EA201691046A1 - Производные этинилимидазолин-2,4-диона в качестве модуляторов метаботропного глутаматного рецептора 4 (mglur4) - Google Patents

Производные этинилимидазолин-2,4-диона в качестве модуляторов метаботропного глутаматного рецептора 4 (mglur4)

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Publication number
EA201691046A1
EA201691046A1 EA201691046A EA201691046A EA201691046A1 EA 201691046 A1 EA201691046 A1 EA 201691046A1 EA 201691046 A EA201691046 A EA 201691046A EA 201691046 A EA201691046 A EA 201691046A EA 201691046 A1 EA201691046 A1 EA 201691046A1
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Prior art keywords
hydrogen
lower alkyl
ethylimidazoline
mglur4
dion
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EA201691046A
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English (en)
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EA029967B1 (ru
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Барбара Биманс
Вольфганг Губа
Георг Ешке
Антонио Риччи
Даниэль Рюхер
Эрик Виейра
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Ф. Хоффманн-Ля Рош Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49917002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201691046(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201691046A1 publication Critical patent/EA201691046A1/ru
Publication of EA029967B1 publication Critical patent/EA029967B1/ru

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    • C07D233/72—Two oxygen atoms, e.g. hydantoin
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Настоящее изобретение относится к соединениям формулы Iгде Y представляет собой C-R; Rявляется водородом или галогеном; Rявляется водородом или галогеном; Rявляется водородом, низшим алкилом или фенилом; Rявляется водородом или низшим алкилом; или Rи Rмогут образовывать вместе с соответствующими атомами, к которым они присоединены, следующие кольцаRявляется водородом или низшим алкилом; и если Rи Rобразуют кольцо, такое как описано выше, то Rявляется водородом; или Rи Rвместе с атомом углерода, к которому они присоединены, могут образовывать гетероциклоалкильное кольцо; Rявляется фенилом или пиридинилом, где атом N пиридинильной группы может находиться в разных положениях; или к их фармацевтически приемлемой соли или соли присоединения кислоты, к рацемической смеси или ее соответствующему энантиомеру, и/или оптическому изомеру, и/или стереоизомеру. Соединения могут применяться для лечения болезни Паркинсона, тревожного расстройства, тошноты и рвоты, обессивно-компульсивного расстройства, аутизма, при нейропротекции, лечении онкологического заболевания, депрессивного синдрома и диабета 2 типа.
EA201691046A 2014-01-10 2015-01-07 Производные этинилимидазолин-2,4-диона в качестве модуляторов метаботропного глутаматного рецептора 4 (mglur4) EA029967B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14150700 2014-01-10
PCT/EP2015/050127 WO2015104271A1 (en) 2014-01-10 2015-01-07 Ethynyl-imidazolin-2,4-dione derivatives as mglur4 modulators

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EA201691046A1 true EA201691046A1 (ru) 2016-12-30
EA029967B1 EA029967B1 (ru) 2018-06-29

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US (1) US9695128B2 (ru)
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KR (1) KR101868248B1 (ru)
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AR (1) AR099047A1 (ru)
AU (1) AU2015205661B2 (ru)
BR (1) BR112016010168A2 (ru)
CA (1) CA2934768A1 (ru)
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CR (1) CR20160198A (ru)
EA (1) EA029967B1 (ru)
HK (1) HK1226054A1 (ru)
IL (1) IL245327B (ru)
MX (1) MX369820B (ru)
PE (1) PE20160860A1 (ru)
PH (1) PH12016501100A1 (ru)
SG (1) SG11201605557TA (ru)
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UA (1) UA119053C2 (ru)
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Publication number Priority date Publication date Assignee Title
SI3110802T1 (sl) * 2014-02-25 2019-01-31 F. Hoffmann-La Roche Ag Derivati etinila
RS58929B1 (sr) 2015-07-15 2019-08-30 Hoffmann La Roche Derivati etinila kao modulatori metabotropnih glutamatnih receptora
AR105556A1 (es) * 2015-08-03 2017-10-18 Hoffmann La Roche Derivados de etinilo
RU2745068C2 (ru) 2016-07-18 2021-03-18 Ф. Хоффманн-Ля Рош Аг Производные этинила
JP7364553B2 (ja) * 2017-08-17 2023-10-18 エフ． ホフマン－ラ ロシュ アーゲー パーキンソン病等の疾患を処置するためのイミダゾ［１，２－ａ］イミダゾール－２－オン誘導体
US10893929B2 (en) 2018-01-10 2021-01-19 Cook Medical Technologies Llc Vascular graft with compartments for compliance matching
US10517713B2 (en) 2018-01-10 2019-12-31 Cook Medical Technologies Llc Vascular graft with helical flow compliance compartments
AU2019309448A1 (en) 2018-07-26 2021-01-14 Domain Therapeutics Substituted quinazolinone derivatives and their use as positive allosteric modulators of mGluR4

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MX2009013169A (es) * 2007-06-03 2010-04-30 Univ Vanderbilt Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos.
CN102740699A (zh) * 2009-09-04 2012-10-17 范德比尔特大学 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
US10533000B2 (en) * 2011-05-26 2020-01-14 Sunovion Pharmaceuticals, Inc. Metabotrophic glutamate receptor 5 modulators and methods of use thereof

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AR099047A1 (es) 2016-06-22
ZA201602890B (en) 2017-07-26
US20170008854A1 (en) 2017-01-12
SG11201605557TA (en) 2016-08-30
PH12016501100B1 (en) 2016-07-11
CL2016001739A1 (es) 2017-05-12
TWI649310B (zh) 2019-02-01
MX2016008887A (es) 2016-10-04
MX369820B (es) 2019-11-22
EP3092219B1 (en) 2018-09-19
AU2015205661B2 (en) 2018-08-23
UA119053C2 (uk) 2019-04-25
CR20160198A (es) 2016-06-17
HK1226054A1 (zh) 2017-09-22
KR101868248B1 (ko) 2018-06-15
IL245327A0 (en) 2016-06-30
CA2934768A1 (en) 2015-07-16
US9695128B2 (en) 2017-07-04
JP2017502066A (ja) 2017-01-19
IL245327B (en) 2018-12-31
KR20160095099A (ko) 2016-08-10
TW201531464A (zh) 2015-08-16
BR112016010168A2 (pt) 2017-08-08
CN106170479B (zh) 2019-02-12
EA029967B1 (ru) 2018-06-29
JP6263633B2 (ja) 2018-01-17
PH12016501100A1 (en) 2016-07-11
CN106170479A (zh) 2016-11-30
EP3092219A1 (en) 2016-11-16
WO2015104271A1 (en) 2015-07-16

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