CR20160198A - Derivados de etinilo-imidazolidín-2, 4-diona como moduladore mglur4 - Google Patents
Derivados de etinilo-imidazolidín-2, 4-diona como moduladore mglur4Info
- Publication number
- CR20160198A CR20160198A CR20160198A CR20160198A CR20160198A CR 20160198 A CR20160198 A CR 20160198A CR 20160198 A CR20160198 A CR 20160198A CR 20160198 A CR20160198 A CR 20160198A CR 20160198 A CR20160198 A CR 20160198A
- Authority
- CR
- Costa Rica
- Prior art keywords
- ethylil
- diona
- mglur4
- imidazolidin
- modulator
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4188—1,3-Diazoles condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B55/00—Racemisation; Complete or partial inversion
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se refiere a compuestos de fórmula I: en la que: Y es C-R1',R1' es hidrógeno o halógeno, R1 es hidrógeno o halógeno, R2 es hidrógeno, alquilo inferior o fenilo, R4 es hidrógeno o alquilo inferior, o R2 y R4 pueden formar conjuntamente con los átomos correspondientes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP14150700 | 2014-01-10 | ||
PCT/EP2015/050127 WO2015104271A1 (en) | 2014-01-10 | 2015-01-07 | Ethynyl-imidazolin-2,4-dione derivatives as mglur4 modulators |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20160198A true CR20160198A (es) | 2016-06-17 |
Family
ID=49917002
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20160198A CR20160198A (es) | 2014-01-10 | 2016-04-28 | Derivados de etinilo-imidazolidín-2, 4-diona como moduladore mglur4 |
Country Status (22)
Country | Link |
---|---|
US (1) | US9695128B2 (es) |
EP (1) | EP3092219B1 (es) |
JP (1) | JP6263633B2 (es) |
KR (1) | KR101868248B1 (es) |
CN (1) | CN106170479B (es) |
AR (1) | AR099047A1 (es) |
AU (1) | AU2015205661B2 (es) |
BR (1) | BR112016010168A2 (es) |
CA (1) | CA2934768A1 (es) |
CL (1) | CL2016001739A1 (es) |
CR (1) | CR20160198A (es) |
EA (1) | EA029967B1 (es) |
HK (1) | HK1226054A1 (es) |
IL (1) | IL245327B (es) |
MX (1) | MX369820B (es) |
PE (1) | PE20160860A1 (es) |
PH (1) | PH12016501100B1 (es) |
SG (1) | SG11201605557TA (es) |
TW (1) | TWI649310B (es) |
UA (1) | UA119053C2 (es) |
WO (1) | WO2015104271A1 (es) |
ZA (1) | ZA201602890B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CR20160384A (es) * | 2014-02-25 | 2016-11-07 | Hoffmann La Roche | Derivados de etilino |
LT3322701T (lt) | 2015-07-15 | 2019-07-10 | F. Hoffmann-La Roche Ag | Etinilo dariniai kaip metabotropinių glutamato receptorių moduliatoriai |
AR105556A1 (es) * | 2015-08-03 | 2017-10-18 | Hoffmann La Roche | Derivados de etinilo |
DK3484889T3 (da) | 2016-07-18 | 2020-10-26 | Hoffmann La Roche | Ethynylderivater |
CN111032659B (zh) * | 2017-08-17 | 2022-09-09 | 豪夫迈·罗氏有限公司 | 用于治疗诸如帕金森病的疾病的咪唑并[1,2-a]咪唑-2-酮衍生物 |
US10893929B2 (en) | 2018-01-10 | 2021-01-19 | Cook Medical Technologies Llc | Vascular graft with compartments for compliance matching |
US10517713B2 (en) | 2018-01-10 | 2019-12-31 | Cook Medical Technologies Llc | Vascular graft with helical flow compliance compartments |
EP3827001A1 (en) | 2018-07-26 | 2021-06-02 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SG185285A1 (en) * | 2007-06-03 | 2012-11-29 | Univ Vanderbilt | Benzamide mglur5 positive allosteric modulators and methods of making and using same |
