imaging the central nervous system
JP2013507345A (ja) インビボイメージング剤としてのフルマゼニルの［１８ｆ］標識類似体
US9186424B2 (en) Aryloxyanilide imaging agents
WO2014122228A1 (en) Labelled compounds that bind to alpha-v-beta-3 integrin
JP2010529173A (ja) 神経活性の測定
JP2021102593A (ja) タウを画像化する新規化合物
JP2016513083A (ja) 放射標識された化合物
EP2377852A1 (en) Labelled huprine derivatives and their use in medical imaging

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120201

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120201

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20130122

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20130806

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140225