CA2727018A1 - Anthraquinones and analogs from rhuem palmatum for treatment of estrogen receptor beta-mediated conditions - Google Patents

Anthraquinones and analogs from rhuem palmatum for treatment of estrogen receptor beta-mediated conditions Download PDF

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Publication number
CA2727018A1
CA2727018A1 CA2727018A CA2727018A CA2727018A1 CA 2727018 A1 CA2727018 A1 CA 2727018A1 CA 2727018 A CA2727018 A CA 2727018A CA 2727018 A CA2727018 A CA 2727018A CA 2727018 A1 CA2727018 A1 CA 2727018A1
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CA
Canada
Prior art keywords
aqueous
composition
cell
ratio
acetonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2727018A
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English (en)
French (fr)
Inventor
Isaac Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bionovo Inc
Original Assignee
Bionovo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bionovo Inc filed Critical Bionovo Inc
Publication of CA2727018A1 publication Critical patent/CA2727018A1/en
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/708—Rheum (rhubarb)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Botany (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Pregnancy & Childbirth (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
CA2727018A 2008-06-06 2009-06-05 Anthraquinones and analogs from rhuem palmatum for treatment of estrogen receptor beta-mediated conditions Abandoned CA2727018A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5968608P 2008-06-06 2008-06-06
US61/059,686 2008-06-06
PCT/US2009/003427 WO2009148620A2 (en) 2008-06-06 2009-06-05 Anthraquinones and analogs from rhuem palmatum for treatment of estrogen receptor beta-mediated conditions

Publications (1)

Publication Number Publication Date
CA2727018A1 true CA2727018A1 (en) 2009-12-10

Family

ID=41398731

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2727018A Abandoned CA2727018A1 (en) 2008-06-06 2009-06-05 Anthraquinones and analogs from rhuem palmatum for treatment of estrogen receptor beta-mediated conditions

Country Status (6)

Country Link
US (1) US20090312437A1 (enExample)
EP (1) EP2303249A4 (enExample)
JP (1) JP2011522822A (enExample)
AU (1) AU2009255626A1 (enExample)
CA (1) CA2727018A1 (enExample)
WO (1) WO2009148620A2 (enExample)

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AU2008285325A1 (en) * 2007-08-08 2009-02-12 Bionovo, Inc. Extracts of Ligustrum lucidum and uses thereof
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AU2008296076A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. Estrogenic extracts of Pueraria lobata Willd, Ohwi of the Leguminosae family and uses thereof
US20090068298A1 (en) * 2007-09-07 2009-03-12 Bionovo, Inc. ESTROGENIC EXTRACTS OF Astragalus membranaceus Fisch. Bge. Var. mongolicus Bge. of the Leguminosae Family AND USES THEREOF
US20090130101A1 (en) * 2007-11-19 2009-05-21 Bionovo, Inc. Anti-cancer therapy with an extract of scutellaria barbata
AU2008326431A1 (en) * 2007-11-19 2009-05-28 Bionovo, Inc. Scutellaria barbata extract and combinations for the treatment of cancer
US8512961B2 (en) * 2007-11-19 2013-08-20 Bionovo, Inc. Methods of detecting and treatment of cancers using Scutellaria barbata extract
WO2009070478A2 (en) * 2007-11-19 2009-06-04 Bionovo, Inc. A process of making purified extract of scutellaria barbata d. don
AU2009236339A1 (en) * 2008-04-14 2009-10-22 Bionovo, Inc. Calycosin and analogs thereof for the treatment of estrogen receptor beta-mediated diseases
JP2011519947A (ja) * 2008-05-06 2011-07-14 バイオノボ・インコーポレーテッド 膣および外陰の委縮を治療するために使用するエストロゲン様抽出物
US20090311349A1 (en) * 2008-06-05 2009-12-17 Bionovo, Inc., A Delaware Corporation Method of quantification of multiple bioactives from botanical compositions
EP2323641A4 (en) * 2008-06-13 2012-06-20 Bionovo Inc NYASOL AND ANALOGUE THEREOF FOR THE TREATMENT OF ESTROGEN RECEPTOR-BETA-MEDIATED ILLNESSES
US20100069480A1 (en) * 2008-09-03 2010-03-18 Bionovo, Inc. A Delaware Corporation Methods and compositions for the treatment of cancer
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CN104058946B (zh) * 2014-06-30 2017-02-08 重庆第二师范学院 具有抗肿瘤活性的大黄素过渡金属配合物、制备方法及其应用
CN106153813A (zh) * 2016-08-29 2016-11-23 贵州信邦制药股份有限公司 骨痛药酒中大黄素的鉴别方法
CN106370767A (zh) * 2016-08-29 2017-02-01 贵州信邦制药股份有限公司 关节克痹丸中虎杖的鉴别方法
WO2019009354A1 (ja) * 2017-07-05 2019-01-10 株式会社沖縄リサーチセンター 排尿障害改善用組成物
CN110031588B (zh) * 2019-03-26 2021-02-09 浙江金大康动物保健品有限公司 一种畜禽抗病毒颗粒的一板多药味快速薄层鉴别方法
EP3953712A1 (en) * 2019-04-10 2022-02-16 Universität Zürich A method for determining the likelihood of a patient being responsive to cancer immunotherapy
CN109942650B (zh) * 2019-04-29 2022-04-15 广西壮族自治区中医药研究院 一种欧鼠李苷的提取方法及其医药用途
CN110057960A (zh) * 2019-05-07 2019-07-26 哈尔滨快好药业有限公司 一种颈康胶囊中何首乌的质量及安全性控制方法
KR102250681B1 (ko) * 2019-10-11 2021-05-11 부경대학교 산학협력단 결명자에서 분리된 화합물을 포함하는 우울증의 예방 또는 치료용 조성물
JP7610353B2 (ja) * 2020-03-03 2025-01-08 小林製薬株式会社 女性ホルモン様作用剤

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Also Published As

Publication number Publication date
WO2009148620A3 (en) 2010-03-04
EP2303249A2 (en) 2011-04-06
AU2009255626A1 (en) 2009-12-10
JP2011522822A (ja) 2011-08-04
WO2009148620A2 (en) 2009-12-10
US20090312437A1 (en) 2009-12-17
EP2303249A4 (en) 2012-05-30

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Effective date: 20130927