BRPI0515484A - derivados piridìnicos de indolin-2-ona, o respectivo preparo e a respectiva aplicação em terapêutica - Google Patents
derivados piridìnicos de indolin-2-ona, o respectivo preparo e a respectiva aplicação em terapêuticaInfo
- Publication number
- BRPI0515484A BRPI0515484A BRPI0515484-7A BRPI0515484A BRPI0515484A BR PI0515484 A BRPI0515484 A BR PI0515484A BR PI0515484 A BRPI0515484 A BR PI0515484A BR PI0515484 A BRPI0515484 A BR PI0515484A
- Authority
- BR
- Brazil
- Prior art keywords
- indolin
- therapeutic
- preparation
- application
- pyridine derivatives
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
DERIVADOS PIRIDìNICOS DE INDOLIN-2-ONA, O RESPECTIVO PREPARO E RESPECTIVA APLICAçãO EM TERAPêUTICA. A presente invenção refere-se aos derivados de indolin-2-ona, de fórmula geral (I): (I) na qual: R~ 0~, R~ 1~, R~ 2~ e R~ 4~ representam independentemente um do outro um H, (C~ 1~-C~ 6~)alquila; - Z representa um oxigênio, um grupo (CrC6)alquila, tetrahidrofuranila ou tetrahidropiranila, esses grupos sendo eventualmente substituídos; - B representa um grupo T-W, no qual T representa um grupo, -(CH2)m- e W representa um grupo -CONR~ 6~R~ 7¬ou um grupo -NR~ 8~COR~ 9~; no estado de gase ou de sal farmaceuticamente aceitável, no estado de hidrato ou de solvato, assim como seus enantiómeros, diastereoisómero s e suas misturas. Processo de preparo e aplicação em terapêutica.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0409906A FR2875499B1 (fr) | 2004-09-20 | 2004-09-20 | Nouveaux derives pyridiniques d'indolin-2-one, leur preparation et leur application en therapeutique |
PCT/FR2005/002316 WO2006032771A1 (fr) | 2004-09-20 | 2005-09-19 | Derives pyridiniques d ' indolin-2-one , leur preparation et leur application en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0515484A true BRPI0515484A (pt) | 2008-07-22 |
Family
ID=34950710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0515484-7A BRPI0515484A (pt) | 2004-09-20 | 2005-09-19 | derivados piridìnicos de indolin-2-ona, o respectivo preparo e a respectiva aplicação em terapêutica |
Country Status (20)
Country | Link |
---|---|
US (1) | US7488743B2 (pt) |
EP (1) | EP1793834B1 (pt) |
JP (1) | JP2008513422A (pt) |
KR (1) | KR20070054207A (pt) |
CN (1) | CN101022813A (pt) |
AT (1) | ATE412416T1 (pt) |
AU (1) | AU2005286405A1 (pt) |
BR (1) | BRPI0515484A (pt) |
CA (1) | CA2576982A1 (pt) |
CR (2) | CR8955A (pt) |
DE (1) | DE602005010725D1 (pt) |
EA (1) | EA200700692A1 (pt) |
EC (1) | ECSP077307A (pt) |
FR (1) | FR2875499B1 (pt) |
IL (1) | IL181666A0 (pt) |
MA (1) | MA28930B1 (pt) |
MX (1) | MX2007003159A (pt) |
NI (1) | NI200700076A (pt) |
TN (1) | TNSN07052A1 (pt) |
WO (1) | WO2006032771A1 (pt) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2909668B1 (fr) * | 2006-12-12 | 2009-01-23 | Sanofi Aventis Sa | Derives de 5-alkyloxy-indolin-2-one,leur preparation et leurs applications en therapeutique |
CR20160562A (es) * | 2014-06-06 | 2017-01-06 | Hoffmann La Roche | Péptidos como agonistas de la oxitocina |
