EA201691046A1 - Производные этинилимидазолин-2,4-диона в качестве модуляторов метаботропного глутаматного рецептора 4 (mglur4) - Google Patents

Производные этинилимидазолин-2,4-диона в качестве модуляторов метаботропного глутаматного рецептора 4 (mglur4)

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Publication number
EA201691046A1
EA201691046A1 EA201691046A EA201691046A EA201691046A1 EA 201691046 A1 EA201691046 A1 EA 201691046A1 EA 201691046 A EA201691046 A EA 201691046A EA 201691046 A EA201691046 A EA 201691046A EA 201691046 A1 EA201691046 A1 EA 201691046A1
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EA
Eurasian Patent Office
Prior art keywords
hydrogen
lower alkyl
ethylimidazoline
mglur4
dion
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EA201691046A
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English (en)
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EA029967B1 (ru
Inventor
Барбара Биманс
Вольфганг Губа
Георг Ешке
Антонио Риччи
Даниэль Рюхер
Эрик Виейра
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Ф. Хоффманн-Ля Рош Аг
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49917002&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201691046(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of EA201691046A1 publication Critical patent/EA201691046A1/ru
Publication of EA029967B1 publication Critical patent/EA029967B1/ru

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    • C07D233/72—Two oxygen atoms, e.g. hydantoin
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    • A61K31/4164—1,3-Diazoles
    • A61K31/4166—1,3-Diazoles having oxo groups directly attached to the heterocyclic ring, e.g. phenytoin
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    • A61K31/4164—1,3-Diazoles
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

Настоящее изобретение относится к соединениям формулы Iгде Y представляет собой C-R; Rявляется водородом или галогеном; Rявляется водородом или галогеном; Rявляется водородом, низшим алкилом или фенилом; Rявляется водородом или низшим алкилом; или Rи Rмогут образовывать вместе с соответствующими атомами, к которым они присоединены, следующие кольцаRявляется водородом или низшим алкилом; и если Rи Rобразуют кольцо, такое как описано выше, то Rявляется водородом; или Rи Rвместе с атомом углерода, к которому они присоединены, могут образовывать гетероциклоалкильное кольцо; Rявляется фенилом или пиридинилом, где атом N пиридинильной группы может находиться в разных положениях; или к их фармацевтически приемлемой соли или соли присоединения кислоты, к рацемической смеси или ее соответствующему энантиомеру, и/или оптическому изомеру, и/или стереоизомеру. Соединения могут применяться для лечения болезни Паркинсона, тревожного расстройства, тошноты и рвоты, обессивно-компульсивного расстройства, аутизма, при нейропротекции, лечении онкологического заболевания, депрессивного синдрома и диабета 2 типа.
EA201691046A 2014-01-10 2015-01-07 Производные этинилимидазолин-2,4-диона в качестве модуляторов метаботропного глутаматного рецептора 4 (mglur4) EA029967B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14150700 2014-01-10
PCT/EP2015/050127 WO2015104271A1 (en) 2014-01-10 2015-01-07 Ethynyl-imidazolin-2,4-dione derivatives as mglur4 modulators

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EA201691046A1 true EA201691046A1 (ru) 2016-12-30
EA029967B1 EA029967B1 (ru) 2018-06-29

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US (1) US9695128B2 (ru)
EP (1) EP3092219B1 (ru)
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KR (1) KR101868248B1 (ru)
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AR (1) AR099047A1 (ru)
AU (1) AU2015205661B2 (ru)
BR (1) BR112016010168A2 (ru)
CA (1) CA2934768A1 (ru)
CL (1) CL2016001739A1 (ru)
CR (1) CR20160198A (ru)
EA (1) EA029967B1 (ru)
HK (1) HK1226054A1 (ru)
IL (1) IL245327B (ru)
MX (1) MX369820B (ru)
PE (1) PE20160860A1 (ru)
PH (1) PH12016501100A1 (ru)
SG (1) SG11201605557TA (ru)
TW (1) TWI649310B (ru)
UA (1) UA119053C2 (ru)
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Publication number Priority date Publication date Assignee Title
SI3110802T1 (sl) * 2014-02-25 2019-01-31 F. Hoffmann-La Roche Ag Derivati etinila
RS58929B1 (sr) 2015-07-15 2019-08-30 Hoffmann La Roche Derivati etinila kao modulatori metabotropnih glutamatnih receptora
AR105556A1 (es) * 2015-08-03 2017-10-18 Hoffmann La Roche Derivados de etinilo
RU2745068C2 (ru) 2016-07-18 2021-03-18 Ф. Хоффманн-Ля Рош Аг Производные этинила
JP7364553B2 (ja) * 2017-08-17 2023-10-18 エフ． ホフマン－ラ ロシュ アーゲー パーキンソン病等の疾患を処置するためのイミダゾ［１，２－ａ］イミダゾール－２－オン誘導体
US10893929B2 (en) 2018-01-10 2021-01-19 Cook Medical Technologies Llc Vascular graft with compartments for compliance matching
US10517713B2 (en) 2018-01-10 2019-12-31 Cook Medical Technologies Llc Vascular graft with helical flow compliance compartments
AU2019309448A1 (en) 2018-07-26 2021-01-14 Domain Therapeutics Substituted quinazolinone derivatives and their use as positive allosteric modulators of mGluR4

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MX2009013169A (es) * 2007-06-03 2010-04-30 Univ Vanderbilt Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos.
CN102740699A (zh) * 2009-09-04 2012-10-17 范德比尔特大学 用于治疗神经学上的功能失调的mglur4变构增效剂、组合物和方法
US8420661B2 (en) * 2010-04-13 2013-04-16 Hoffmann-La Roche Inc. Arylethynyl derivatives
US10533000B2 (en) * 2011-05-26 2020-01-14 Sunovion Pharmaceuticals, Inc. Metabotrophic glutamate receptor 5 modulators and methods of use thereof

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AR099047A1 (es) 2016-06-22
ZA201602890B (en) 2017-07-26
US20170008854A1 (en) 2017-01-12
SG11201605557TA (en) 2016-08-30
PH12016501100B1 (en) 2016-07-11
CL2016001739A1 (es) 2017-05-12
TWI649310B (zh) 2019-02-01
MX2016008887A (es) 2016-10-04
MX369820B (es) 2019-11-22
EP3092219B1 (en) 2018-09-19
AU2015205661B2 (en) 2018-08-23
UA119053C2 (uk) 2019-04-25
CR20160198A (es) 2016-06-17
HK1226054A1 (zh) 2017-09-22
KR101868248B1 (ko) 2018-06-15
IL245327A0 (en) 2016-06-30
CA2934768A1 (en) 2015-07-16
US9695128B2 (en) 2017-07-04
JP2017502066A (ja) 2017-01-19
IL245327B (en) 2018-12-31
KR20160095099A (ko) 2016-08-10
TW201531464A (zh) 2015-08-16
BR112016010168A2 (pt) 2017-08-08
CN106170479B (zh) 2019-02-12
EA029967B1 (ru) 2018-06-29
JP6263633B2 (ja) 2018-01-17
PH12016501100A1 (en) 2016-07-11
CN106170479A (zh) 2016-11-30
EP3092219A1 (en) 2016-11-16
WO2015104271A1 (en) 2015-07-16

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