CN102355899B - 用于体内成像的放射性标记的吡啶基衍生物 - Google Patents

用于体内成像的放射性标记的吡啶基衍生物 Download PDF

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Publication number
CN102355899B
CN102355899B CN201080012633.4A CN201080012633A CN102355899B CN 102355899 B CN102355899 B CN 102355899B CN 201080012633 A CN201080012633 A CN 201080012633A CN 102355899 B CN102355899 B CN 102355899B
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CN
China
Prior art keywords
vivo imaging
imaging agent
pbr
compound
vivo
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201080012633.4A
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English (en)
Chinese (zh)
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CN102355899A (zh
Inventor
H·J·沃兹沃思
W·J·特里格
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of CN102355899A publication Critical patent/CN102355899A/zh
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Publication of CN102355899B publication Critical patent/CN102355899B/zh
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201080012633.4A 2009-03-19 2010-03-19 用于体内成像的放射性标记的吡啶基衍生物 Expired - Fee Related CN102355899B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16142509P 2009-03-19 2009-03-19
US61/161425 2009-03-19
GB0904715.0 2009-03-19
GBGB0904715.0A GB0904715D0 (en) 2009-03-19 2009-03-19 Aryloxyanilide derivataives
PCT/EP2010/053614 WO2010106166A2 (en) 2009-03-19 2010-03-19 Aryloxyanilide derivatives

Publications (2)

Publication Number Publication Date
CN102355899A CN102355899A (zh) 2012-02-15
CN102355899B true CN102355899B (zh) 2015-10-07

Family

ID=40639799

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201080012633.4A Expired - Fee Related CN102355899B (zh) 2009-03-19 2010-03-19 用于体内成像的放射性标记的吡啶基衍生物

Country Status (6)

Country Link
US (1) US20120003154A1 (enExample)
EP (1) EP2408451A2 (enExample)
JP (1) JP5787873B2 (enExample)
CN (1) CN102355899B (enExample)
GB (1) GB0904715D0 (enExample)
WO (1) WO2010106166A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0921967D0 (en) * 2009-12-17 2010-02-03 Ge Healthcare Ltd Novel Aryloxyanilide Derivatives
KR101602912B1 (ko) * 2013-09-13 2016-03-11 주식회사 바이오이미징코리아 [18ｆ]플루오르메틸기가 도입된 뇌신경염증 표적 양성자방출단층촬영 방사성추적자, 이의 합성 및 그를 이용한 생물학적 결과 평가 방법
US10940685B2 (en) * 2015-12-28 2021-03-09 The Procter & Gamble Company Method and apparatus for applying a material onto articles using a transfer component that deflects on both sides
EP3452294B1 (en) * 2016-05-06 2023-10-11 Entrust Corporation Label module for printing custom customer engagement labels
CN119409686B (zh) * 2025-01-07 2025-09-05 四川大学华西医院 苯杂氮卓类衍生物、放射性探针及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000001476A (ja) * 1998-06-15 2000-01-07 Taisho Pharmaceut Co Ltd アリールオキシ含窒素アリールアミン誘導体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1004573T3 (da) * 1997-08-04 2003-03-03 Nihon Nohyaku Co Ltd Aryloxyanilinderivater
JP4302207B2 (ja) * 1997-08-04 2009-07-22 大正製薬株式会社 アリールオキシアニリン誘導体
GB0115927D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase nucleophilic fluorination
GB0115929D0 (en) 2001-06-29 2001-08-22 Nycomed Amersham Plc Solid-phase electrophilic fluorination
US6870069B2 (en) 2003-01-10 2005-03-22 National Institute Of Radiological Sciences Phenyloxyaniline derivatives
EP1854781A1 (en) 2005-02-28 2007-11-14 Taisho Pharmaceutical Co., Ltd Radioactive halogen-labeled phenyloxyaniline derivatives
WO2007036785A2 (en) 2005-09-29 2007-04-05 Ge Healthcare Limited Carbon-isotope monoxide labeling of daa1106 and its analogues to be used as tracers for a peripheral type benzodiazepine binding site
WO2007074383A1 (en) 2005-12-28 2007-07-05 Ge Healthcare Limited 18f-labeled phenoxyphenyl n-benzyl alkanamid derivatives for positron emission tomography (pet) imaging of peripheral benzodiazepine receptor
WO2010015340A1 (en) * 2008-08-06 2010-02-11 Bayer Schering Pharma Aktiengesellschaft Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000001476A (ja) * 1998-06-15 2000-01-07 Taisho Pharmaceut Co Ltd アリールオキシ含窒素アリールアミン誘導体

Also Published As

Publication number Publication date
JP5787873B2 (ja) 2015-09-30
JP2012520855A (ja) 2012-09-10
CN102355899A (zh) 2012-02-15
US20120003154A1 (en) 2012-01-05
EP2408451A2 (en) 2012-01-25
WO2010106166A3 (en) 2011-03-31
WO2010106166A2 (en) 2010-09-23
GB0904715D0 (en) 2009-05-06

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CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20151007

Termination date: 20160319

CF01 Termination of patent right due to non-payment of annual fee