CR20160563A - Péptidos como agonistas de la oxitocina - Google Patents

Péptidos como agonistas de la oxitocina

Info

Publication number
CR20160563A
CR20160563A CR20160563A CR20160563A CR20160563A CR 20160563 A CR20160563 A CR 20160563A CR 20160563 A CR20160563 A CR 20160563A CR 20160563 A CR20160563 A CR 20160563A CR 20160563 A CR20160563 A CR 20160563A
Authority
CR
Costa Rica
Prior art keywords
hydrogen
lower alkyl
cycloalkyl
chr4
treatment
Prior art date
Application number
CR20160563A
Other languages
English (en)
Inventor
Caterina Bissantz
Konrad Bleicher
Christophe Grundschober
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50842169&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20160563(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CR20160563A publication Critical patent/CR20160563A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/16—Oxytocins; Vasopressins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Psychiatry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Addiction (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención se refiere a compuestos de fórmula en donde R1 es hidrógeno, alquilo inferior o cicloalquilo; R2 es hidrógeno o R1 y R2 pueden formar junto con el átomo de N y C al que están unidos un anillo de pirrolidina opcionalmente sustituido con uno o dos átomos de F o con hidroxi, o puede formar una azetidina o un anillo de piperazina; R3 es hidrógeno, alquilo inferior, alquilo inferior sustituido con hidroxi, -(CH2)2C(O)NH2, bencilo, fenilo, -CH2-grupo heterocíclico aromático de cinco miembros, CH2-indolilo, -CH2-cicloalquilo, cicloalquilo -(CH2)2-S-alquilo inferior; R3¿ es hidrógeno o alquilo inferior; o X es ¿C(O)-CHR4-CHR4¿-C(O)-NH-CH2- R4/R4¿ son hidrógeno o uno de R4 o R4¿ es amino: o es 0 o 1; o a una sal de adición de ácido farmacéuticamente aceptable, a una mezcla racémica o a sus enantiómeros y/o isómeros ópticos de los mismos. Se ha descubierto que los presentes compuestos son agonistas del receptor de oxitocina para el tratamiento del autismo, el estrés, incluyendo el trastorno de estrés postraumático, la ansiedad, incluyendo trastornos de ansiedad y la depresión, la esquizofrenia, trastornos psiquiátricos y la pérdida de memoria, la abstinencia del alcohol, adicción a las drogas y para el tratamiento del síndrome de Prader-Willi.
CR20160563A 2014-06-03 2015-06-01 Péptidos como agonistas de la oxitocina CR20160563A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14170992 2014-06-03
PCT/EP2015/062054 WO2015185467A1 (en) 2014-06-03 2015-06-01 Peptides as oxytocin agonists

Publications (1)

Publication Number Publication Date
CR20160563A true CR20160563A (es) 2017-01-06

Family

ID=50842169

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20160563A CR20160563A (es) 2014-06-03 2015-06-01 Péptidos como agonistas de la oxitocina

Country Status (16)

Country Link
US (1) US9957298B2 (es)
EP (1) EP3151849B1 (es)
JP (1) JP6412170B2 (es)
KR (1) KR20170004013A (es)
CN (1) CN106414479B (es)
AU (1) AU2015270723A1 (es)
CA (1) CA2949173A1 (es)
CL (1) CL2016003095A1 (es)
CR (1) CR20160563A (es)
EA (1) EA030091B1 (es)
IL (1) IL248553A0 (es)
MX (1) MX2016015873A (es)
PE (1) PE20161559A1 (es)
PH (1) PH12016502232A1 (es)
SG (1) SG11201610073PA (es)
WO (1) WO2015185467A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016044131A1 (en) 2014-09-19 2016-03-24 Ferring B.V. Method of treating prader-willi syndrome
US11414459B2 (en) 2017-09-28 2022-08-16 Kinoxis Therapeutics Pty Ltd Metabolite inspired selective oxytocin receptor agonists
AU2019345313A1 (en) 2018-09-20 2021-03-18 Levo Therapeutics, Inc. Carbetocin drug product and process for preparing same
AU2019345166B2 (en) * 2018-09-20 2021-09-02 Levo Therapeutics, Inc. Stable intranasal formulations of carbetocin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9701162D0 (sv) * 1997-03-27 1997-03-27 Karolinska Innovations Ab New use II
KR20070022753A (ko) * 2004-05-26 2007-02-27 화이자 인코포레이티드 인다졸 및 인돌론 유도체 및 이의 약제로서의 용도
WO2008091555A2 (en) * 2007-01-22 2008-07-31 Gtx, Inc. Nuclear receptor binding agents
NZ587817A (en) * 2008-03-31 2012-05-25 Ferring Bv Oxytocin analogues
KR20110076944A (ko) * 2008-09-23 2011-07-06 에프. 호프만-라 로슈 아게 도파민 ｄ3 수용체의 조절제로서 유용한 이속사졸로〔4,5〕피리딘-3-일-피페라진 유도체
CA2760597C (en) * 2009-05-05 2017-08-22 F. Hoffmann-La Roche Ag Isoxazole-pyridazine derivatives
TWI463990B (zh) * 2009-09-21 2014-12-11 Ferring Bv 催產素受體促進劑
WO2011038451A1 (en) * 2009-10-01 2011-04-07 The University Of Sydney Therapy and prevention of problem drinking
CA2895150C (en) 2012-12-21 2019-11-26 F. Hoffmann-La Roche Ag Peptides as oxytocin agonists

