JP2015520233A5 - - Google Patents
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- Publication number
- JP2015520233A5 JP2015520233A5 JP2015518483A JP2015518483A JP2015520233A5 JP 2015520233 A5 JP2015520233 A5 JP 2015520233A5 JP 2015518483 A JP2015518483 A JP 2015518483A JP 2015518483 A JP2015518483 A JP 2015518483A JP 2015520233 A5 JP2015520233 A5 JP 2015520233A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- androgen receptor
- related medical
- compound
- condition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100032187 Androgen receptor Human genes 0.000 claims 31
- 108010080146 androgen receptors Proteins 0.000 claims 28
- 239000008194 pharmaceutical composition Substances 0.000 claims 27
- 150000001875 compounds Chemical class 0.000 claims 18
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 208000027747 Kennedy disease Diseases 0.000 claims 6
- 125000002947 alkylene group Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 208000002874 Acne Vulgaris Diseases 0.000 claims 3
- 201000004384 Alopecia Diseases 0.000 claims 3
- 208000029402 Bulbospinal muscular atrophy Diseases 0.000 claims 3
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 claims 3
- 206010020112 Hirsutism Diseases 0.000 claims 3
- 206010061218 Inflammation Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 3
- 208000027418 Wounds and injury Diseases 0.000 claims 3
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 3
- 206010000496 acne Diseases 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 3
- 125000000304 alkynyl group Chemical group 0.000 claims 3
- 231100000360 alopecia Toxicity 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 230000028993 immune response Effects 0.000 claims 3
- 208000026278 immune system disease Diseases 0.000 claims 3
- 230000004054 inflammatory process Effects 0.000 claims 3
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 3
- 125000005504 styryl group Chemical group 0.000 claims 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 230000002159 abnormal effect Effects 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- -1 cyclopentanyl Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/525,941 US8710272B2 (en) | 2007-01-08 | 2012-06-18 | Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
| US13/525,941 | 2012-06-18 | ||
| PCT/US2013/046138 WO2013192091A1 (en) | 2012-06-18 | 2013-06-17 | Compounds with (1e, 6e)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disstituted-hepa-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018090272A Division JP2018135386A (ja) | 2012-06-18 | 2018-05-09 | （１ｅ，６ｅ）−１，７−ビス−（３，４−ジメトキシフェニル）−４，４−ジ置換−ヘプタ−１，６−ジエン−３，５−ジオン構造足場を伴う化合物、その生物活性、およびその使用 関連出願の相互参照 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015520233A JP2015520233A (ja) | 2015-07-16 |
| JP2015520233A5 true JP2015520233A5 (enExample) | 2016-09-15 |
| JP6392752B2 JP6392752B2 (ja) | 2018-09-19 |
Family
ID=49769258
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015518483A Active JP6392752B2 (ja) | 2012-06-18 | 2013-06-17 | （１ｅ，６ｅ）−１，７−ビス−（３，４−ジメトキシフェニル）−４，４−ジ置換−ヘプタ−１，６−ジエン−３，５−ジオン構造足場を伴う化合物、その生物活性、およびその使用 |
| JP2018090272A Abandoned JP2018135386A (ja) | 2012-06-18 | 2018-05-09 | （１ｅ，６ｅ）−１，７−ビス−（３，４−ジメトキシフェニル）−４，４−ジ置換−ヘプタ−１，６−ジエン−３，５−ジオン構造足場を伴う化合物、その生物活性、およびその使用 関連出願の相互参照 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018090272A Abandoned JP2018135386A (ja) | 2012-06-18 | 2018-05-09 | （１ｅ，６ｅ）−１，７−ビス−（３，４−ジメトキシフェニル）−４，４−ジ置換−ヘプタ−１，６−ジエン−３，５−ジオン構造足場を伴う化合物、その生物活性、およびその使用 関連出願の相互参照 |
Country Status (14)
| Country | Link |
|---|---|
| EP (3) | EP3549581A3 (enExample) |
| JP (2) | JP6392752B2 (enExample) |
| KR (1) | KR102171469B1 (enExample) |
| CN (3) | CN106220507A (enExample) |
| AU (1) | AU2013277423B2 (enExample) |
| CA (1) | CA2876957C (enExample) |
| DK (1) | DK3150203T3 (enExample) |
| ES (1) | ES2775173T3 (enExample) |
| HK (1) | HK1211211A1 (enExample) |
| IN (1) | IN2015MN00131A (enExample) |
| MX (1) | MX2014015936A (enExample) |
| NZ (1) | NZ703167A (enExample) |
| SG (1) | SG11201408387YA (enExample) |
| WO (1) | WO2013192091A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102693361B1 (ko) * | 2017-05-26 | 2024-08-09 | 브루인 바이오사이언시스, 인크. | 화학색전제 |
| CN107226783B (zh) * | 2017-06-20 | 2019-07-23 | 武汉工程大学 | 一种溶酶体靶向荧光探针及其制备方法 |
| EP3508855A1 (en) * | 2018-01-05 | 2019-07-10 | Allianz Pharmascience Ltd | Method for the selection of patients and kit |
| GB2572259B (en) * | 2018-03-23 | 2022-03-30 | Merry Life Biomedical Company Ltd | Uses of curcumin derivative |
| JP2020117489A (ja) * | 2019-01-04 | 2020-08-06 | アリアンツ ファーマサイエンス リミテッド | 脳癌の治療方法 |
| JP2020125285A (ja) * | 2019-01-04 | 2020-08-20 | アリアンツ ファーマサイエンス リミテッド | 神経変性性障害の治療方法 |
| CN110183320B (zh) * | 2019-04-15 | 2021-06-11 | 四川大学 | 一类多烯二酮类抗肿瘤化合物 |
| EP4516771A4 (en) * | 2022-04-29 | 2025-08-20 | Nanjing Minova Pharmaceutical Co Ltd | COMPOUND HAVING ANTI-ANDROGEN RECEPTOR ACTIVITY AND ITS USE |
| CN116120182A (zh) * | 2023-02-16 | 2023-05-16 | 常州大学 | 姜黄素衍生物及其合成方法和在抗雄激素受体中的应用 |
| CN116283676B (zh) * | 2023-03-24 | 2025-03-28 | 常州大学 | 一种姜黄素衍生物及其制备方法和应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US812408A (en) | 1905-08-19 | 1906-02-13 | Roy Ernest Dickerson | Educational device for teaching spherics. |
| US6790979B2 (en) * | 2002-04-17 | 2004-09-14 | University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
| US7355081B2 (en) * | 2002-04-17 | 2008-04-08 | The University Of North Carolina At Chapel Hill | Curcumin analogues and uses thereof |
| WO2008085984A1 (en) * | 2007-01-08 | 2008-07-17 | Androscience Corporation | Compounds with (substituted phenyl)-propenal moiety, their derivatives, biological activity, and uses thereof |
| KR20100051808A (ko) * | 2007-07-31 | 2010-05-18 | 앤드로사이언스 코포레이션 | 안드로겐 수용체 분해 강화제를 포함한 조성물 및 탈모와 피부질환의 예방 또는 치료 방법 |
| US20090282496A1 (en) * | 2008-04-04 | 2009-11-12 | University Of Rochester Medical Center | Androgen Receptor Related Methods for Treating Bladder Cancer |
-
2013
- 2013-06-17 CN CN201610580850.2A patent/CN106220507A/zh active Pending
- 2013-06-17 HK HK15112031.9A patent/HK1211211A1/xx unknown
- 2013-06-17 ES ES16187672T patent/ES2775173T3/es active Active
- 2013-06-17 EP EP19176039.6A patent/EP3549581A3/en not_active Withdrawn
- 2013-06-17 CA CA2876957A patent/CA2876957C/en active Active
- 2013-06-17 CN CN201910150761.8A patent/CN110279680A/zh active Pending
- 2013-06-17 EP EP16187672.7A patent/EP3150203B1/en active Active
- 2013-06-17 SG SG11201408387YA patent/SG11201408387YA/en unknown
- 2013-06-17 JP JP2015518483A patent/JP6392752B2/ja active Active
- 2013-06-17 EP EP13806162.7A patent/EP2861222A4/en not_active Ceased
- 2013-06-17 IN IN131MUN2015 patent/IN2015MN00131A/en unknown
- 2013-06-17 KR KR1020157000948A patent/KR102171469B1/ko active Active
- 2013-06-17 DK DK16187672.7T patent/DK3150203T3/da active
- 2013-06-17 NZ NZ703167A patent/NZ703167A/en unknown
- 2013-06-17 WO PCT/US2013/046138 patent/WO2013192091A1/en not_active Ceased
- 2013-06-17 CN CN201380040213.0A patent/CN104755076A/zh active Pending
- 2013-06-17 AU AU2013277423A patent/AU2013277423B2/en active Active
- 2013-06-17 MX MX2014015936A patent/MX2014015936A/es active IP Right Grant
-
2018
- 2018-05-09 JP JP2018090272A patent/JP2018135386A/ja not_active Abandoned
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