WO2020016429A1 (en) * | 2018-07-19 | 2020-01-23 | Kemira Oyj | Cellulose composition |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3529994A1 (de) * | 1985-08-22 | 1987-02-26 | Hoechst Ag | Indolinonderivate, verfahren zu ihrer herstellung, sie enthaltende arzneimittel und deren verwendung |
FR2708605A1 (fr) * | 1993-07-30 | 1995-02-10 | Sanofi Sa | Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant. |
FR2714378B1 (fr) | 1993-12-24 | 1996-03-15 | Sanofi Sa | Dérivés de l'indol-2-one substitués en 3 par un groupe azoté, leur préparation, les compositions pharmaceutiques en contenant. |
FR2807038B1 (fr) | 2000-04-03 | 2002-08-16 | Sanofi Synthelabo | Nouveaux derives d'indolin-2-one, leur preparation et les compositions pharmaceutiques les contenant |
-
2004
- 2004-09-20 FR FR0409906A patent/FR2875499B1/fr not_active Expired - Fee Related
-
2005
- 2005-09-19 AU AU2005286405A patent/AU2005286405A1/en not_active Abandoned
- 2005-09-19 AT AT05805779T patent/ATE412416T1/de not_active IP Right Cessation
- 2005-09-19 KR KR1020077006263A patent/KR20070054207A/ko not_active Application Discontinuation
- 2005-09-19 CA CA002576982A patent/CA2576982A1/fr not_active Abandoned
- 2005-09-19 CN CNA2005800311620A patent/CN101022813A/zh active Pending
- 2005-09-19 BR BRPI0515484-7A patent/BRPI0515484A/pt not_active IP Right Cessation
- 2005-09-19 EP EP05805779A patent/EP1793834B1/fr active Active
- 2005-09-19 MX MX2007003159A patent/MX2007003159A/es not_active Application Discontinuation
- 2005-09-19 EA EA200700692A patent/EA200700692A1/ru unknown
- 2005-09-19 JP JP2007531801A patent/JP2008513422A/ja active Pending
- 2005-09-19 DE DE602005010725T patent/DE602005010725D1/de active Active
- 2005-09-19 WO PCT/FR2005/002316 patent/WO2006032771A1/fr active Application Filing
-
2007
- 2007-02-12 TN TNP2007000052A patent/TNSN07052A1/fr unknown
- 2007-03-01 IL IL181666A patent/IL181666A0/en unknown
- 2007-03-05 CR CR8955A patent/CR8955A/es not_active Application Discontinuation
- 2007-03-07 CR CR8981A patent/CR8981A/es not_active Application Discontinuation
- 2007-03-08 EC EC2007007307A patent/ECSP077307A/es unknown
- 2007-03-15 NI NI200700076A patent/NI200700076A/es unknown
- 2007-03-16 US US11/686,977 patent/US7488743B2/en active Active
- 2007-04-11 MA MA29824A patent/MA28930B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EP1793834A1 (fr) | 2007-06-13 |
EA200700692A1 (ru) | 2007-08-31 |
TNSN07052A1 (fr) | 2008-06-02 |
MA28930B1 (fr) | 2007-10-01 |
JP2008513422A (ja) | 2008-05-01 |
ECSP077307A (es) | 2007-04-26 |
NI200700076A (es) | 2008-03-07 |
CN101022813A (zh) | 2007-08-22 |
AU2005286405A1 (en) | 2006-03-30 |
DE602005010725D1 (de) | 2008-12-11 |
WO2006032771A1 (fr) | 2006-03-30 |
FR2875499A1 (fr) | 2006-03-24 |
EP1793834B1 (fr) | 2008-10-29 |
CA2576982A1 (fr) | 2006-03-30 |
MX2007003159A (es) | 2007-05-16 |
US7488743B2 (en) | 2009-02-10 |
IL181666A0 (en) | 2007-07-04 |
FR2875499B1 (fr) | 2006-10-27 |
US20070185166A1 (en) | 2007-08-09 |
CR8955A (es) | 2007-08-28 |
KR20070054207A (ko) | 2007-05-28 |
ATE412416T1 (de) | 2008-11-15 |
CR8981A (es) | 2007-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |