ECSP078043A - BENZOFURARONA DERIVATIVES AS NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS - Google Patents
BENZOFURARONA DERIVATIVES AS NON-STEROID MODULATORS OF PROGESTERONE RECEPTORSInfo
- Publication number
- ECSP078043A ECSP078043A EC2007008043A ECSP078043A ECSP078043A EC SP078043 A ECSP078043 A EC SP078043A EC 2007008043 A EC2007008043 A EC 2007008043A EC SP078043 A ECSP078043 A EC SP078043A EC SP078043 A ECSP078043 A EC SP078043A
- Authority
- EC
- Ecuador
- Prior art keywords
- benzofurarona
- derivatives
- therapy
- progesterone receptors
- prevention
- Prior art date
Links
- 102000003998 progesterone receptors Human genes 0.000 title 1
- 108090000468 progesterone receptors Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000002265 prevention Effects 0.000 abstract 2
- 239000002379 progesterone receptor modulator Substances 0.000 abstract 2
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 abstract 2
- 238000002560 therapeutic procedure Methods 0.000 abstract 2
- 208000005171 Dysmenorrhea Diseases 0.000 abstract 1
- 206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
- 201000009273 Endometriosis Diseases 0.000 abstract 1
- 208000032843 Hemorrhage Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 206010046798 Uterine leiomyoma Diseases 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000035558 fertility Effects 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 238000002657 hormone replacement therapy Methods 0.000 abstract 1
- 201000010260 leiomyoma Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
- 201000007954 uterine fibroid Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
- Furan Compounds (AREA)
Abstract
La presente invención se refiere a moduladores no esteroides del receptor de progesterona de la fórmula general I, al proceso para su producción, al uso de los moduladores del receptor de progesterona para la preparación de agentes farmacéuticos así como también composiciones farmacéuticas que contienen es-tos compuestos. Los compuestos según la invención son apropiados para la terapia y la prevención de enfermedades ginecológicas tales como endometrio-sis, leiomiomas de útero, hemorragias disfuncionales y dismenorrea y para la te-rapia y la prevención de tumores dependientes de hormonas y para el uso para el control de la fertilidad femenina y para la terapia de reemplazo hormonal.The present invention relates to non-steroidal progesterone receptor modulators of the general formula I, to the process for their production, to the use of progesterone receptor modulators for the preparation of pharmaceutical agents as well as pharmaceutical compositions containing these compounds. The compounds according to the invention are suitable for the therapy and prevention of gynecological diseases such as endometriosis, uterine leiomyomas, dysfunctional hemorrhages and dysmenorrhea and for the therapy and prevention of hormone-dependent tumors and for use for Female fertility control and for hormone replacement therapy.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005030294A DE102005030294A1 (en) | 2005-06-24 | 2005-06-24 | Nonsteroidal progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ECSP078043A true ECSP078043A (en) | 2008-01-23 |
Family
ID=36716643
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EC2007008043A ECSP078043A (en) | 2005-06-24 | 2007-12-21 | BENZOFURARONA DERIVATIVES AS NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1899315A1 (en) |
| JP (1) | JP2008543911A (en) |
| KR (1) | KR20080018275A (en) |
| CN (1) | CN101248056A (en) |
| AR (1) | AR057409A1 (en) |
| AU (1) | AU2006261049A1 (en) |
| BR (1) | BRPI0612305A2 (en) |
| CA (1) | CA2611900A1 (en) |
| CR (1) | CR9595A (en) |
| DE (1) | DE102005030294A1 (en) |
| DO (1) | DOP2006000150A (en) |
| EA (1) | EA200702604A1 (en) |
| EC (1) | ECSP078043A (en) |
| GT (1) | GT200600272A (en) |
| IL (1) | IL188022A0 (en) |
| MX (1) | MX2008000070A (en) |
| NO (1) | NO20080441L (en) |
| PE (1) | PE20070170A1 (en) |
| TW (1) | TW200738665A (en) |
| UY (1) | UY29626A1 (en) |
| WO (1) | WO2006136462A1 (en) |
| ZA (1) | ZA200800689B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UY30805A1 (en) * | 2006-12-21 | 2008-07-31 | Bayer Schering Pharma Ag | NON-STEROID MODULATORS OF PROGESTERONE RECEPTORS |
