JP2018529649A - フェニルスルホンアミド−ベンゾフラン誘導体およびその使用 - Google Patents

フェニルスルホンアミド−ベンゾフラン誘導体およびその使用 Download PDF

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Publication number
JP2018529649A
JP2018529649A JP2018507019A JP2018507019A JP2018529649A JP 2018529649 A JP2018529649 A JP 2018529649A JP 2018507019 A JP2018507019 A JP 2018507019A JP 2018507019 A JP2018507019 A JP 2018507019A JP 2018529649 A JP2018529649 A JP 2018529649A
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JP
Japan
Prior art keywords
optionally substituted
alkyl
pharmaceutically acceptable
compound
acceptable salt
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JP2018507019A
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English (en)
Japanese (ja)
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JP2018529649A5 (enExample
Inventor
チェン，エミリー，エイチ．
シーエ，ジェームス
ジェン，ポール
オーエルフェリ，クワテック
ヤン，グァンリ
Original Assignee
メモリアル スローン ケタリング キャンサー センター
メモリアル スローン ケタリング キャンサー センター
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Publication of JP2018529649A publication Critical patent/JP2018529649A/ja
Publication of JP2018529649A5 publication Critical patent/JP2018529649A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Furan Compounds (AREA)
JP2018507019A 2015-08-12 2016-08-12 フェニルスルホンアミド−ベンゾフラン誘導体およびその使用 Pending JP2018529649A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562204385P 2015-08-12 2015-08-12
US62/204,385 2015-08-12
US201562253030P 2015-11-09 2015-11-09
US62/253,030 2015-11-09
PCT/US2016/046889 WO2017027841A1 (en) 2015-08-12 2016-08-12 Phenylsulfonamido-benzofuran derivatives and uses thereof in the treatment of proliferative diseases

Publications (2)

Publication Number Publication Date
JP2018529649A true JP2018529649A (ja) 2018-10-11
JP2018529649A5 JP2018529649A5 (enExample) 2019-09-26

Family

ID=56740558

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018507019A Pending JP2018529649A (ja) 2015-08-12 2016-08-12 フェニルスルホンアミド−ベンゾフラン誘導体およびその使用

Country Status (7)

Country Link
US (2) US11098021B2 (enExample)
EP (1) EP3334713B1 (enExample)
JP (1) JP2018529649A (enExample)
CN (1) CN108349924A (enExample)
AU (2) AU2016306694B2 (enExample)
CA (1) CA2990477A1 (enExample)
WO (2) WO2017027845A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018529649A (ja) 2015-08-12 2018-10-11 メモリアル スローン ケタリング キャンサー センター フェニルスルホンアミド−ベンゾフラン誘導体およびその使用
WO2017087810A1 (en) * 2015-11-20 2017-05-26 Memorial Sloan-Kettering Cancer Center Method for screening inhibitors targeting anti-apoptotic survival pathways
JP2019103077A (ja) * 2017-12-07 2019-06-24 Kddi株式会社 管理装置、管理方法、管理プログラム及び通信システム
CN111904958B (zh) * 2019-05-09 2022-09-13 浙江大学 Umi-77作为线粒体自噬诱导剂在制备治疗炎症及神经退行性疾病药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004529852A (ja) * 2000-09-20 2004-09-30 アボット・ラボラトリーズ Ｎ−アシルスルホンアミド系アポトーシス促進剤
JP2013504536A (ja) * 2009-09-10 2013-02-07 ノバルティス アーゲー 癌の処置のためのｂｃｌ−２ファミリータンパク質阻害剤としてのスルホンアミド類
WO2014047427A2 (en) * 2012-09-21 2014-03-27 Vanderbilt University Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors

Family Cites Families (15)

