NO20080441L - Benzofuranonderivater som ikke-steroide progesteronreseptormodulatorer - Google Patents

Benzofuranonderivater som ikke-steroide progesteronreseptormodulatorer

Info

Publication number
NO20080441L
NO20080441L NO20080441A NO20080441A NO20080441L NO 20080441 L NO20080441 L NO 20080441L NO 20080441 A NO20080441 A NO 20080441A NO 20080441 A NO20080441 A NO 20080441A NO 20080441 L NO20080441 L NO 20080441L
Authority
NO
Norway
Prior art keywords
receptor modulators
progesterone receptor
addition
therapy
steroidal progesterone
Prior art date
Application number
NO20080441A
Other languages
English (en)
Inventor
Ulrike Fuhrmann
Wolfgang Schwede
Norbert Schmees
Ulrich Bothe
Carsten Moeller
Anja Schmidt
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of NO20080441L publication Critical patent/NO20080441L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Oppfinnelsen vedrører ikke-steroide progesteronreseptormodulatorer med generell formel (I), en fremgangsmåte for deres fremstilling, anvendelsen av progesteronreseptormodulatorer i fremstillingen av farmasøytiske midler i tillegg til farmasøytiske preparater som inneholder disse forbindelsene. Forbindelsene ifølge oppfinnelsen er passende til terapi og profylakse av gynekologiske sykdommer slik som endometriose, leiomyomer i livmoren, feilaktig blødning og dysmenoré, i tillegg til for terapien og profylaksen av hormonavhengige tumorer og til anvendelse i kvinnelig fødselskontroll i tillegg til som hormonerstatningsterapi.
NO20080441A 2005-06-24 2008-01-23 Benzofuranonderivater som ikke-steroide progesteronreseptormodulatorer NO20080441L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005030294A DE102005030294A1 (de) 2005-06-24 2005-06-24 Nichtsteroidale Progesteronrezeptor-Modulatoren
PCT/EP2006/006532 WO2006136462A1 (en) 2005-06-24 2006-06-22 Benzofuranone derivatives as nonsteroidal progesterone receptor modulators

Publications (1)

Publication Number Publication Date
NO20080441L true NO20080441L (no) 2008-03-07

Family

ID=36716643

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080441A NO20080441L (no) 2005-06-24 2008-01-23 Benzofuranonderivater som ikke-steroide progesteronreseptormodulatorer

Country Status (22)

Country Link
EP (1) EP1899315A1 (no)
JP (1) JP2008543911A (no)
KR (1) KR20080018275A (no)
CN (1) CN101248056A (no)
AR (1) AR057409A1 (no)
AU (1) AU2006261049A1 (no)
BR (1) BRPI0612305A2 (no)
CA (1) CA2611900A1 (no)
CR (1) CR9595A (no)
DE (1) DE102005030294A1 (no)
DO (1) DOP2006000150A (no)
EA (1) EA200702604A1 (no)
EC (1) ECSP078043A (no)
GT (1) GT200600272A (no)
IL (1) IL188022A0 (no)
MX (1) MX2008000070A (no)
NO (1) NO20080441L (no)
PE (1) PE20070170A1 (no)
TW (1) TW200738665A (no)
UY (1) UY29626A1 (no)
WO (1) WO2006136462A1 (no)
ZA (1) ZA200800689B (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30805A1 (es) * 2006-12-21 2008-07-31 Bayer Schering Pharma Ag Moduladores no esteroides de receptores de progesterona
DE102007032800A1 (de) * 2007-07-10 2009-01-15 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
DE102007058747A1 (de) 2007-12-05 2009-06-10 Bayer Schering Pharma Aktiengesellschaft Nichtsteroidale Progesteronrezeptor-Modulatoren
TWI477276B (zh) * 2008-04-28 2015-03-21 Repros Therapeutics Inc 抗黃體素給藥方案
IN2014DN10548A (no) 2012-05-31 2015-08-21 Repros Therapeutics Inc
US9545411B2 (en) 2012-11-02 2017-01-17 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19723722A1 (de) * 1997-05-30 1998-12-10 Schering Ag Nichtsteroidale Gestagene
US6358948B1 (en) * 1999-05-04 2002-03-19 American Home Products Corporation Quinazolinone and benzoxazine derivatives as progesterone receptor modulators
CA2371273A1 (en) * 1999-05-04 2000-11-09 Andrew Fensome Tetracyclic progesterone receptor modulator compounds and methods
ATE346058T1 (de) * 2002-01-14 2006-12-15 Boehringer Ingelheim Pharma Glucocorticoid mimetika, verfahren zu ihrer herstellung, pharmazeutische formulierungen sie enthaltend und verwendungen davon
AU2003209720A1 (en) * 2002-03-11 2003-09-22 Schering Ag 5-{2-hydroxy-3-'1-(3-trifluoromethylphenyl)-cyclopropyl!-propionylamino}-phtalide and related compounds with progesterone receptor modulating activity for use in fertility control and hormone replacement therapy
DE10346939A1 (de) * 2003-10-06 2005-05-19 Schering Ag Heterocyclisch substituierte Pentanole, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer

