EA200702524A1 - Нестероидные модуляторы рецептора прогестерона - Google Patents

Нестероидные модуляторы рецептора прогестерона

Info

Publication number
EA200702524A1
EA200702524A1 EA200702524A EA200702524A EA200702524A1 EA 200702524 A1 EA200702524 A1 EA 200702524A1 EA 200702524 A EA200702524 A EA 200702524A EA 200702524 A EA200702524 A EA 200702524A EA 200702524 A1 EA200702524 A1 EA 200702524A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptor modulators
progesterone receptor
nonsteroid
prevention
compounds
Prior art date
Application number
EA200702524A
Other languages
English (en)
Inventor
Александер Хиллиш
Ульрих Боте
Гюнтер Кауфманн
Лотар Зобек
Ульрике Фурманн
Петер Дрёшер
Норберт Шмеес
Вольфганг Шведе
Карстен Мёллер
Аня Шмидт
Original Assignee
Байер Шеринг Фарма Акциенгезельшафт
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер Шеринг Фарма Акциенгезельшафт filed Critical Байер Шеринг Фарма Акциенгезельшафт
Publication of EA200702524A1 publication Critical patent/EA200702524A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Представленное изобретение касается нестероидных модуляторов рецептора прогестерона общей формулы Iспособа их получения, применения модуляторов рецептора прогестерона для получения медикаментов и фармацевтических композиций, содержащих эти соединения. Соединения в соответствии с изобретением пригодны для лечения и профилактики гинекологических расстройств, таких как эндометриоз, леиомиома матки, дисфункциональное кровотечение и дисменорея, и для лечения и профилактики гормонозависимых опухолей и для применения для контроля женской фертильности и для гормонзаместительной терапии.
EA200702524A 2005-06-24 2006-06-22 Нестероидные модуляторы рецептора прогестерона EA200702524A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030292A DE102005030292A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren
PCT/EP2006/006531 WO2006136461A2 (en) 2005-06-24 2006-06-22 Non-steroidal progesterone receptor modulators

Publications (1)

Publication Number Publication Date
EA200702524A1 true EA200702524A1 (ru) 2008-06-30

Family

ID=37199176

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702524A EA200702524A1 (ru) 2005-06-24 2006-06-22 Нестероидные модуляторы рецептора прогестерона

Country Status (22)

Country Link
EP (1) EP1902049A2 (ru)
JP (1) JP2008543910A (ru)
KR (1) KR20080030622A (ru)
CN (1) CN101248066A (ru)
AR (1) AR054519A1 (ru)
AU (1) AU2006261048A1 (ru)
BR (1) BRPI0611903A2 (ru)
CA (1) CA2611897A1 (ru)
CR (1) CR9598A (ru)
DE (1) DE102005030292A1 (ru)
DO (1) DOP2006000148A (ru)
EA (1) EA200702524A1 (ru)
EC (1) ECSP078044A (ru)
GT (1) GT200600271A (ru)
IL (1) IL188021A0 (ru)
MX (1) MX2008000072A (ru)
NO (1) NO20080440L (ru)
PE (1) PE20070125A1 (ru)
TW (1) TW200740778A (ru)
UY (1) UY29624A1 (ru)
WO (1) WO2006136461A2 (ru)
ZA (1) ZA200800690B (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
WO2010002075A1 (en) * 2008-07-02 2010-01-07 Pharmacostech Co., Ltd. Methods for preparing amide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19856475A1 (de) * 1998-11-27 2000-05-31 Schering Ag Nichtsteroidale Entzündungshemmer
EP1344776A1 (en) * 2002-03-11 2003-09-17 Schering Aktiengesellschaft 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders
JP2008529963A (ja) * 2003-07-01 2008-08-07 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト 複素環式−置換されたペンタノール誘導体類、それらの生成方法及び抗炎症剤としてのそれらの使用

Also Published As

Publication number Publication date
ZA200800690B (en) 2009-09-30
DE102005030292A1 (de) 2007-01-11
TW200740778A (en) 2007-11-01
BRPI0611903A2 (pt) 2010-10-05
MX2008000072A (es) 2008-03-24
UY29624A1 (es) 2007-01-31
KR20080030622A (ko) 2008-04-04
CR9598A (es) 2008-04-09
GT200600271A (es) 2007-02-05
WO2006136461A2 (en) 2006-12-28
WO2006136461A3 (en) 2007-03-15
AU2006261048A1 (en) 2006-12-28
IL188021A0 (en) 2008-03-20
CA2611897A1 (en) 2006-12-28
CN101248066A (zh) 2008-08-20
ECSP078044A (es) 2008-01-23
DOP2006000148A (es) 2007-07-15
JP2008543910A (ja) 2008-12-04
PE20070125A1 (es) 2007-02-14
NO20080440L (no) 2008-03-25
EP1902049A2 (en) 2008-03-26
AR054519A1 (es) 2007-06-27

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