ECSP078044A - Moduladores no esteroides de receptor de progesterona - Google Patents

Moduladores no esteroides de receptor de progesterona

Info

Publication number
ECSP078044A
ECSP078044A EC2007008044A ECSP078044A ECSP078044A EC SP078044 A ECSP078044 A EC SP078044A EC 2007008044 A EC2007008044 A EC 2007008044A EC SP078044 A ECSP078044 A EC SP078044A EC SP078044 A ECSP078044 A EC SP078044A
Authority
EC
Ecuador
Prior art keywords
therapy
prevention
receptor modulators
progesterone receptor
steroid progesterone
Prior art date
Application number
EC2007008044A
Other languages
English (en)
Inventor
Alexander Hillisch
Norbert Schmees
Wolfgang Schwede
Peter Droescher
Ulrike Fuhrmann
Carsten Moeller
Anja Schmidt
Ulrich Bothe
Lothar Sobek
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of ECSP078044A publication Critical patent/ECSP078044A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/02—1,2-Oxazines; Hydrogenated 1,2-oxazines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a moduladores no-esteroides de receptor de progesterona de la fórmula general (I), al proceso para su preparación, al uso de los moduladores del receptor de progesterona para la producción de medicamentos así como también composiciones farmacéuticas que contienen estos compuestos. Los compuestos según la invención son apropiados para la terapia y la prevención de enfermedades ginecológicas tales como endometriosis, leiomiomas de útero, hemorragias disfuncionales y dismenorrea y para la terapia y la prevención de tumores dependientes de hormonas y para el uso para el control de la fertilidad femenina y para la terapia de reemplazo hormonal.
EC2007008044A 2005-06-24 2007-12-21 Moduladores no esteroides de receptor de progesterona ECSP078044A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005030292A DE102005030292A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren

Publications (1)

Publication Number Publication Date
ECSP078044A true ECSP078044A (es) 2008-01-23

Family

ID=37199176

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007008044A ECSP078044A (es) 2005-06-24 2007-12-21 Moduladores no esteroides de receptor de progesterona

Country Status (22)

Country Link
EP (1) EP1902049A2 (es)
JP (1) JP2008543910A (es)
KR (1) KR20080030622A (es)
CN (1) CN101248066A (es)
AR (1) AR054519A1 (es)
AU (1) AU2006261048A1 (es)
BR (1) BRPI0611903A2 (es)
CA (1) CA2611897A1 (es)
CR (1) CR9598A (es)
DE (1) DE102005030292A1 (es)
DO (1) DOP2006000148A (es)
EA (1) EA200702524A1 (es)
EC (1) ECSP078044A (es)
GT (1) GT200600271A (es)
IL (1) IL188021A0 (es)
MX (1) MX2008000072A (es)
NO (1) NO20080440L (es)
PE (1) PE20070125A1 (es)
TW (1) TW200740778A (es)
UY (1) UY29624A1 (es)
WO (1) WO2006136461A2 (es)
ZA (1) ZA200800690B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
WO2010002075A1 (en) * 2008-07-02 2010-01-07 Pharmacostech Co., Ltd. Methods for preparing amide derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19856475A1 (de) * 1998-11-27 2000-05-31 Schering Ag Nichtsteroidale Entzündungshemmer
EP1344776A1 (en) * 2002-03-11 2003-09-17 Schering Aktiengesellschaft 5- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -phtalide and 6- 2-hydroxy-3-[1-(3-trifluoromethylphenyl)-cyclopropyl]-propionylamino -4-methyl-2,3-benzoxazin-1-one derivatives with progesterone receptor modulating activity for use in fertility control, hormone replacement therapy and the treatment of gynecological disorders
KR20060027376A (ko) * 2003-07-01 2006-03-27 쉐링 악티엔게젤샤프트 헤테로시클릭 치환된 펜탄올 유도체, 그의 제조 방법 및그의 항염증제로서 용도

Also Published As

Publication number Publication date
IL188021A0 (en) 2008-03-20
ZA200800690B (en) 2009-09-30
PE20070125A1 (es) 2007-02-14
DE102005030292A1 (de) 2007-01-11
CN101248066A (zh) 2008-08-20
UY29624A1 (es) 2007-01-31
WO2006136461A2 (en) 2006-12-28
WO2006136461A3 (en) 2007-03-15
KR20080030622A (ko) 2008-04-04
EP1902049A2 (en) 2008-03-26
TW200740778A (en) 2007-11-01
CR9598A (es) 2008-04-09
JP2008543910A (ja) 2008-12-04
GT200600271A (es) 2007-02-05
BRPI0611903A2 (pt) 2010-10-05
AR054519A1 (es) 2007-06-27
NO20080440L (no) 2008-03-25
AU2006261048A1 (en) 2006-12-28
DOP2006000148A (es) 2007-07-15
MX2008000072A (es) 2008-03-24
CA2611897A1 (en) 2006-12-28
EA200702524A1 (ru) 2008-06-30

Similar Documents

Publication Publication Date Title
AR054586A1 (es) Uso de moduladores del receptor de progesterona
CU20120175A7 (es) Compuestos derivados de 6,7-dihidro-5h-benzo[7]anulenos
DOP2009000148A (es) Derivados de ester y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides
ECSP18047708A (es) Derivados de 17-hidroxi-17-pentafluoroetil-estra-4,9(10)-dien-11-arilo como antagonistas de progesterona y procedimientos para su preparación
ECSP078043A (es) Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona
NI201000090A (es) Agonistas novedosos de los receptores de glucocorticoides.
ECSP099620A (es) Derivados de ciclohexano espirociclico
EA201491096A1 (ru) Производные 6,7-дигидро-5h-бензо[7]аннулена, способ их получения, фармацевтические препараты, которые их содержат, а также их применение для изготовления лекарственных средств
UY29625A1 (es) Uso de moduladores no esteroides de receptores de progesterona
ECSP078044A (es) Moduladores no esteroides de receptor de progesterona
UY30805A1 (es) Moduladores no esteroides de receptores de progesterona
UY30815A1 (es) Moduladores no esteroidales del receptor de progesterona
MA32477B1 (fr) Derives estratrienes comprenant des bioisosteres heterocycliques pour le cycle a phenolique
BR112021011728A8 (pt) Antagonista do receptor de estrogênio
CU20090109A7 (es) Derivados de éster y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides
TH85615A (th) สารปรับโพรเจสเตอโรนรีเซปเตอร์ชนิดนอนสเตียรอยด์