JP2018529649A5 - - Google Patents
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- Publication number
- JP2018529649A5 JP2018529649A5 JP2018507019A JP2018507019A JP2018529649A5 JP 2018529649 A5 JP2018529649 A5 JP 2018529649A5 JP 2018507019 A JP2018507019 A JP 2018507019A JP 2018507019 A JP2018507019 A JP 2018507019A JP 2018529649 A5 JP2018529649 A5 JP 2018529649A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- heterocyclyl
- hydrogen
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000001257 hydrogen Substances 0.000 claims 46
- 229910052739 hydrogen Inorganic materials 0.000 claims 46
- 125000000547 substituted alkyl group Chemical group 0.000 claims 46
- 150000002431 hydrogen Chemical class 0.000 claims 40
- 125000000623 heterocyclic group Chemical group 0.000 claims 33
- 150000003839 salts Chemical class 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 24
- 125000001072 heteroaryl group Chemical group 0.000 claims 24
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 24
- 125000003107 substituted aryl group Chemical group 0.000 claims 24
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 229910052736 halogen Inorganic materials 0.000 claims 17
- 150000002367 halogens Chemical class 0.000 claims 17
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 15
- -1 carboxyacrylyl Chemical group 0.000 claims 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 12
- 125000002252 acyl group Chemical group 0.000 claims 10
- 125000004429 atom Chemical group 0.000 claims 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 7
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562204385P | 2015-08-12 | 2015-08-12 | |
| US62/204,385 | 2015-08-12 | ||
| US201562253030P | 2015-11-09 | 2015-11-09 | |
| US62/253,030 | 2015-11-09 | ||
| PCT/US2016/046889 WO2017027841A1 (en) | 2015-08-12 | 2016-08-12 | Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018529649A JP2018529649A (ja) | 2018-10-11 |
| JP2018529649A5 true JP2018529649A5 (enExample) | 2019-09-26 |
Family
ID=56740558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018507019A Pending JP2018529649A (ja) | 2015-08-12 | 2016-08-12 | フェニルスルホンアミド−ベンゾフラン誘導体およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10975051B2 (enExample) |
| EP (1) | EP3334713B1 (enExample) |
| JP (1) | JP2018529649A (enExample) |
| CN (1) | CN108349924A (enExample) |
| AU (2) | AU2016306694B2 (enExample) |
| CA (1) | CA2990477A1 (enExample) |
| WO (2) | WO2017027841A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017027841A1 (en) | 2015-08-12 | 2017-02-16 | Memorial Sloan-Kettering Cancer Center | Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases |
| WO2017087810A1 (en) * | 2015-11-20 | 2017-05-26 | Memorial Sloan-Kettering Cancer Center | Method for screening inhibitors targeting anti-apoptotic survival pathways |
| JP2019103077A (ja) * | 2017-12-07 | 2019-06-24 | Kddi株式会社 | 管理装置、管理方法、管理プログラム及び通信システム |
| CN111904958B (zh) * | 2019-05-09 | 2022-09-13 | 浙江大学 | Umi-77作为线粒体自噬诱导剂在制备治疗炎症及神经退行性疾病药物中的应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2665444B1 (fr) | 1990-08-06 | 1992-11-27 | Sanofi Sa | Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant. |
| EP1161444A4 (en) * | 1999-02-26 | 2005-11-02 | Univ Johns Hopkins | A novel inhibitor of programmed cell death |
| AR031130A1 (es) | 2000-09-20 | 2003-09-10 | Abbott Lab | N-acilsulfonamidas promotoras de la apoptosis |
| NZ529792A (en) | 2001-05-30 | 2007-04-27 | Univ Michigan | Small molecule antagonists of Bcl-2 family proteins |
| WO2003038060A2 (en) | 2001-11-01 | 2003-05-08 | The Regents Of The University Of Michigan | Small molecule inhibitors targeted at bcl-2 |
| US20050085420A1 (en) * | 2003-07-22 | 2005-04-21 | Stanley Korsmeyer | Method of modulating apoptosis and compositions thereof |
| WO2008017123A1 (en) | 2006-08-11 | 2008-02-14 | The Walter And Eliza Hall Institute Of Medical Research | Methods for modulating apoptosis in platelets |
| EP3124494B1 (en) * | 2008-12-09 | 2019-06-19 | Dana-Farber Cancer Institute, Inc. | Methods and compositions for specific modulation of mcl-1 |
| EA020586B1 (ru) * | 2009-09-10 | 2014-12-30 | Новартис Аг | СУЛЬФОНАМИДЫ В КАЧЕСТВЕ ИНГИБИТОРОВ БЕЛКОВ СЕМЕЙСТВА Bcl-2, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ ЛЕЧЕНИЯ РАКА |
| US8501811B2 (en) | 2010-06-17 | 2013-08-06 | Washington University | TASPASE1 inhibitors and their uses |
| FR2962649B1 (fr) | 2010-07-19 | 2025-10-24 | Conservatoire Nat Arts Et Metiers | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
| EP2619184B1 (en) | 2010-09-24 | 2018-05-23 | The Regents of the University of Michigan | Deubiquitinase inhibitors and methods for use of the same |
| US20140296223A1 (en) | 2011-09-01 | 2014-10-02 | The General Hospital Corporation | Method for regulating skin pigmentation |
| US9744171B2 (en) | 2012-03-06 | 2017-08-29 | Vanderbilt University | Positive allosteric modulators for melanocortin receptors |
| US10093640B2 (en) | 2012-09-21 | 2018-10-09 | Vanderbilt University | Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors |
| WO2014109696A1 (en) | 2013-01-10 | 2014-07-17 | Alf Grandien | Method for immortalization of b cells and uses thereof |
| WO2017027841A1 (en) * | 2015-08-12 | 2017-02-16 | Memorial Sloan-Kettering Cancer Center | Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases |
| WO2017087810A1 (en) | 2015-11-20 | 2017-05-26 | Memorial Sloan-Kettering Cancer Center | Method for screening inhibitors targeting anti-apoptotic survival pathways |
-
2016
- 2016-08-12 WO PCT/US2016/046889 patent/WO2017027841A1/en not_active Ceased
- 2016-08-12 CA CA2990477A patent/CA2990477A1/en not_active Abandoned
- 2016-08-12 CN CN201680047716.4A patent/CN108349924A/zh active Pending
- 2016-08-12 US US15/751,943 patent/US10975051B2/en not_active Expired - Fee Related
- 2016-08-12 EP EP16754124.2A patent/EP3334713B1/en active Active
- 2016-08-12 JP JP2018507019A patent/JP2018529649A/ja active Pending
- 2016-08-12 WO PCT/US2016/046897 patent/WO2017027845A1/en not_active Ceased
- 2016-08-12 AU AU2016306694A patent/AU2016306694B2/en not_active Ceased
- 2016-08-12 US US15/752,126 patent/US11098021B2/en active Active
-
2021
- 2021-06-11 AU AU2021203883A patent/AU2021203883A1/en not_active Abandoned