MX338290B - Tratamiento de enfermedad de alzheimer, perdida de cognición, perdida de memoria y demencia con precursores de esteroides sexuales en conbinación con moduladores selectivos del receptor de estrógenos. - Google Patents

Tratamiento de enfermedad de alzheimer, perdida de cognición, perdida de memoria y demencia con precursores de esteroides sexuales en conbinación con moduladores selectivos del receptor de estrógenos.

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Publication number
MX338290B
MX338290B MX2011013689A MX2011013689A MX338290B MX 338290 B MX338290 B MX 338290B MX 2011013689 A MX2011013689 A MX 2011013689A MX 2011013689 A MX2011013689 A MX 2011013689A MX 338290 B MX338290 B MX 338290B
Authority
MX
Mexico
Prior art keywords
loss
estrogen receptor
selective estrogen
sex steroid
vasomotor symptoms
Prior art date
Application number
MX2011013689A
Other languages
English (en)
Other versions
MX2011013689A (es
Inventor
Fernand Labrie
Original Assignee
Endorech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43306950&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX338290(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Endorech Inc filed Critical Endorech Inc
Publication of MX2011013689A publication Critical patent/MX2011013689A/es
Publication of MX338290B publication Critical patent/MX338290B/es

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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
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    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Métodos novedosos para la reducción o eliminación de la incidencia de sofocos, síntomas vasomotores y sudores nocturnos al tiempo que disminuye el riesgo de sufrir de cáncer de mama, uterino o de endometrio y que además tiene un efecto beneficioso por inhibición del desarrollo de osteoporosis, hipercolesterolemia, hiperlipidemia, aterosclerosis, hipertensión, resistencia a insulina, diabetes tipo 2, pérdida de masa muscular, adiposidad, mal de Alzheimer, pérdida de cognición, pérdida de memoria o sequedad vaginal, en animales de sangre caliente susceptibles, inclusive seres humanos, que comprenden la administración de una cantidad de un precursor de esteroides sexuales, en particular dehidroepiandrosterona (DHEA), y un antiestrógeno o un modulador selectivo del receptor de estrógenos, en particular compuestos de la siguiente estructura general (ver fórmula) También se divulgan composiciones farmacéuticas para la administración de ingrediente(s) activo(s) de utilidad en la invención.
MX2011013689A 2009-06-16 2010-06-16 Tratamiento de enfermedad de alzheimer, perdida de cognición, perdida de memoria y demencia con precursores de esteroides sexuales en conbinación con moduladores selectivos del receptor de estrógenos. MX338290B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18754909P 2009-06-16 2009-06-16
US12/791,174 US20100317635A1 (en) 2009-06-16 2010-06-01 Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators
PCT/CA2010/000898 WO2010145010A1 (en) 2009-06-16 2010-06-16 Treatment of hot flushes, vasomotor symptoms, and night sweats with sex steroid precursors in combination with selective estrogen receptor modulators

Publications (2)

Publication Number Publication Date
MX2011013689A MX2011013689A (es) 2012-04-02
MX338290B true MX338290B (es) 2016-04-07

Family

ID=43306950

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011013689A MX338290B (es) 2009-06-16 2010-06-16 Tratamiento de enfermedad de alzheimer, perdida de cognición, perdida de memoria y demencia con precursores de esteroides sexuales en conbinación con moduladores selectivos del receptor de estrógenos.

Country Status (20)

Country Link
US (4) US20100317635A1 (es)
EP (3) EP2442807A4 (es)
JP (4) JP2012530074A (es)
KR (10) KR20210048609A (es)
CN (3) CN107468695A (es)
AR (1) AR077119A1 (es)
AU (1) AU2010262722A1 (es)
BR (1) BRPI1011561A2 (es)
CA (2) CA2893236A1 (es)
CL (1) CL2011003172A1 (es)
EA (1) EA201200016A1 (es)
HK (1) HK1204550A1 (es)
IL (2) IL216963A (es)
MA (1) MA33434B1 (es)
MX (1) MX338290B (es)
NZ (1) NZ597583A (es)
SG (3) SG10201705761YA (es)
TW (1) TWI612044B (es)
WO (1) WO2010145010A1 (es)
ZA (1) ZA201109198B (es)

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ES2545337T3 (es) 2011-07-19 2015-09-10 Pantarhei Bioscience B.V. Comprimido que contiene dehidroepiandrosterona (DHEA)
CA2857057A1 (en) 2011-12-14 2013-06-20 Seragon Pharmaceuticals, Inc. Fluorinated estrogen receptor modulators and uses thereof
CN104169266A (zh) 2011-12-16 2014-11-26 奥乐玛药物股份有限公司 新的苯并吡喃化合物、其组合物和用途
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WO2014008159A1 (en) * 2012-07-03 2014-01-09 The University Of North Carolina At Chapel Hill Selective estrogen receptor degraders for treatment of tamoxifen resistant tumors
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WO2014203132A1 (en) 2013-06-19 2014-12-24 Olema Pharmaceuticals, Inc. Substituted benzopyran compounds, compositions and uses thereof
CN103739456A (zh) * 2013-12-03 2014-04-23 镇江圣安医药有限公司 2-（对-（（z-4-氯-1,2-二苯基-1-丁烯基）苯氧基）乙醇的新型衍生物及其应用
US9744177B2 (en) 2014-03-10 2017-08-29 Endorecherche, Inc. Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with SERM
EP3288534B1 (en) 2015-04-28 2020-09-23 Symrise AG Compositions comprising valerian extracts
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WO2017162206A1 (zh) * 2016-03-25 2017-09-28 南京明德新药研发股份有限公司 作为雌激素受体降解剂的吲哚并取代哌啶类化合物
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