MA32477B1 - Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique - Google Patents

Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique

Info

Publication number
MA32477B1
MA32477B1 MA33521A MA33521A MA32477B1 MA 32477 B1 MA32477 B1 MA 32477B1 MA 33521 A MA33521 A MA 33521A MA 33521 A MA33521 A MA 33521A MA 32477 B1 MA32477 B1 MA 32477B1
Authority
MA
Morocco
Prior art keywords
stratrini
bioesostere
heterozygous
phenolic
estriene
Prior art date
Application number
MA33521A
Other languages
Arabic (ar)
English (en)
Inventor
Thorsten Blume
Dieter Heldmann
Norbert Schmees
Christiane Otto
Tim Wintermantel
Joachim Kuhnke
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of MA32477B1 publication Critical patent/MA32477B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0047—Nitrogen only at position 2(3)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

La présente invention concerne de nouveaux dérivés pyrazolo-estriènes et triazolo-estriènes, des compositions pharmaceutiques les contenant et leur utilisation dans le traitement ou la prévention de troubles et de maladies médiés par un récepteur d'sstrogène tels que les bouffées de chaleur, la sécheresse vaginale, l'ostéopénie, l'ostéoporose, l'hyperlipidémie, la perte de la fonction cognitive, les maladies cérébrales dégénératives, les maladies cardiovasculaires, les maladies cérébrovasculaires, les cancers hormono-sensibles et l'hyperplasie (dans les tissus comprenant le sein, l'endomètre, et le col de l'utérus chez les femmes, et la prostate chez les hommes), l'endométriosse, les fibroïdes utérins, l'arthrose ; et comme agents contraceptifs soit seuls soit en association avec un progestogène ou un antagoniste de progestogène. Les composés de l'invention sont des modulateurs sélectifs des récepteurs d'oestrogène.
MA33521A 2008-07-24 2011-01-14 Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique MA32477B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08161108A EP2147924A1 (fr) 2008-07-24 2008-07-24 Dérivés d'estratriènes comportant des bioisostères pour l'anneau phénolique
PCT/EP2009/005086 WO2010009828A1 (fr) 2008-07-24 2009-07-14 Dérivés estratriènes comprenant des dioisostères hétérocycliques pour le cycle a phénolique

Publications (1)

Publication Number Publication Date
MA32477B1 true MA32477B1 (fr) 2011-07-03

Family

ID=40329347

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33521A MA32477B1 (fr) 2008-07-24 2011-01-14 Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique

Country Status (24)

Country Link
US (1) US20110190246A1 (fr)
EP (2) EP2147924A1 (fr)
JP (1) JP2011528675A (fr)
KR (1) KR20110036739A (fr)
CN (1) CN102105484A (fr)
AR (1) AR072533A1 (fr)
AU (1) AU2009273494A1 (fr)
BR (1) BRPI0915987A2 (fr)
CA (1) CA2731634A1 (fr)
CL (1) CL2011000153A1 (fr)
CO (1) CO6351799A2 (fr)
CR (1) CR20110045A (fr)
DO (1) DOP2011000024A (fr)
EA (1) EA201100226A1 (fr)
EC (1) ECSP11010780A (fr)
IL (1) IL210314A0 (fr)
MA (1) MA32477B1 (fr)
MX (1) MX2011000939A (fr)
PE (1) PE20110402A1 (fr)
SV (1) SV2011003817A (fr)
TW (1) TW201008570A (fr)
UY (1) UY32005A (fr)
WO (1) WO2010009828A1 (fr)
ZA (1) ZA201101445B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011092127A1 (fr) * 2010-01-26 2011-08-04 Bayer Schering Pharma Aktiengesellschaft Dérivés d'estratriène 14,17-pontés comprenant des bioisostères hétérocycliques pour le noyau phénolique a
JP2023526568A (ja) * 2020-05-15 2023-06-21 シムサー ファーマシューティカル カンパニー リミテッド ピロリジン化合物及びその使用
DE102022109544A1 (de) 2022-04-20 2023-10-26 Eberspächer Catem Gmbh & Co. Kg Elektrische Heizvorrichtung
DE102022109556A1 (de) 2022-04-20 2023-10-26 Eberspächer Catem Gmbh & Co. Kg Elektrische Heizvorrichtung

