JP5787873B2 - インビボイメージング用の放射性標識ピリジニル誘導体 - Google Patents

インビボイメージング用の放射性標識ピリジニル誘導体 Download PDF

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Publication number
JP5787873B2
JP5787873B2 JP2012500269A JP2012500269A JP5787873B2 JP 5787873 B2 JP5787873 B2 JP 5787873B2 JP 2012500269 A JP2012500269 A JP 2012500269A JP 2012500269 A JP2012500269 A JP 2012500269A JP 5787873 B2 JP5787873 B2 JP 5787873B2
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Japan
Prior art keywords
contrast agent
vivo
pbr
compound
precursor
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Expired - Fee Related
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JP2012500269A
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English (en)
Japanese (ja)
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JP2012520855A (ja
JP2012520855A5 (enExample
Inventor
ワズワース、ハリー・ジョン
トリッグ、ウィリアム・ジョン
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GE Healthcare Ltd
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GE Healthcare Ltd
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2012500269A 2009-03-19 2010-03-19 インビボイメージング用の放射性標識ピリジニル誘導体 Expired - Fee Related JP5787873B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16142509P 2009-03-19 2009-03-19
US61/161,425 2009-03-19
GB0904715.0 2009-03-19
GBGB0904715.0A GB0904715D0 (en) 2009-03-19 2009-03-19 Aryloxyanilide derivataives
PCT/EP2010/053614 WO2010106166A2 (en) 2009-03-19 2010-03-19 Aryloxyanilide derivatives

Publications (3)

Publication Number Publication Date
JP2012520855A JP2012520855A (ja) 2012-09-10
JP2012520855A5 JP2012520855A5 (enExample) 2013-05-02
JP5787873B2 true JP5787873B2 (ja) 2015-09-30

Family

ID=40639799

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012500269A Expired - Fee Related JP5787873B2 (ja) 2009-03-19 2010-03-19 インビボイメージング用の放射性標識ピリジニル誘導体

Country Status (6)

Country Link
US (1) US20120003154A1 (enExample)
EP (1) EP2408451A2 (enExample)
JP (1) JP5787873B2 (enExample)
CN (1) CN102355899B (enExample)
GB (1) GB0904715D0 (enExample)
WO (1) WO2010106166A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0921967D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel Aryloxyanilide Derivatives
KR101602912B1 (ko) * 2013-09-13 2016-03-11 주식회사 바이오이미징코리아 [18ｆ]플루오르메틸기가 도입된 뇌신경염증 표적 양성자방출단층촬영 방사성추적자, 이의 합성 및 그를 이용한 생물학적 결과 평가 방법
US10940685B2 (en) * 2015-12-28 2021-03-09 The Procter & Gamble Company Method and apparatus for applying a material onto articles using a transfer component that deflects on both sides
US10369807B2 (en) * 2016-05-06 2019-08-06 Entrust Datacard Corporation Label module for printing custom customer engagement labels
CN119409686B (zh) * 2025-01-07 2025-09-05 四川大学华西医院 苯杂氮卓类衍生物、放射性探针及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4302207B2 (ja) * 1997-08-04 2009-07-22 大正製薬株式会社 アリールオキシアニリン誘導体
DE69809063T2 (de) * 1997-08-04 2003-06-12 Nihon Nohyaku Co., Ltd. Aryloxyanilin-derivate
JP2000001476A (ja) * 1998-06-15 2000-01-07 Taisho Pharmaceut Co Ltd アリールオキシ含窒素アリールアミン誘導体
GB0115927D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
US6870069B2 (en) 2003-01-10 2005-03-22 National Institute Of Radiological Sciences Phenyloxyaniline derivatives
RU2425824C2 (ru) 2005-02-28 2011-08-10 Тайсо Фармасьютикал Ко., Лтд. Производные фенилоксианилина, меченные радиоактивным галогеном
WO2007036785A2 (en) 2005-09-29 2007-04-05 Ge Healthcare Limited Carbon-isotope monoxide labeling of daa1106 and its analogues to be used as tracers for a peripheral type benzodiazepine binding site
WO2007074383A1 (en) * 2005-12-28 2007-07-05 Ge Healthcare Limited 18f-labeled phenoxyphenyl n-benzyl alkanamid derivatives for positron emission tomography (pet) imaging of peripheral benzodiazepine receptor
WO2010015340A1 (en) 2008-08-06 2010-02-11 Bayer Schering Pharma Aktiengesellschaft Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment

Also Published As

Publication number Publication date
US20120003154A1 (en) 2012-01-05
JP2012520855A (ja) 2012-09-10
WO2010106166A3 (en) 2011-03-31
EP2408451A2 (en) 2012-01-25
CN102355899B (zh) 2015-10-07
WO2010106166A2 (en) 2010-09-23
GB0904715D0 (en) 2009-05-06
CN102355899A (zh) 2012-02-15

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