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FR2665444B1 (fr) 1990-08-06 1992-11-27 Sanofi Sa Derives d'amino-benzofuranne, benzothiophene ou indole, leur procede de preparation ainsi que les compositions les contenant.
CA2363621A1 (en) * 1999-02-26 2000-08-31 The Johns Hopkins University A novel inhibitor of programmed cell death
KR20040108528A (ko) 2001-05-30 2004-12-24 더 리젠츠 오브 더 유니버시티 오브 미시간 Ｂｃｌ2 군 단백질의 소분자 길항제
WO2003038060A2 (en) 2001-11-01 2003-05-08 The Regents Of The University Of Michigan Small molecule inhibitors targeted at bcl-2
US20050085420A1 (en) 2003-07-22 2005-04-21 Stanley Korsmeyer Method of modulating apoptosis and compositions thereof
WO2008017123A1 (en) 2006-08-11 2008-02-14 The Walter And Eliza Hall Institute Of Medical Research Methods for modulating apoptosis in platelets
EP3124494B1 (en) * 2008-12-09 2019-06-19 Dana-Farber Cancer Institute, Inc. Methods and compositions for specific modulation of mcl-1
US8501811B2 (en) * 2010-06-17 2013-08-06 Washington University TASPASE1 inhibitors and their uses
FR2962649B1 (fr) * 2010-07-19 2025-10-24 Conservatoire Nat Arts Et Metiers Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide
CN103261169A (zh) 2010-09-24 2013-08-21 密歇根大学董事会 脱泛素酶抑制剂及其应用方法
JP2014529628A (ja) 2011-09-01 2014-11-13 ザ ジェネラル ホスピタル コーポレイション 皮膚色素沈着を調節するための方法
US9744171B2 (en) * 2012-03-06 2017-08-29 Vanderbilt University Positive allosteric modulators for melanocortin receptors
WO2014109696A1 (en) 2013-01-10 2014-07-17 Alf Grandien Method for immortalization of b cells and uses thereof
JP2018529649A (ja) 2015-08-12 2018-10-11 メモリアル スローン ケタリング キャンサー センター フェニルスルホンアミド−ベンゾフラン誘導体およびその使用
WO2017087810A1 (en) * 2015-11-20 2017-05-26 Memorial Sloan-Kettering Cancer Center Method for screening inhibitors targeting anti-apoptotic survival pathways

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004529852A (ja) * 2000-09-20 2004-09-30 アボット・ラボラトリーズ Ｎ−アシルスルホンアミド系アポトーシス促進剤
JP2013504536A (ja) * 2009-09-10 2013-02-07 ノバルティス アーゲー 癌の処置のためのｂｃｌ−２ファミリータンパク質阻害剤としてのスルホンアミド類
WO2014047427A2 (en) * 2012-09-21 2014-03-27 Vanderbilt University Substituted benzofuran, benzothiophene and indole mcl-1 inhibitors

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
AVDEENKO, A. P. ET AL., RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, vol. 47, JPN7020001775, 2011, pages 1169 - 1180, ISSN: 0004457480 *
REGISTRY（STN）[ONLINE], JPN7020001776, 12 April 2005 (2005-04-12), ISSN: 0004457481 *
REGISTRY（STN）[ONLINE], JPN7020001777, 12 April 2005 (2005-04-12), ISSN: 0004457482 *
REGISTRY（STN）[ONLINE], JPN7020001778, 12 April 2005 (2005-04-12), ISSN: 0004457483 *
REGISTRY（STN）[ONLINE], JPN7020001779, 12 April 2005 (2005-04-12), ISSN: 0004457484 *
REGISTRY（STN）[ONLINE], JPN7020001780, 12 April 2005 (2005-04-12), ISSN: 0004457485 *
REGISTRY（STN）[ONLINE], JPN7020001781, 12 April 2005 (2005-04-12), ISSN: 0004457486 *
REGISTRY（STN）[ONLINE], JPN7020001782, 12 April 2005 (2005-04-12), ISSN: 0004457487 *
REGISTRY（STN）[ONLINE], JPN7020001783, 9 September 2002 (2002-09-09), ISSN: 0004457488 *
REGISTRY（STN）[ONLINE], JPN7020001784, 21 March 2002 (2002-03-21), ISSN: 0004457489 *

Also Published As

Publication number Publication date
EP3334713A1 (en) 2018-06-20
US20180237407A1 (en) 2018-08-23
EP3334713B1 (en) 2021-07-21
AU2016306694B2 (en) 2021-03-11
CA2990477A1 (en) 2017-02-16
CN108349924A (zh) 2018-07-31
US10975051B2 (en) 2021-04-13
WO2017027845A1 (en) 2017-02-16
AU2021203883A1 (en) 2021-07-08
US11098021B2 (en) 2021-08-24
AU2016306694A1 (en) 2018-01-18
WO2017027841A1 (en) 2017-02-16
US20180237406A1 (en) 2018-08-23

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