ECSP078043A - Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona - Google Patents

Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona

Info

Publication number
ECSP078043A
ECSP078043A EC2007008043A ECSP078043A ECSP078043A EC SP078043 A ECSP078043 A EC SP078043A EC 2007008043 A EC2007008043 A EC 2007008043A EC SP078043 A ECSP078043 A EC SP078043A EC SP078043 A ECSP078043 A EC SP078043A
Authority
EC
Ecuador
Prior art keywords
benzofurarona
derivatives
therapy
progesterone receptors
prevention
Prior art date
Application number
EC2007008043A
Other languages
English (en)
Inventor
Norbert Schmees
Wolfgang Schwede
Ulrike Fuhrmann
Carsten Moeller
Anja Schmidt
Ulrich Bothe
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of ECSP078043A publication Critical patent/ECSP078043A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Reproductive Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

La presente invención se refiere a moduladores no esteroides del receptor de progesterona de la fórmula general I, al proceso para su producción, al uso de los moduladores del receptor de progesterona para la preparación de agentes farmacéuticos así como también composiciones farmacéuticas que contienen es-tos compuestos. Los compuestos según la invención son apropiados para la terapia y la prevención de enfermedades ginecológicas tales como endometrio-sis, leiomiomas de útero, hemorragias disfuncionales y dismenorrea y para la te-rapia y la prevención de tumores dependientes de hormonas y para el uso para el control de la fertilidad femenina y para la terapia de reemplazo hormonal.
EC2007008043A 2005-06-24 2007-12-21 Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona ECSP078043A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102005030294A DE102005030294A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren

Publications (1)

Publication Number Publication Date
ECSP078043A true ECSP078043A (es) 2008-01-23

Family

ID=36716643

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2007008043A ECSP078043A (es) 2005-06-24 2007-12-21 Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona

Country Status (22)

Country Link
EP (1) EP1899315A1 (es)
JP (1) JP2008543911A (es)
KR (1) KR20080018275A (es)
CN (1) CN101248056A (es)
AR (1) AR057409A1 (es)
AU (1) AU2006261049A1 (es)
BR (1) BRPI0612305A2 (es)
CA (1) CA2611900A1 (es)
CR (1) CR9595A (es)
DE (1) DE102005030294A1 (es)
DO (1) DOP2006000150A (es)
EA (1) EA200702604A1 (es)
EC (1) ECSP078043A (es)
GT (1) GT200600272A (es)
IL (1) IL188022A0 (es)
MX (1) MX2008000070A (es)
NO (1) NO20080441L (es)
PE (1) PE20070170A1 (es)
TW (1) TW200738665A (es)
UY (1) UY29626A1 (es)
WO (1) WO2006136462A1 (es)
ZA (1) ZA200800689B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
ES2701400T3 (es) 2012-05-31 2019-02-22 Repros Therapeutics Inc Formulaciones para la administración vaginal de antiprogestinas
EP2914268B1 (en) 2012-11-02 2018-07-04 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723722A1 (de) * 1997-05-30 1998-12-10 Schering Ag Nichtsteroidale Gestagene
CA2371273A1 (en) * 1999-05-04 2000-11-09 Andrew Fensome Tetracyclic progesterone receptor modulator compounds and methods
US6358948B1 (en) * 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
CA2472746A1 (en) * 2002-01-14 2003-07-24 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof
DK1482925T3 (da) * 2002-03-11 2007-05-14 Bayer Schering Pharma Ag 5- (2-hydroxy-3 -'1 - (3-trifluormethylphenyl) cyclopropylpropionylamino) phtalid og relaterede forbindelser med progesteronreceptormoducerende aktivitet til anvendelse i fertilitetskontrol og hormonerstatningsterapi
DE10346939A1 (de) * 2003-10-06 2005-05-19 Schering Ag Heterocyclisch substituierte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Also Published As

Publication number Publication date
KR20080018275A (ko) 2008-02-27
NO20080441L (no) 2008-03-07
AR057409A1 (es) 2007-12-05
TW200738665A (en) 2007-10-16
AU2006261049A1 (en) 2006-12-28
CA2611900A1 (en) 2006-12-28
EP1899315A1 (en) 2008-03-19
CR9595A (es) 2008-05-05
DE102005030294A1 (de) 2007-01-04
JP2008543911A (ja) 2008-12-04
IL188022A0 (en) 2008-03-20
ZA200800689B (en) 2009-07-29
BRPI0612305A2 (pt) 2010-11-03
DOP2006000150A (es) 2006-12-31
EA200702604A1 (ru) 2008-06-30
PE20070170A1 (es) 2007-03-02
WO2006136462A1 (en) 2006-12-28
UY29626A1 (es) 2007-01-31
GT200600272A (es) 2007-08-20
MX2008000070A (es) 2008-03-19
CN101248056A (zh) 2008-08-20

Similar Documents

Publication Publication Date Title
CU20120175A7 (es) Compuestos derivados de 6,7-dihidro-5h-benzo[7]anulenos
DOP2009000148A (es) Derivados de ester y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides
ECSP18047708A (es) Derivados de 17-hidroxi-17-pentafluoroetil-estra-4,9(10)-dien-11-arilo como antagonistas de progesterona y procedimientos para su preparación
ECSP078043A (es) Derivados de benzofurarona como moduladores no esteroides de receptores de progesterona
SV2010003580A (es) Agonistas novedosos de los receptores de glucocorticoides
ECSP055574A (es) Uso de derivados de tio-oxindol en el tratamiento de condiciones relacionadas con hormonas.
CU20140064A7 (es) Derivados de 6,7- dihidro-5h-benzo[7]anuleno, procesos para su preparación, productos farmacéuticos que comprenden a los mismos y su uso en la preparación de medicamentos
UY29625A1 (es) Uso de moduladores no esteroides de receptores de progesterona
ECSP078044A (es) Moduladores no esteroides de receptor de progesterona
CR9627A (es) Cyanopyrrole-sulfonamide progesterone receptor modulators and uses thereof
UY30805A1 (es) Moduladores no esteroides de receptores de progesterona
SV2011003817A (es) Derivados de estratrieno que comprenden bioisosteros heterociclicos para el anillo fenolico a
UY30815A1 (es) Moduladores no esteroidales del receptor de progesterona
ECSP109872A (es) Estratrienos 8-beta-sustituidos como estrógenos de acción selectiva
CU20090109A7 (es) Derivados de éster y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides
TH85615A (th) สารปรับโพรเจสเตอโรนรีเซปเตอร์ชนิดนอนสเตียรอยด์