JP2013047277A5 - - Google Patents
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- JP2013047277A5 JP2013047277A5 JP2012263291A JP2012263291A JP2013047277A5 JP 2013047277 A5 JP2013047277 A5 JP 2013047277A5 JP 2012263291 A JP2012263291 A JP 2012263291A JP 2012263291 A JP2012263291 A JP 2012263291A JP 2013047277 A5 JP2013047277 A5 JP 2013047277A5
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- Prior art keywords
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- 150000001875 compounds Chemical class 0.000 claims 16
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 12
- 238000004519 manufacturing process Methods 0.000 claims 10
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 6
- 238000003384 imaging method Methods 0.000 claims 6
- -1 p-toluenesulfonyl Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 3
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 3
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical group CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 2
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical group [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 230000002107 myocardial effect Effects 0.000 claims 2
- AUONHKJOIZSQGR-UHFFFAOYSA-N oxophosphane Chemical compound P=O AUONHKJOIZSQGR-UHFFFAOYSA-N 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 230000010412 perfusion Effects 0.000 claims 2
- 229910052710 silicon Inorganic materials 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-M toluenesulfonate group Chemical group C=1(C(=CC=CC1)S(=O)(=O)[O-])C LBLYYCQCTBFVLH-UHFFFAOYSA-M 0.000 claims 2
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 2
- 125000004011 3 membered carbocyclic group Chemical group 0.000 claims 1
- 125000001845 4 membered carbocyclic group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 238000009206 nuclear medicine Methods 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 C1*2C=CN*C12 Chemical compound C1*2C=CN*C12 0.000 description 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54486104P | 2004-02-13 | 2004-02-13 | |
| US60/544,861 | 2004-02-13 | ||
| US11/055,498 | 2005-02-10 | ||
| US11/055,498 US7344702B2 (en) | 2004-02-13 | 2005-02-10 | Contrast agents for myocardial perfusion imaging |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553329A Division JP5417578B2 (ja) | 2004-02-13 | 2005-02-11 | 心筋灌流イメージングのための造影剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014170803A Division JP6124848B2 (ja) | 2004-02-13 | 2014-08-25 | 心筋灌流イメージングのための造影剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013047277A JP2013047277A (ja) | 2013-03-07 |
| JP2013047277A5 true JP2013047277A5 (enExample) | 2013-12-26 |
| JP5847065B2 JP5847065B2 (ja) | 2016-01-20 |
Family
ID=34889838
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553329A Expired - Lifetime JP5417578B2 (ja) | 2004-02-13 | 2005-02-11 | 心筋灌流イメージングのための造影剤 |
| JP2012263291A Expired - Lifetime JP5847065B2 (ja) | 2004-02-13 | 2012-11-30 | 心筋灌流イメージングのための造影剤 |
| JP2014170803A Expired - Fee Related JP6124848B2 (ja) | 2004-02-13 | 2014-08-25 | 心筋灌流イメージングのための造影剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006553329A Expired - Lifetime JP5417578B2 (ja) | 2004-02-13 | 2005-02-11 | 心筋灌流イメージングのための造影剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014170803A Expired - Fee Related JP6124848B2 (ja) | 2004-02-13 | 2014-08-25 | 心筋灌流イメージングのための造影剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US7344702B2 (enExample) |
| EP (2) | EP1713512B1 (enExample) |
| JP (3) | JP5417578B2 (enExample) |
| KR (2) | KR101386851B1 (enExample) |
| CN (2) | CN1925878B (enExample) |
| AU (1) | AU2005214898C1 (enExample) |
| BR (1) | BRPI0507684B8 (enExample) |
| CA (3) | CA2556213C (enExample) |
| DK (2) | DK3385253T3 (enExample) |
| ES (2) | ES2665687T3 (enExample) |
| IL (4) | IL177275A0 (enExample) |
| IN (1) | IN2012DN02610A (enExample) |
| MX (1) | MX348859B (enExample) |
| NO (2) | NO344857B1 (enExample) |
| PT (1) | PT1713512T (enExample) |
| RU (2) | RU2457865C2 (enExample) |
| SG (1) | SG149895A1 (enExample) |
| WO (1) | WO2005079391A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7344702B2 (en) * | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| US7485283B2 (en) * | 2004-04-28 | 2009-02-03 | Lantheus Medical Imaging | Contrast agents for myocardial perfusion imaging |
| US7824659B2 (en) | 2005-08-10 | 2010-11-02 | Lantheus Medical Imaging, Inc. | Methods of making radiolabeled tracers and precursors thereof |
| US8986650B2 (en) | 2005-10-07 | 2015-03-24 | Guerbet | Complex folate-NOTA-Ga68 |
| US8926945B2 (en) * | 2005-10-07 | 2015-01-06 | Guerbet | Compounds comprising a biological target recognizing part, coupled to a signal part capable of complexing gallium |
| US9259426B2 (en) * | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US8673929B2 (en) * | 2006-07-20 | 2014-03-18 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
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| WO2008128058A1 (en) * | 2007-04-13 | 2008-10-23 | The Trustees Of The University Of Pennsylvania | New gallium bisaminothiolate complexes for myocardial imaging |
| AU2015200027B2 (en) * | 2008-02-29 | 2017-01-19 | Lantheus Medical Imaging, Inc. | Contrast agents for applications including perfusion imaging |
| ES2767973T3 (es) * | 2008-02-29 | 2020-06-19 | Lantheus Medical Imaging Inc | Agentes de contraste para aplicaciones que comprenden formación de imágenes de perfusión |
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| CN110312704A (zh) * | 2017-03-07 | 2019-10-08 | 日本医事物理股份有限公司 | 放射性氟标记前体化合物及使用其的放射性氟标记化合物的制造方法 |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
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| TWI879779B (zh) | 2019-06-28 | 2025-04-11 | 美商基利科學股份有限公司 | 類鐸受體調節劑化合物的製備方法 |
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| CN114832118B (zh) * | 2022-07-04 | 2022-09-27 | 北京先通国际医药科技股份有限公司 | 化合物i液体组合物、制备方法及其用途 |
| CN116082670B (zh) * | 2023-04-11 | 2023-06-27 | 中国人民解放军军事科学院军事医学研究院 | 一种含有季膦盐的声响应假性共轭聚合物纳米颗粒的制备方法及其在抗菌领域的应用 |
| WO2025212569A1 (en) | 2024-04-05 | 2025-10-09 | Park City Bio, LLC | Selective serotonin receptor modultors and methods of making and using the same |
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