Also Published As

Publication number Publication date
KR20170004013A (ko) 2017-01-10
SG11201610073PA (en) 2016-12-29
CN106414479A (zh) 2017-02-15
US20170081369A1 (en) 2017-03-23
US9957298B2 (en) 2018-05-01
JP2017518311A (ja) 2017-07-06
CN106414479B (zh) 2021-08-03
PH12016502232A1 (en) 2017-01-09
IL248553A0 (en) 2016-12-29
WO2015185467A1 (en) 2015-12-10
EA201692404A1 (ru) 2017-05-31
CA2949173A1 (en) 2015-12-10
PE20161559A1 (es) 2017-01-12
MX2016015873A (es) 2017-03-27
EP3151849A1 (en) 2017-04-12
CL2016003095A1 (es) 2017-06-16
JP6412170B2 (ja) 2018-10-24
AU2015270723A1 (en) 2016-11-17
EP3151849B1 (en) 2018-10-10
EA030091B1 (ru) 2018-06-29

Similar Documents

Publication Publication Date Title
AR094225A1 (es) Peptidos como agonistas de oxitocina
EA201692488A1 (ru) Пептиды, выполняющие роль агонистов окситоцина
ES2521596T3 (es) Combinación del compuesto GlyT1 con antipsicóticos
AR119698A2 (es) Compuesto amida n-urea sustituida derivado de aminoácido
PH12016502231B1 (en) Indolin-2-one or pyrrolo-pyridin-2-one derivatives
PE20200008A1 (es) Isoquinolinas como inhibidores de hpk1
AR096640A1 (es) Derivados de indolin-2-ona o pirrolo-piridin / pirimidin-2-ona
CO2017011174A2 (es) Derivados de etileno como moduladores metabotropicos de receptores de glutamato
CR20160563A (es) Péptidos como agonistas de la oxitocina
AR105668A1 (es) 2-amino-3-fluoro-3-(fluorometil)-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas como inhibidores de bace1
AR092555A1 (es) 2-oxo-2,3-dihidro-indoles y su utilizacion para el tratamiento de trastornos del snc
PE20181853A1 (es) 1,5-dihidro-4h-pirazolo[3,4-d]pirimidin-4-onas y 1,5-dihidro-4h-pirazolo[4,3-c]piridin-4-onas como inhibidores de pde1
AR097721A1 (es) Derivados de etinilo
PE20190964A1 (es) Inhibidores de dopamina-b-hidroxilasa penetrantes de la barrera hematoencefalica
AR106588A1 (es) Derivados de indolin-2-ona para el tratamiento de enfermedades del snc
MX2015008830A (es) Agonistas del receptor de oxitocina para el tratamiento de enfermedades del sistema nervioso central.
AR105662A1 (es) Derivados de piridina y de pirimidina como inhibidores del eaat3
CR20130476A (es) Derivados de pirazolidin-3-ona
PE20161374A1 (es) Ciclopentanos, tetrahidrofuranos y pirrolidinas sustituidas como antagonistas del receptor de orexina
AR107490A1 (es) Derivados de pirazol-piridina como inhibidores de eaat3
PE20171349A1 (es) Inhibidores de bace1
PE20150685A1 (es) Pirimidinas de ariletinilo
UY36023A (es) “derivados cristalinos de (s)-1-((2r,3r,4s,5s)-5-alil-3-metoxi-4-(tosilmetil) tetrahidrofuran-2-il)-3-aminopropan-2-ol “.
AR062950A1 (es) Compuestos tetraciclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
TH167739A (th) เปปไทด์เป็นตัวทำการออกซีโทซิน