JP2012523388A - プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング - Google Patents

プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング Download PDF

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Publication number
JP2012523388A
JP2012523388A JP2012503993A JP2012503993A JP2012523388A JP 2012523388 A JP2012523388 A JP 2012523388A JP 2012503993 A JP2012503993 A JP 2012503993A JP 2012503993 A JP2012503993 A JP 2012503993A JP 2012523388 A JP2012523388 A JP 2012523388A
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JP
Japan
Prior art keywords
vivo imaging
imaging agent
subject
agent according
precursor
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Withdrawn
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JP2012503993A
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English (en)
Japanese (ja)
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JP2012523388A5 (enExample
Inventor
アレクザンドラー ジャクソン，
モリソン・アイベソン・ベロニック
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GE Healthcare Ltd
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GE Healthcare Ltd
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Publication of JP2012523388A publication Critical patent/JP2012523388A/ja
Publication of JP2012523388A5 publication Critical patent/JP2012523388A5/ja
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Optics & Photonics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2012503993A 2009-04-09 2010-04-06 プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング Withdrawn JP2012523388A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16789309P 2009-04-09 2009-04-09
US61/167,893 2009-04-09
GBGB0906274.6A GB0906274D0 (en) 2009-04-09 2009-04-09 Imaging the central nervous system
GB0906274.6 2009-04-09
PCT/EP2010/054517 WO2010115881A1 (en) 2009-04-09 2010-04-06 Imaging the central nervous system with purinergic p2x7 receptor binding agents

Publications (2)

Publication Number Publication Date
JP2012523388A true JP2012523388A (ja) 2012-10-04
JP2012523388A5 JP2012523388A5 (enExample) 2013-05-16

Family

ID=40750455

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012503993A Withdrawn JP2012523388A (ja) 2009-04-09 2010-04-06 プリン作動性ｐ２ｘ７受容体結合剤を用いた中枢神経系のイメージング

Country Status (6)

Country Link
US (1) US20120034165A1 (enExample)
EP (1) EP2416808A1 (enExample)
JP (1) JP2012523388A (enExample)
CN (1) CN102834120A (enExample)
GB (1) GB0906274D0 (enExample)
WO (1) WO2010115881A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2474523T3 (da) 2006-12-26 2020-07-13 Lantheus Medical Imaging Inc Ligander til billeddannelse af hjerte-innervation
CN106977429B (zh) 2010-05-11 2021-08-24 蓝瑟斯医学影像公司 用于合成和使用造影剂的组合物、方法和系统
CA2818253A1 (en) * 2010-11-16 2012-05-24 Denis G. Kay Method for increasing neprilysin expression and activity
DK2753605T3 (da) 2011-09-09 2019-06-17 Lantheus Medical Imaging Inc Sammensætninger, fremgangsmåder, og systemer til syntesen og anvendelsen af billeddannelsesmidler
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2627114A1 (en) * 2005-11-07 2007-05-18 Abbott Laboratories P2x7 receptor antagonists and methods of use
CA2645652A1 (en) 2006-03-16 2007-09-27 Renovis, Inc. Bicycloheteroaryl compounds as p2x7 modulators and uses thereof
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
EP2040700B1 (en) 2006-06-06 2010-11-24 Glaxo Group Limited N- (phenylmethyl) -2- (1h-pyraz0l-4-yl) acetamide derivatives as p2x7 antagonists for the treatment of pain, inflammation and neurodegeneration
WO2008064432A1 (en) 2006-12-01 2008-06-05 The University Of Sydney Polycyclic molecular compounds
GB0803729D0 (en) * 2008-02-29 2008-04-09 Ge Healthcare Ltd Imaging the central nervous system

Also Published As

Publication number Publication date
CN102834120A (zh) 2012-12-19
US20120034165A1 (en) 2012-02-09
WO2010115881A1 (en) 2010-10-14
EP2416808A1 (en) 2012-02-15
GB0906274D0 (en) 2009-05-20

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