EA200970266A1 - Азабициклические соединения в качестве ингибиторов повторного поглощения моноаминов - Google Patents
Азабициклические соединения в качестве ингибиторов повторного поглощения моноаминовInfo
- Publication number
- EA200970266A1 EA200970266A1 EA200970266A EA200970266A EA200970266A1 EA 200970266 A1 EA200970266 A1 EA 200970266A1 EA 200970266 A EA200970266 A EA 200970266A EA 200970266 A EA200970266 A EA 200970266A EA 200970266 A1 EA200970266 A1 EA 200970266A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- 6alkyl
- halogen
- hydrogen
- salkoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Gynecology & Obstetrics (AREA)
- Endocrinology (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- Pregnancy & Childbirth (AREA)
- Child & Adolescent Psychology (AREA)
- Oncology (AREA)
- Emergency Medicine (AREA)
Abstract
Данное изобретение относится к новым соединениям формулы (I)', его фармацевтически приемлемым солям, пролекарствам или сольватамгде Rпредставляет водород или Салкил; Rпредставляет группу А, K или W; где А представляетK представляет группу α или β нафтила, необязательно замещенного 1 или 2 группами R, которые могут быть одинаковыми или разными, и W представляети где G представляет 5- или 6-членную моноциклическую гетероарильную или 8-11-членную бициклическую группу; такая группа G может быть замещена (R), которые могут быть одинаковыми или разными, р означает целое число от 0 до 5; Rвыбран из группы, состоящей из водорода, фтора и Cалкила, или соответствует группе Х или X; Rвыбран из группы, состоящей из водорода, фтора и Cалкила, или соответствует группе Х или X; Rпредставляет водород или Салкил; Rпредставляет водород или Салкил или представляет группу X, X, Хили Х; где Х представляетXпредставляетXпредставляети ХпредставляетRпредставляет водород или Салкил или представляет группу Х или X; Rпредставляет Салкил; Rвыбран из группы, состоящей из водорода, галогена, гидрокси, циано, Салкила, галоген-Салкила, Салкокси, галоген-Салкокси, Салканоила и SF, или соответствует группе R; Rпредставляет 5-6-членную гетероциклическую группу, которая может быть необязательно замещена одним или двумя заместителями, выбранными из группы, состоящей из галогена, циано, Салкила, галоген-Салкила, Салкокси и Салканоила; Rвыбран из группы, состоящей из водорода, галогена, гидрокси, циано, Салкила, галоген-Салкила, Салкокси, галоген-Салкокси, Салканоила и SF, или соответствует группе R; Rвыбран из группы, состоящей из водорода, галогена, гидрокси, циано, Салкила, галоген-Салкила, Салкокси, галоген-Салкокси, Салканоила и SF, или
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0617863A GB0617863D0 (en) | 2006-09-11 | 2006-09-11 | Chemical compounds |
| GB0617868A GB0617868D0 (en) | 2006-09-11 | 2006-09-11 | Chemical compounds |
| GB0716371A GB0716371D0 (en) | 2007-08-22 | 2007-08-22 | Chemical compounds |
| PCT/EP2007/059381 WO2008031772A1 (en) | 2006-09-11 | 2007-09-07 | Azabicyclic compounds as inhibitors of monoamines reuptake |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA200970266A1 true EA200970266A1 (ru) | 2009-08-28 |
Family
ID=38561834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200970266A EA200970266A1 (ru) | 2006-09-11 | 2007-09-07 | Азабициклические соединения в качестве ингибиторов повторного поглощения моноаминов |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7691893B2 (ru) |
| EP (1) | EP2064186A1 (ru) |
| JP (1) | JP4448198B2 (ru) |
| KR (1) | KR20090064447A (ru) |
| AR (1) | AR062737A1 (ru) |
| AU (1) | AU2007296301A1 (ru) |
| BR (1) | BRPI0716532A2 (ru) |
| CA (1) | CA2662538A1 (ru) |
| CL (1) | CL2007002619A1 (ru) |
| CO (1) | CO6150149A2 (ru) |
| CR (1) | CR10671A (ru) |
| EA (1) | EA200970266A1 (ru) |
| IL (1) | IL197297A0 (ru) |
| MA (1) | MA30767B1 (ru) |
| MX (1) | MX2009002625A (ru) |
| NO (1) | NO20091099L (ru) |
| PE (1) | PE20081368A1 (ru) |
| TW (1) | TW200826934A (ru) |
| WO (1) | WO2008031772A1 (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7691893B2 (en) | 2006-09-11 | 2010-04-06 | Glaxo Group Limited | Chemical compounds |
