PL441664A1 - Nitroksylowa pochodna polifenolu, sposoby jej wytwarzania oraz jej zastosowanie - Google Patents

Nitroksylowa pochodna polifenolu, sposoby jej wytwarzania oraz jej zastosowanie

Info

Publication number
PL441664A1
PL441664A1 PL441664A PL44166422A PL441664A1 PL 441664 A1 PL441664 A1 PL 441664A1 PL 441664 A PL441664 A PL 441664A PL 44166422 A PL44166422 A PL 44166422A PL 441664 A1 PL441664 A1 PL 441664A1
Authority
PL
Poland
Prior art keywords
sub
polyphenol
derivative
production methods
nitroxy
Prior art date
Application number
PL441664A
Other languages
English (en)
Inventor
Adrian KONOPKO
Katarzyna SĘKTAS
Grzegorz Litwinienko
Anna BIELAK-ŻMIJEWSKA
Original Assignee
Uniwersytet Warszawski
Instytut Biologii Doświadczalnej Im. Marcelego Nenckiego Polskiej Akademii Nauk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniwersytet Warszawski, Instytut Biologii Doświadczalnej Im. Marcelego Nenckiego Polskiej Akademii Nauk filed Critical Uniwersytet Warszawski
Priority to PL441664A priority Critical patent/PL441664A1/pl
Priority to US18/881,181 priority patent/US20260008751A1/en
Priority to CN202380049758.1A priority patent/CN120265612A/zh
Priority to EP23761250.2A priority patent/EP4551557A1/en
Priority to PCT/PL2023/050049 priority patent/WO2024010473A1/en
Priority to JP2024577429A priority patent/JP2025522861A/ja
Priority to AU2023302863A priority patent/AU2023302863A1/en
Publication of PL441664A1 publication Critical patent/PL441664A1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Anti-Oxidant Or Stabilizer Compositions (AREA)

Abstract

Przedmiotem zgłoszenia jest nitroksylowa pochodna polifenolu o wzorze: Q-(L-A)<sub>n</sub>, w którym Q oznacza grupę pochodzącą od polifenolu; L oznacza estrową grupę łączącą zawierającą od 1 do 3 atomów węgla; A oznacza 5 lub 6 członową grupę heterocykliczną zawierającą jeden atom azotu, który jest w postaci rodnika nitroksylowego (NO•), w której oba atomy węgla sąsiadujące z rodnikiem nitroksylowym są podstawione niezależnie od siebie przez jedną lub dwie grupy C<sub>1</sub>-C<sub>3</sub> alkilowe; i n oznacza liczbę całkowitą od 1 do 5. Przedmiotem zgłoszenia są również sposoby otrzymywania powyżej określonej pochodnej oraz jej zastosowanie jako środka przeciwutleniającego, zwłaszcza przeciwstarzeniowego.
PL441664A 2022-07-07 2022-07-07 Nitroksylowa pochodna polifenolu, sposoby jej wytwarzania oraz jej zastosowanie PL441664A1 (pl)

Priority Applications (7)

Application Number Priority Date Filing Date Title
PL441664A PL441664A1 (pl) 2022-07-07 2022-07-07 Nitroksylowa pochodna polifenolu, sposoby jej wytwarzania oraz jej zastosowanie
US18/881,181 US20260008751A1 (en) 2022-07-07 2023-07-04 Nitroxyl polyphenol derivative, methods for the preparation thereof and use thereof
CN202380049758.1A CN120265612A (zh) 2022-07-07 2023-07-04 硝酰多酚衍生物，其制备方法及其用途
EP23761250.2A EP4551557A1 (en) 2022-07-07 2023-07-04 Nitroxyl polyphenol derivative, methods for the preparation thereof and use thereof
PCT/PL2023/050049 WO2024010473A1 (en) 2022-07-07 2023-07-04 Nitroxyl polyphenol derivative, methods for the preparation thereof and use thereof
JP2024577429A JP2025522861A (ja) 2022-07-07 2023-07-04 ニトロキシルポリフェノール誘導体、その調製方法およびその使用
AU2023302863A AU2023302863A1 (en) 2022-07-07 2023-07-04 Nitroxyl polyphenol derivative, methods for the preparation thereof and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL441664A PL441664A1 (pl) 2022-07-07 2022-07-07 Nitroksylowa pochodna polifenolu, sposoby jej wytwarzania oraz jej zastosowanie

Publications (1)

Publication Number Publication Date
PL441664A1 true PL441664A1 (pl) 2024-01-08

Family

ID=87800756

Family Applications (1)

Application Number Title Priority Date Filing Date
PL441664A PL441664A1 (pl) 2022-07-07 2022-07-07 Nitroksylowa pochodna polifenolu, sposoby jej wytwarzania oraz jej zastosowanie

Country Status (7)

Country Link
US (1) US20260008751A1 (pl)
EP (1) EP4551557A1 (pl)
JP (1) JP2025522861A (pl)
CN (1) CN120265612A (pl)
AU (1) AU2023302863A1 (pl)
PL (1) PL441664A1 (pl)
WO (1) WO2024010473A1 (pl)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012111700A (ja) * 2010-11-22 2012-06-14 Univ Of Tsukuba 高分子化環状ニトロキシドラジカル化合物の潰瘍性消化管の炎症の処置剤
CN110152009A (zh) * 2019-05-09 2019-08-23 中国科学院兰州化学物理研究所 一种多取代白藜芦醇自旋标记衍生物及其制备方法和应用
CN113845460A (zh) * 2021-07-29 2021-12-28 浙江海洋大学 一种高光敏杀菌活性的姜黄素衍生物、制备方法、鲜虾光动力杀菌保鲜方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003243282B2 (en) * 2002-05-17 2008-05-01 Othera Holding, Inc. Amelioration of the development of cataracts and other opthalmic diseases
US10478513B2 (en) * 2015-08-18 2019-11-19 The Regents Of The University Of Califonia Nitroxide containing amyloid binding agents for imaging and therapeutic uses

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012111700A (ja) * 2010-11-22 2012-06-14 Univ Of Tsukuba 高分子化環状ニトロキシドラジカル化合物の潰瘍性消化管の炎症の処置剤
CN110152009A (zh) * 2019-05-09 2019-08-23 中国科学院兰州化学物理研究所 一种多取代白藜芦醇自旋标记衍生物及其制备方法和应用
CN113845460A (zh) * 2021-07-29 2021-12-28 浙江海洋大学 一种高光敏杀菌活性的姜黄素衍生物、制备方法、鲜虾光动力杀菌保鲜方法

Also Published As

Publication number Publication date
US20260008751A1 (en) 2026-01-08
WO2024010473A1 (en) 2024-01-11
JP2025522861A (ja) 2025-07-17
CN120265612A (zh) 2025-07-04
AU2023302863A1 (en) 2025-01-09
EP4551557A1 (en) 2025-05-14

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