| DE102007032800A1 (en) * | 2007-07-10 | 2009-01-15 | Bayer Schering Pharma Aktiengesellschaft | Nonsteroidal progesterone receptor modulators |
| DE102007058747A1 (en) * | 2007-12-05 | 2009-06-10 | Bayer Schering Pharma Aktiengesellschaft | Nonsteroidal progesterone receptor modulators |
| TWI477276B (en) | 2008-04-28 | 2015-03-21 | Repros Therapeutics Inc | Antiprogestin dosing regimens |
| KR102127348B1 (en) | 2012-05-31 | 2020-06-29 | 앨러간 파마슈티컬스 인터내셔널 리미티드 | Formulations and methods for vaginal delivery of antiprogestins |
| HK1211852A1 (en) | 2012-11-02 | 2016-06-03 | Repros Therapeutics Inc. | Methods and compositions for treating progesterone-dependent conditions |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19723722A1 (en) * | 1997-05-30 | 1998-12-10 | Schering Ag | Nonsteroidal progestogens |
| US6358948B1 (en) * | 1999-05-04 | 2002-03-19 | American Home Products Corporation | Quinazolinone and benzoxazine derivatives as progesterone receptor modulators |
| EP1175422A2 (en) * | 1999-05-04 | 2002-01-30 | Ligand Pharmaceuticals Incorporated | Tetracyclic progesterone receptor modulator compounds and methods |
| CA2472746A1 (en) * | 2002-01-14 | 2003-07-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | Glucocorticoid mimetics, methods of making them, pharmaceutical formulations containing them and uses thereof |
| EP1482925B1 (en) * | 2002-03-11 | 2007-01-17 | Schering AG | 5-(2-hydroxy-3-'1-(3-trifluoromethylphenyl)-cyclopropl]-propionylamino)-phtalide and related compounds with progesterone receptor modulating activity for use in fertility control and hormone replacement therapy |
| DE10346939A1 (en) * | 2003-10-06 | 2005-05-19 | Schering Ag | New arylalkanol derivatives used for treating e.g. respiratory diseases, joint diseases, vascular inflammations, skin disorders, kidney and liver diseases and neurological diseases |
-
2005
- 2005-06-24 DE DE102005030294A patent/DE102005030294A1/en not_active Ceased
-
2006
- 2006-06-22 BR BRPI0612305-8A patent/BRPI0612305A2/en not_active Application Discontinuation
- 2006-06-22 CN CNA2006800306699A patent/CN101248056A/en active Pending
- 2006-06-22 JP JP2008517445A patent/JP2008543911A/en active Pending
- 2006-06-22 MX MX2008000070A patent/MX2008000070A/en not_active Application Discontinuation
- 2006-06-22 KR KR1020087001789A patent/KR20080018275A/en not_active Withdrawn
- 2006-06-22 EP EP06762405A patent/EP1899315A1/en not_active Withdrawn
- 2006-06-22 WO PCT/EP2006/006532 patent/WO2006136462A1/en active Application Filing
- 2006-06-22 EA EA200702604A patent/EA200702604A1/en unknown
- 2006-06-22 CA CA002611900A patent/CA2611900A1/en not_active Abandoned
- 2006-06-22 AU AU2006261049A patent/AU2006261049A1/en not_active Abandoned
- 2006-06-23 TW TW095122741A patent/TW200738665A/en unknown
- 2006-06-26 GT GT200600272A patent/GT200600272A/en unknown
- 2006-06-26 UY UY29626A patent/UY29626A1/en not_active Application Discontinuation
- 2006-06-26 DO DO2006000150A patent/DOP2006000150A/en unknown
- 2006-06-26 PE PE2006000732A patent/PE20070170A1/en not_active Application Discontinuation
- 2006-06-27 AR ARP060102752A patent/AR057409A1/en unknown
-
2007
- 2007-12-10 IL IL188022A patent/IL188022A0/en unknown
- 2007-12-14 CR CR9595A patent/CR9595A/en not_active Application Discontinuation
- 2007-12-21 EC EC2007008043A patent/ECSP078043A/en unknown
-
2008
- 2008-01-23 ZA ZA200800689A patent/ZA200800689B/en unknown
- 2008-01-23 NO NO20080441A patent/NO20080441L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA200800689B (en) | 2009-07-29 |
| KR20080018275A (en) | 2008-02-27 |
| CN101248056A (en) | 2008-08-20 |
| MX2008000070A (en) | 2008-03-19 |
| DOP2006000150A (en) | 2006-12-31 |
| WO2006136462A1 (en) | 2006-12-28 |
| EP1899315A1 (en) | 2008-03-19 |
| AU2006261049A1 (en) | 2006-12-28 |
| TW200738665A (en) | 2007-10-16 |
| IL188022A0 (en) | 2008-03-20 |
| DE102005030294A1 (en) | 2007-01-04 |
| AR057409A1 (en) | 2007-12-05 |
| JP2008543911A (en) | 2008-12-04 |
| BRPI0612305A2 (en) | 2010-11-03 |
| GT200600272A (en) | 2007-08-20 |
| CA2611900A1 (en) | 2006-12-28 |
| CR9595A (en) | 2008-05-05 |
| UY29626A1 (en) | 2007-01-31 |
| PE20070170A1 (en) | 2007-03-02 |
| NO20080441L (en) | 2008-03-07 |
| EA200702604A1 (en) | 2008-06-30 |
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