CR20160562A - Péptidos como agonistas de la oxitocina - Google Patents

Péptidos como agonistas de la oxitocina

Info

Publication number
CR20160562A
CR20160562A CR20160562A CR20160562A CR20160562A CR 20160562 A CR20160562 A CR 20160562A CR 20160562 A CR20160562 A CR 20160562A CR 20160562 A CR20160562 A CR 20160562A CR 20160562 A CR20160562 A CR 20160562A
Authority
CR
Costa Rica
Prior art keywords
oxychocine
agonists
peptides
lower alkyl
cycloalkyl
Prior art date
Application number
CR20160562A
Other languages
English (en)
Inventor
Goutam Saha
Caterina Bissantz
Christophe Grundschober
Konrad Bleicher
Kanchan Chakraborty
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20160562A publication Critical patent/CR20160562A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La invención se refiere a compuestos de fórmula en donde R1 es hidrógeno, alquilo inferior, -CH2-cicloalquilo o cicloalquilo; R2 es hidrógeno, alquilo inferior, alquilo inferior sustituido con hidroxi, o R1 y R2 pueden formar junto con el átomo de N y C al que están unidos un anillo de pirrolidina opcionalmente sustituido con uno o dos átomos de F o con hidroxi, o puede formar una azetidina o un anillo de piperidina;
CR20160562A 2014-06-06 2014-06-06 Péptidos como agonistas de la oxitocina CR20160562A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14171440 2014-06-06
PCT/EP2015/062314 WO2015185584A1 (en) 2014-06-06 2015-06-03 Peptides as oxytocin agonists

Publications (1)

Publication Number Publication Date
CR20160562A true CR20160562A (es) 2017-01-06

Family

ID=50932985

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160562A CR20160562A (es) 2014-06-06 2014-06-06 Péptidos como agonistas de la oxitocina

Country Status (16)

Country Link
US (1) US20170081368A1 (es)
EP (1) EP3152225B1 (es)
JP (1) JP6535688B2 (es)
KR (1) KR20170004014A (es)
CN (1) CN106459156A (es)
AU (1) AU2015270564A1 (es)
CA (1) CA2950493A1 (es)
CL (1) CL2016003076A1 (es)
CR (1) CR20160562A (es)
EA (1) EA030296B1 (es)
IL (1) IL248625A0 (es)
MX (1) MX2016015877A (es)
PE (1) PE20170427A1 (es)
PH (1) PH12016502251A1 (es)
SG (1) SG11201610221WA (es)
WO (1) WO2015185584A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS65144B1 (sr) 2014-09-19 2024-02-29 Ferring Bv Postupak za lečenje prader-vilijevog sindroma
US20190135859A1 (en) 2017-08-11 2019-05-09 Ferring B.V. Method of manufacturing a pharmaceutical composition
CN110997697A (zh) 2017-08-11 2020-04-10 辉凌公司 制备药物组合物的方法
AU2019345313A1 (en) 2018-09-20 2021-03-18 Levo Therapeutics, Inc. Carbetocin drug product and process for preparing same
US20200093884A1 (en) 2018-09-20 2020-03-26 Mark C. Manning Stable intranasal formulations of carbetocin
CN113801200B (zh) * 2021-09-28 2023-07-25 浙江湃肽生物有限公司 一种卡贝缩宫素的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483794A (en) * 1983-05-10 1984-11-20 Ceskoslovenska Akademie Ved Analogs of neurohypophysial hormones
KR20070022753A (ko) * 2004-05-26 2007-02-27 화이자 인코포레이티드 인다졸 및 인돌론 유도체 및 이의 약제로서의 용도
FR2875499B1 (fr) * 2004-09-20 2006-10-27 Sanofi Aventis Sa Nouveaux derives pyridiniques d'indolin-2-one, leur preparation et leur application en therapeutique
CN101641013B (zh) * 2007-01-22 2014-07-30 Gtx公司 核受体结合剂
CA2718148C (en) * 2008-03-31 2017-11-07 Ferring B.V. Oxytocin analogues
BRPI0919342A2 (pt) * 2008-09-23 2015-12-29 Hoffmann La Roche derivados do isoxazol [4,5] piridin-3-il-piperazina, seu processo de preparação, seu medicamento e seu uso
KR101701533B1 (ko) * 2009-05-05 2017-02-13 에프. 호프만-라 로슈 아게 아이속사졸-피리다진 유도체
TWI463990B (zh) * 2009-09-21 2014-12-11 Ferring Bv 催產素受體促進劑
ES2509270T3 (es) * 2009-10-01 2014-10-17 The University Of Sydney Terapia y prevención del alcoholismo
US9585935B2 (en) 2010-07-30 2017-03-07 The Regents Of The University Of California Intranasal oxytocin treatment to improve schizophrenia

Also Published As

Publication number Publication date
EP3152225A1 (en) 2017-04-12
JP2017518313A (ja) 2017-07-06
CA2950493A1 (en) 2015-12-10
SG11201610221WA (en) 2017-01-27
IL248625A0 (en) 2017-01-31
WO2015185584A1 (en) 2015-12-10
JP6535688B2 (ja) 2019-06-26
MX2016015877A (es) 2017-03-27
EA201692488A1 (ru) 2017-05-31
CN106459156A (zh) 2017-02-22
AU2015270564A1 (en) 2016-11-17
PH12016502251A1 (en) 2017-02-06
US20170081368A1 (en) 2017-03-23
KR20170004014A (ko) 2017-01-10
EP3152225B1 (en) 2018-11-14
CL2016003076A1 (es) 2017-08-11
EA030296B1 (ru) 2018-07-31
PE20170427A1 (es) 2017-04-26

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