MX2007010343A - Derivados de feniloxianilina etiquetados con halogeno radiactivo. - Google Patents
Derivados de feniloxianilina etiquetados con halogeno radiactivo.Info
- Publication number
- MX2007010343A MX2007010343A MX2007010343A MX2007010343A MX2007010343A MX 2007010343 A MX2007010343 A MX 2007010343A MX 2007010343 A MX2007010343 A MX 2007010343A MX 2007010343 A MX2007010343 A MX 2007010343A MX 2007010343 A MX2007010343 A MX 2007010343A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- radioactive halogen
- pbr
- labeled
- alkoxy group
- Prior art date
Links
- 230000002285 radioactive effect Effects 0.000 title abstract 5
- 229910052736 halogen Inorganic materials 0.000 title abstract 3
- 150000002367 halogens Chemical class 0.000 title abstract 3
- GYNAVKULVOETAD-UHFFFAOYSA-N n-phenoxyaniline Chemical class C=1C=CC=CC=1NOC1=CC=CC=C1 GYNAVKULVOETAD-UHFFFAOYSA-N 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 239000003446 ligand Substances 0.000 abstract 2
- 238000005259 measurement Methods 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000002603 single-photon emission computed tomography Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/04—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
- C07C233/07—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/88—Carboxylic acid amides having nitrogen atoms of carboxamide groups bound to an acyclic carbon atom and to a carbon atom of a six-membered aromatic ring wherein at least one ortho-hydrogen atom has been replaced
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un derivado de feniloxianilina etiquetado con halogeno radiactivo representado por la siguiente formula: en donde R1 representa un grupo tal como un grupo alquilo; X1, X2, X3 y X4 representan cada uno un atomo de hidrogeno, un grupo alquilo, un grupo alcoxi, un grupo alcoxi que contiene 11C introducido en el mismo o un atomo de halogeno radiactivo, con la salvedad de que al menos uno de X1, X2, X3 y X4 representan un grupo alcoxi que contiene 11C introducido en el mismo o un atomo de halogeno radiactivo; que es un compuesto util como un ligando de PBR que tiene una alta afinidad y una alta selectividad. En la medicion in vitro del PBR, un ligando de PBR que tiene una alta afinidad y una alta selectividad, se etiqueta con una especia nuclear de halogeno radiactivo a fin de permitir la medicion del PBR en vivo con el uso de medios que incluyen no solo PET sino tambien SPECT. Por consiguiente, puede obtenerse un compuesto util en el diagnostico temprano, la prevencion y el tratamiento de enfermedades tales como demencia tipo Alzheimer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005052527 | 2005-02-28 | ||
| PCT/JP2005/024075 WO2006092902A1 (ja) | 2005-02-28 | 2005-12-28 | 放射性ハロゲン標識フェニルオキシアニリン誘導体 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2007010343A true MX2007010343A (es) | 2008-04-16 |
Family
ID=36940944
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2007010343A MX2007010343A (es) | 2005-02-28 | 2005-12-28 | Derivados de feniloxianilina etiquetados con halogeno radiactivo. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20090234162A1 (es) |
| EP (1) | EP1854781A1 (es) |
| JP (1) | JPWO2006092902A1 (es) |
| KR (1) | KR20070108883A (es) |
| CN (1) | CN101133017A (es) |
| AU (1) | AU2005328464B2 (es) |
| BR (1) | BRPI0520092A2 (es) |
| CA (1) | CA2599321A1 (es) |
| IL (1) | IL185333A0 (es) |
| MX (1) | MX2007010343A (es) |
| NO (1) | NO20074897L (es) |
| RU (1) | RU2425824C2 (es) |
| UA (1) | UA93870C2 (es) |
| WO (1) | WO2006092902A1 (es) |