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3458504A (en) * 1966-10-24 1969-07-29 Sterling Drug Inc Steroido(3,4-c)pyrazoles of the 5alpha- and 5beta-androstane series
DE60317109T2 (de) * 2002-07-03 2008-07-31 Ortho-Mcneil Pharmaceutical, Inc. Estrienoä3,2-bü/ä3,4-cüpyrrole derivative als modulatoren des östrogen rezeptors

Also Published As

Publication number Publication date
KR20110036739A (ko) 2011-04-08
JP2011528675A (ja) 2011-11-24
EA201100226A1 (ru) 2011-08-30
WO2010009828A1 (fr) 2010-01-28
CA2731634A1 (fr) 2010-01-28
ECSP11010780A (es) 2011-02-28
BRPI0915987A2 (pt) 2019-09-24
CN102105484A (zh) 2011-06-22
AR072533A1 (es) 2010-09-01
CR20110045A (es) 2012-05-28
UY32005A (es) 2010-02-26
CO6351799A2 (es) 2011-12-20
MX2011000939A (es) 2011-03-04
ZA201101445B (en) 2012-07-25
AU2009273494A1 (en) 2010-01-28
EP2307439A1 (fr) 2011-04-13
CL2011000153A1 (es) 2011-07-08
DOP2011000024A (es) 2011-02-28
EP2147924A1 (fr) 2010-01-27
PE20110402A1 (es) 2011-06-19
TW201008570A (en) 2010-03-01
SV2011003817A (es) 2011-05-20
IL210314A0 (en) 2011-03-31
US20110190246A1 (en) 2011-08-04

Similar Documents

Publication Publication Date Title
HRP20191049T1 (hr) (11beta, 17beta)-17-hidroksi-11-[4-(metilsulfonil)fenil]-17-(pentalfuorometil)estra-4,9-dien-3-on za uporabu za liječenje bolesti
MY161549A (en) Progesterone antagonists such as cdb-4124 in the treatment of breast cancer
BR0316843A (pt) Derivados tetracìclicos contendo heteroátomo como moduladores seletivos do receptor de estrogênio
MX338290B (es) Tratamiento de enfermedad de alzheimer, perdida de cognición, perdida de memoria y demencia con precursores de esteroides sexuales en conbinación con moduladores selectivos del receptor de estrógenos.
CU20120175A7 (es) Compuestos derivados de 6,7-dihidro-5h-benzo[7]anulenos
MA32477B1 (fr) Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique
DE602005019905D1 (de) -modulatoren
ECSP078043A (es) Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona
BR0215152A (pt) Heterocompostos tetracìclicos como moduladores de receptores de estrogênio
UY29625A1 (es) Uso de moduladores no esteroides de receptores de progesterona
EA200702524A1 (ru) Нестероидные модуляторы рецептора прогестерона
TN2015000454A1 (en) Progesterone receptor antagonist dosage form
TN2011000022A1 (en) Estratriene derivatives comprising heterocyclic bioisosteres for the phenolic a - ring
ATE412631T1 (de) Indolderivate als progesteron-rezeptormodulatoren
CU20110018A7 (es) Derivados de estratrieno que comprenden bioisósteros heterocíclicos para el anillo fenólico a
UY30815A1 (es) Moduladores no esteroidales del receptor de progesterona
TH85615B (th) สารปรับโพรเจสเตอโรนรีเซปเตอร์ชนิดนอนสเตียรอยด์
TH85615A (th) สารปรับโพรเจสเตอโรนรีเซปเตอร์ชนิดนอนสเตียรอยด์
DOP2002000384A (es) Moduladores de receptores estrogenicos.