PE20161559A1 - Peptidos como agonistas de la oxitocina - Google Patents

Peptidos como agonistas de la oxitocina

Info

Publication number
PE20161559A1
PE20161559A1 PE2016002397A PE2016002397A PE20161559A1 PE 20161559 A1 PE20161559 A1 PE 20161559A1 PE 2016002397 A PE2016002397 A PE 2016002397A PE 2016002397 A PE2016002397 A PE 2016002397A PE 20161559 A1 PE20161559 A1 PE 20161559A1
Authority
PE
Peru
Prior art keywords
hydrogen
lower alkyl
peptides
compounds
chr4
Prior art date
Application number
PE2016002397A
Other languages
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Konrad Bleicher
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50842169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20161559(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20161559A1 publication Critical patent/PE20161559A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Addiction (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Se refiere a un compuesto de formula I, donde: R1 es hidrogeno, alquilo inferior o cicloalquilo; R2 es hidrogeno; o R1 y R2 pueden forman junto con el atomo de N y C al que se unen un anillo pirrolidina, una azetidina o un anillo piperazina; R3 es hidrogeno, alquilo inferior, entre otros; R3’ es hidrogeno o alquilo inferior; X es –C(O)-CHR4-CHR4’-C(O)-NH-CH2-; R4 y R4’ son hidrogeno o uno de R4 o R4’ es amino; o es 0 o 1. Son compuestos preferidos los compuestos de formula i, ii, entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son peptidos agonistas del receptor de la oxitocina, siendo utiles en el tratamiento del autismo, el estres, entre otros.
PE2016002397A 2014-06-03 2015-06-01 Peptidos como agonistas de la oxitocina PE20161559A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14170992 2014-06-03

Publications (1)

Publication Number Publication Date
PE20161559A1 true PE20161559A1 (es) 2017-01-12

Family

ID=50842169

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2016002397A PE20161559A1 (es) 2014-06-03 2015-06-01 Peptidos como agonistas de la oxitocina

Country Status (16)

Country Link
US (1) US9957298B2 (es)
EP (1) EP3151849B1 (es)
JP (1) JP6412170B2 (es)
KR (1) KR20170004013A (es)
CN (1) CN106414479B (es)
AU (1) AU2015270723A1 (es)
CA (1) CA2949173A1 (es)
CL (1) CL2016003095A1 (es)
CR (1) CR20160563A (es)
EA (1) EA030091B1 (es)
IL (1) IL248553A0 (es)
MX (1) MX2016015873A (es)
PE (1) PE20161559A1 (es)
PH (1) PH12016502232A1 (es)
SG (1) SG11201610073PA (es)
WO (1) WO2015185467A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3666258T1 (sl) 2014-09-19 2024-04-30 Ferring Bv Postopek zdravljenja Prader-Willijevega sindroma
WO2019060962A1 (en) * 2017-09-28 2019-04-04 The University Of Sydney SELECTIVE AGONISTS OF THE OCYTOCIN RECEPTOR, INSPIRED BY METABOLITES
EP3852723A4 (en) * 2018-09-20 2022-06-29 Levo Therapeutics, Inc. Stable intranasal formulations of carbetocin
TW202034899A (zh) 2018-09-20 2020-10-01 克里斯托弗 Ｓ 布萊恩特 卡貝縮宮素藥品及其製備方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9701162D0 (sv) * 1997-03-27 1997-03-27 Karolinska Innovations Ab New use II
KR20070022753A (ko) * 2004-05-26 2007-02-27 화이자 인코포레이티드 인다졸 및 인돌론 유도체 및 이의 약제로서의 용도
EA026578B1 (ru) * 2007-01-22 2017-04-28 ДЖиТиЭкс, ИНК. Вещества, связывающие ядерные рецепторы
EP2260053B1 (en) * 2008-03-31 2014-05-14 Ferring BV Oxytocin analogues
WO2010034656A1 (en) * 2008-09-23 2010-04-01 F. Hoffmann-La Roche Ag Isoxazolo[4,5]pyridin-3-yl-piperazin derivatives useful as modulatorsof dopamine d3 receptors
MX2011011477A (es) * 2009-05-05 2011-11-18 Hoffmann La Roche Derivados de isoxazol-piridazina.
TWI463990B (zh) * 2009-09-21 2014-12-11 Ferring Bv 催產素受體促進劑
EP2482835B1 (en) * 2009-10-01 2014-07-02 The University Of Sydney Therapy and prevention of problem drinking
DK2935312T3 (en) 2012-12-21 2018-10-22 Hoffmann La Roche Peptides as oxytocin agonists

Also Published As

Publication number Publication date
CN106414479A (zh) 2017-02-15
AU2015270723A1 (en) 2016-11-17
US9957298B2 (en) 2018-05-01
SG11201610073PA (en) 2016-12-29
WO2015185467A1 (en) 2015-12-10
CL2016003095A1 (es) 2017-06-16
EP3151849B1 (en) 2018-10-10
KR20170004013A (ko) 2017-01-10
US20170081369A1 (en) 2017-03-23
JP6412170B2 (ja) 2018-10-24
CN106414479B (zh) 2021-08-03
PH12016502232A1 (en) 2017-01-09
EA030091B1 (ru) 2018-06-29
CA2949173A1 (en) 2015-12-10
IL248553A0 (en) 2016-12-29
EP3151849A1 (en) 2017-04-12
CR20160563A (es) 2017-01-06
JP2017518311A (ja) 2017-07-06
EA201692404A1 (ru) 2017-05-31
MX2016015873A (es) 2017-03-27

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