JP2012520855A5 - - Google Patents

Info

Publication number

JP2012520855A5

JP2012520855A5 JP2012500269A JP2012500269A JP2012520855A5 JP 2012520855 A5 JP2012520855 A5 JP 2012520855A5 JP 2012500269 A JP2012500269 A JP 2012500269A JP 2012500269 A JP2012500269 A JP 2012500269A JP 2012520855 A5 JP2012520855 A5 JP 2012520855A5

Authority

JP

Japan

Prior art keywords

vivo

contrast agent

vivo imaging

pbr

subject

Prior art date

2010-03-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000000034 method Methods 0.000 claims 13
• 239000002872 contrast media Substances 0.000 claims 10
• 238000001727 in vivo Methods 0.000 claims 10
• 238000011503 in vivo imaging Methods 0.000 claims 10
• 239000002243 precursor Substances 0.000 claims 8
• 239000012216 imaging agent Substances 0.000 claims 7
• 229910052739 hydrogen Inorganic materials 0.000 claims 5
• 150000001875 compounds Chemical class 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• 239000000126 substance Substances 0.000 claims 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• 125000003545 alkoxy group Chemical group 0.000 claims 2
• 125000004428 fluoroalkoxy group Chemical group 0.000 claims 2
• 125000003709 fluoroalkyl group Chemical group 0.000 claims 2
• 229910052736 halogen Inorganic materials 0.000 claims 2
• 150000002367 halogens Chemical class 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
• 125000006239 protecting group Chemical group 0.000 claims 2
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
• 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 claims 1
• XNRDLSNSMTUXBV-UHFFFAOYSA-N 2-fluoroethyl 4-methylbenzenesulfonate Chemical compound CC1=CC=C(S(=O)(=O)OCCF)C=C1 XNRDLSNSMTUXBV-UHFFFAOYSA-N 0.000 claims 1
• KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 125000004429 atom Chemical group 0.000 claims 1
• 229910052794 bromium Inorganic materials 0.000 claims 1
• 229910052801 chlorine Inorganic materials 0.000 claims 1
• 238000002405 diagnostic procedure Methods 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
• 229910052740 iodine Inorganic materials 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 230000002285 radioactive effect Effects 0.000 claims 1
• 239000012217 radiopharmaceutical Substances 0.000 claims 1
• 229940121896 radiopharmaceutical Drugs 0.000 claims 1
• 230000002799 radiopharmaceutical effect Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 239000012453 solvate Substances 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 238000011269 treatment regimen Methods 0.000 claims 1
• ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1