| ZA (1) | ZA200707226B (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100040545A1 (en) * | 2006-12-21 | 2010-02-18 | Erik Arstad | Radiolabelling methods |
| EP2120717A1 (en) * | 2007-03-12 | 2009-11-25 | National Institute of Radiological Sciences | Pet visualization of amyloid-associated neuroinflammation in the brain |
| EP1997515A1 (en) * | 2007-05-30 | 2008-12-03 | Bayer Schering Pharma Aktiengesellschaft | Use of radiolabelled phenyloxyaniline derivatives for imaging diseases associated with peripheral benzodiazepin receptor's activation |
| JP5441060B2 (ja) * | 2007-10-31 | 2014-03-12 | 独立行政法人理化学研究所 | 創薬のためのｐｅｔスクリーニング用分子プローブを製造するためのキット |
| GB0722779D0 (en) | 2007-11-20 | 2008-01-02 | Sterix Ltd | Compound |
| GB0904715D0 (en) | 2009-03-19 | 2009-05-06 | Ge Healthcare Ltd | Aryloxyanilide derivataives |
| GB0921967D0 (en) | 2009-12-17 | 2010-02-03 | Ge Healthcare Ltd | Novel Aryloxyanilide Derivatives |
| WO2014097474A1 (ja) * | 2012-12-21 | 2014-06-26 | 独立行政法人放射線医学総合研究所 | 脳内に蓄積したタウタンパク質をイメージングするための新規化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5122361A (en) * | 1989-04-17 | 1992-06-16 | Trustees Of The University Of Pennsylvania | Dopamine receptor ligands and imaging agents |
| US5993777A (en) * | 1993-05-06 | 1999-11-30 | Research Corporation Technologies, Inc. | Benzamide compounds for cancer imaging and therapy |
| JP4302207B2 (ja) * | 1997-08-04 | 2009-07-22 | 大正製薬株式会社 | アリールオキシアニリン誘導体 |
| WO1999006353A1 (fr) * | 1997-08-04 | 1999-02-11 | Taisho Pharmaceutical Co., Ltd. | Derives aryloxyaniline |
| US6843979B2 (en) * | 1999-04-26 | 2005-01-18 | Emory University | 4-haloethenylphenyl tropane:serotonin transporter imaging agents |
| US6399042B1 (en) * | 1999-04-26 | 2002-06-04 | Emory University | 4-fluoroalkyl-3-halophenyl nortropanes |
| US6870069B2 (en) * | 2003-01-10 | 2005-03-22 | National Institute Of Radiological Sciences | Phenyloxyaniline derivatives |
-
2005
- 2005-12-28 JP JP2007505812A patent/JPWO2006092902A1/ja active Pending
- 2005-12-28 EP EP05822458A patent/EP1854781A1/en not_active Withdrawn
- 2005-12-28 AU AU2005328464A patent/AU2005328464B2/en not_active Ceased
- 2005-12-28 ZA ZA200707226A patent/ZA200707226B/xx unknown
- 2005-12-28 UA UAA200710682A patent/UA93870C2/ru unknown
- 2005-12-28 KR KR1020077019539A patent/KR20070108883A/ko not_active Application Discontinuation
- 2005-12-28 WO PCT/JP2005/024075 patent/WO2006092902A1/ja active Application Filing
- 2005-12-28 CA CA002599321A patent/CA2599321A1/en not_active Abandoned
- 2005-12-28 BR BRPI0520092-0A patent/BRPI0520092A2/pt not_active IP Right Cessation
- 2005-12-28 RU RU2007135882/04A patent/RU2425824C2/ru not_active IP Right Cessation
- 2005-12-28 US US11/884,763 patent/US20090234162A1/en not_active Abandoned
- 2005-12-28 CN CNA2005800488048A patent/CN101133017A/zh active Pending
- 2005-12-28 MX MX2007010343A patent/MX2007010343A/es not_active Application Discontinuation
-
2007
- 2007-08-16 IL IL185333A patent/IL185333A0/en unknown
- 2007-09-26 NO NO20074897A patent/NO20074897L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200707226B (en) | 2009-09-30 |
| EP1854781A1 (en) | 2007-11-14 |
| AU2005328464B2 (en) | 2011-02-24 |
| CA2599321A1 (en) | 2006-09-08 |
| BRPI0520092A2 (pt) | 2009-08-18 |
| UA93870C2 (ru) | 2011-03-25 |
| IL185333A0 (en) | 2008-02-09 |
| KR20070108883A (ko) | 2007-11-13 |
| WO2006092902A1 (ja) | 2006-09-08 |
| RU2007135882A (ru) | 2009-04-10 |
| NO20074897L (no) | 2007-11-21 |
| JPWO2006092902A1 (ja) | 2008-08-07 |
| AU2005328464A1 (en) | 2006-09-08 |
| RU2425824C2 (ru) | 2011-08-10 |
| US20090234162A1 (en) | 2009-09-17 |
| CN101133017A (zh) | 2008-02-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |