JP2011522822A5 - - Google Patents

Info

Publication number

JP2011522822A5

JP2011522822A5 JP2011512479A JP2011512479A JP2011522822A5 JP 2011522822 A5 JP2011522822 A5 JP 2011522822A5 JP 2011512479 A JP2011512479 A JP 2011512479A JP 2011512479 A JP2011512479 A JP 2011512479A JP 2011522822 A5 JP2011522822 A5 JP 2011522822A5

Authority

JP

Japan

Prior art keywords

formula

compound

prevention

treatment

butyl

Prior art date

2009-06-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 150000001875 compounds Chemical class 0.000 claims 10
• 230000002265 prevention Effects 0.000 claims 8
• 239000000203 mixture Substances 0.000 claims 3
• KOWBNNJAGJIIJW-UHFFFAOYSA-N octahydroxyanthraquinone Chemical compound OC1=C(O)C(O)=C2C(=O)C3=C(O)C(O)=C(O)C(O)=C3C(=O)C2=C1O KOWBNNJAGJIIJW-UHFFFAOYSA-N 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 102000000509 Estrogen Receptor beta Human genes 0.000 claims 2
• 108010041356 Estrogen Receptor beta Proteins 0.000 claims 2
• 206010027304 Menopausal symptoms Diseases 0.000 claims 2
• 239000004615 ingredient Substances 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 208000024172 Cardiovascular disease Diseases 0.000 claims 1
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• 208000033830 Hot Flashes Diseases 0.000 claims 1
• 206010060800 Hot flush Diseases 0.000 claims 1
• 208000001132 Osteoporosis Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims 1
• 206010046543 Urinary incontinence Diseases 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 208000002495 Uterine Neoplasms Diseases 0.000 claims 1
• 206010047791 Vulvovaginal dryness Diseases 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 230000003247 decreasing effect Effects 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940011871 estrogen Drugs 0.000 claims 1
• 239000000262 estrogen Substances 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• 206010022437 insomnia Diseases 0.000 claims 1
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
• 102000005962 receptors Human genes 0.000 claims 1
• 108020003175 receptors Proteins 0.000 claims 1
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
• -1 t - butyl Chemical group 0.000 claims 1
• LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
• 206010046766 uterine cancer Diseases 0.000 claims 1