Also Published As

Publication number Publication date
CR9595A (es) 2008-05-05
JP2008543911A (ja) 2008-12-04
CN101248056A (zh) 2008-08-20
DE102005030294A1 (de) 2007-01-04
MX2008000070A (es) 2008-03-19
WO2006136462A1 (en) 2006-12-28
KR20080018275A (ko) 2008-02-27
GT200600272A (es) 2007-08-20
ZA200800689B (en) 2009-07-29
ECSP078043A (es) 2008-01-23
AU2006261049A1 (en) 2006-12-28
PE20070170A1 (es) 2007-03-02
EA200702604A1 (ru) 2008-06-30
DOP2006000150A (es) 2006-12-31
EP1899315A1 (en) 2008-03-19
TW200738665A (en) 2007-10-16
CA2611900A1 (en) 2006-12-28
AR057409A1 (es) 2007-12-05
UY29626A1 (es) 2007-01-31
IL188022A0 (en) 2008-03-20
BRPI0612305A2 (pt) 2010-11-03

Similar Documents

Publication Publication Date Title
NO20090628L (no) Pyridizinon derivativater
NO20080441L (no) Benzofuranonderivater som ikke-steroide progesteronreseptormodulatorer
BRPI0506721A (pt) composto ou um sal de adição de ácido do mesmo
BRPI0517263A (pt) novos derivados de sulfonamida como moduladores do receptor de glicocorticóide para o tratamento de doenças inflamatórias
NO20083427L (no) Cystoksiske midler omfattende nye tomaymycinderivater og deres terapeutiske anvendelse
NO20082445L (no) Neuropeptid-2 reseptor-agonister
EA201070167A1 (ru) Замещенные производные индазола, активные как ингибиторы киназы
NO20066055L (no) Pyridinderivater
NO20082124L (no) Bifenyloksyeddiksyrederivater for behandling av respiratorisk sykdom
TW200637874A (en) Peptides with neuropeptide-2 receptor (Y2R) agonist activity
BRPI0511466A (pt) agonistas peptìdicos do receptor de vasopressina
NO20070570L (no) Forbindelser.
NO20090266L (no) Piperazinylderivater anvendelige i behandlingen av GPR38 receptormedierte sykdommer
NO20080394L (no) N-(arylalkyl)-1H-pyrrolopyridin-2-karboksamidderivater, fremstilling og anvendelse derav
NO20045217L (no) Anvendelse av tio-oxindolderivater for behandling av hormon relaterte tilstander
NO20080440L (no) Ikke-steroide progesteronreseptormodulatorer
MY157425A (en) Substituted oxindole derivatives and the use thereof for the treatment of vasopressin-dependent illnesses
DK1525215T3 (da) Modulatorer for receptoren for progesteron med forhöjet anti-gonadotrop aktivitet til fertilitetskontrol hos kvinder og ved terapi til erstatning af hormoner
NO20080354L (no) Benzofuranylderivater som 5-HT6-reseptorinhibitorer
UA92500C2 (ru) Цианопирролсульфонамидные модуляторы прогестеронового рецептора и их применение
UY29625A1 (es) Uso de moduladores no esteroides de receptores de progesterona
WO2008113851A3 (en) Novel c11 modified retrosteroids as progesterone receptor modulator compounds
DK2200980T3 (da) Aminoarylsulfonamidforbindelser og deres anvendelse som 5-HT6-ligander
NO20081195L (no) Imidazopyridinderivater som kannabinoidreceptorligander
BRPI0515484A (pt) derivados piridìnicos de indolin-2-ona, o respectivo preparo e a respectiva aplicação em terapêutica

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application