EP2473055A4 (en) * | 2009-09-04 | 2013-02-13 | Univ Vanderbilt | ALLOSTERIC MGLUR4 POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTIONS |
US8420661B2 (en) * | 2010-04-13 | 2013-04-16 | Hoffmann-La Roche Inc. | Arylethynyl derivatives |
CA2837312A1 (en) * | 2011-05-26 | 2012-11-29 | Sunovion Pharmaceuticals Inc. | Metabotropic glutamate receptor 5 allosteric modulators and methods of use thereof |
-
2015
- 2015-01-06 TW TW104100333A patent/TWI649310B/zh not_active IP Right Cessation
- 2015-01-07 EA EA201691046A patent/EA029967B1/ru not_active IP Right Cessation
- 2015-01-07 KR KR1020167018069A patent/KR101868248B1/ko active IP Right Grant
- 2015-01-07 EP EP15700850.9A patent/EP3092219B1/en active Active
- 2015-01-07 CA CA2934768A patent/CA2934768A1/en not_active Abandoned
- 2015-01-07 PE PE2016000958A patent/PE20160860A1/es unknown
- 2015-01-07 WO PCT/EP2015/050127 patent/WO2015104271A1/en active Application Filing
- 2015-01-07 SG SG11201605557TA patent/SG11201605557TA/en unknown
- 2015-01-07 JP JP2016545871A patent/JP6263633B2/ja active Active
- 2015-01-07 BR BR112016010168A patent/BR112016010168A2/pt not_active IP Right Cessation
- 2015-01-07 MX MX2016008887A patent/MX369820B/es active IP Right Grant
- 2015-01-07 AU AU2015205661A patent/AU2015205661B2/en not_active Ceased
- 2015-01-07 CN CN201580002922.9A patent/CN106170479B/zh active Active
- 2015-01-08 AR ARP150100038A patent/AR099047A1/es unknown
- 2015-07-01 UA UAA201608260A patent/UA119053C2/uk unknown
-
2016
- 2016-04-27 IL IL245327A patent/IL245327B/en active IP Right Grant
- 2016-04-28 ZA ZA2016/02890A patent/ZA201602890B/en unknown
- 2016-04-28 CR CR20160198A patent/CR20160198A/es unknown
- 2016-06-09 PH PH12016501100A patent/PH12016501100B1/en unknown
- 2016-07-07 CL CL2016001739A patent/CL2016001739A1/es unknown
- 2016-07-08 US US15/205,466 patent/US9695128B2/en active Active
- 2016-12-14 HK HK16114239A patent/HK1226054A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
BR112016010168A2 (pt) | 2017-08-08 |
KR101868248B1 (ko) | 2018-06-15 |
PE20160860A1 (es) | 2016-09-03 |
EA029967B1 (ru) | 2018-06-29 |
US20170008854A1 (en) | 2017-01-12 |
JP2017502066A (ja) | 2017-01-19 |
WO2015104271A1 (en) | 2015-07-16 |
AR099047A1 (es) | 2016-06-22 |
EP3092219B1 (en) | 2018-09-19 |
MX369820B (es) | 2019-11-22 |
EP3092219A1 (en) | 2016-11-16 |
ZA201602890B (en) | 2017-07-26 |
US9695128B2 (en) | 2017-07-04 |
CA2934768A1 (en) | 2015-07-16 |
CN106170479B (zh) | 2019-02-12 |
MX2016008887A (es) | 2016-10-04 |
AU2015205661B2 (en) | 2018-08-23 |
PH12016501100A1 (en) | 2016-07-11 |
UA119053C2 (uk) | 2019-04-25 |
KR20160095099A (ko) | 2016-08-10 |
JP6263633B2 (ja) | 2018-01-17 |
TWI649310B (zh) | 2019-02-01 |
TW201531464A (zh) | 2015-08-16 |
IL245327A0 (en) | 2016-06-30 |
CN106170479A (zh) | 2016-11-30 |
PH12016501100B1 (en) | 2016-07-11 |
EA201691046A1 (ru) | 2016-12-30 |
CL2016001739A1 (es) | 2017-05-12 |
IL245327B (en) | 2018-12-31 |
HK1226054A1 (zh) | 2017-09-22 |
SG11201605557TA (en) | 2016-08-30 |
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