| GB0716573D0 (en) * | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Chemical compounds |
| GB0804326D0 (en) * | 2008-03-07 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
| WO2010125033A1 (en) * | 2009-04-29 | 2010-11-04 | Glaxo Group Limited | Azabicyclo[4.1.0]heptane derivatives |
| WO2010130672A1 (en) * | 2009-05-12 | 2010-11-18 | Glaxo Group Limited | Azabicyclo [4.1.0] heptane derivatives and their use as monoamine reuptake inhibitors |
| WO2010133569A1 (en) * | 2009-05-20 | 2010-11-25 | Glaxo Group Limited | Azabicyclo[4.1.0]heptane derivatives |
| WO2010146025A1 (en) * | 2009-06-17 | 2010-12-23 | Glaxo Group Limited | Tricyclic azabicyclo [4.1.0] heptane derivatives as inhibitors of serotonin, dopamine and norepinephrine re-uptake |
| KR101458007B1 (ko) | 2010-09-22 | 2014-11-04 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 사이클로프로판 화합물 |
| DE102011100831A1 (de) | 2011-05-07 | 2012-11-08 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von GSK 1360707 und verwandter Verbindungen mit 6-Aryl-1-[(alkyloxy) alkyl]-3-azabicyclo[4.1.0]heptan Grundgerüst |
| MX2017004950A (es) | 2014-10-23 | 2018-01-16 | Eisai R&D Man Co Ltd | Composiciones y metodos para tratar el insomnio. |
| MX2023001818A (es) | 2020-08-13 | 2023-03-13 | Boehringer Ingelheim Int | Compuestos para usarse en tratamiento de deterioro cognitivo asociado con la esquizofrenia. |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2008A (en) * | 1841-03-18 | Gas-lamp eok conducting gas pkom ah elevated buhner to one below it | ||
| US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
| US4131611A (en) * | 1975-07-31 | 1978-12-26 | American Cyanamid Company | Azabicyclohexanes |
| US4435419A (en) * | 1981-07-01 | 1984-03-06 | American Cyanamid Company | Method of treating depression using azabicyclohexanes |
| AU672644B2 (en) | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
| AU720358B2 (en) * | 1996-02-22 | 2000-06-01 | Neurosearch A/S | Tropane-derivatives, their preparation and use |
| CA2284732C (en) * | 1997-04-07 | 2008-06-17 | Georgetown University | Analogs of cocaine |
| US6303627B1 (en) | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
| US6372919B1 (en) * | 2001-01-11 | 2002-04-16 | Dov Pharmaceutical, Inc. | (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent |
| US6569887B2 (en) * | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
| US20060173064A1 (en) | 2001-08-24 | 2006-08-03 | Lippa Arnold S | (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders |
| US7223788B2 (en) * | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| ATE471320T1 (de) | 2004-02-27 | 2010-07-15 | Lilly Co Eli | 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme |
| US7691893B2 (en) | 2006-09-11 | 2010-04-06 | Glaxo Group Limited | Chemical compounds |
-
2007
- 2007-09-07 US US11/851,459 patent/US7691893B2/en not_active Expired - Fee Related
- 2007-09-07 MX MX2009002625A patent/MX2009002625A/es unknown
- 2007-09-07 AU AU2007296301A patent/AU2007296301A1/en not_active Abandoned
- 2007-09-07 BR BRPI0716532-3A2A patent/BRPI0716532A2/pt not_active IP Right Cessation
- 2007-09-07 EA EA200970266A patent/EA200970266A1/ru unknown
- 2007-09-07 US US12/440,852 patent/US20100035914A1/en not_active Abandoned
- 2007-09-07 EP EP07803326A patent/EP2064186A1/en not_active Withdrawn
- 2007-09-07 CA CA002662538A patent/CA2662538A1/en not_active Abandoned
- 2007-09-07 WO PCT/EP2007/059381 patent/WO2008031772A1/en active Application Filing
- 2007-09-07 KR KR1020097007365A patent/KR20090064447A/ko not_active Application Discontinuation
- 2007-09-07 PE PE2007001202A patent/PE20081368A1/es not_active Application Discontinuation
- 2007-09-07 JP JP2009527793A patent/JP4448198B2/ja not_active Expired - Fee Related
- 2007-09-10 TW TW096133638A patent/TW200826934A/zh unknown
- 2007-09-10 CL CL200702619A patent/CL2007002619A1/es unknown
- 2007-09-11 AR ARP070104006A patent/AR062737A1/es not_active Application Discontinuation
-
2009
- 2009-02-26 IL IL197297A patent/IL197297A0/en unknown
- 2009-03-10 CO CO09024346A patent/CO6150149A2/es unknown
- 2009-03-13 NO NO20091099A patent/NO20091099L/no not_active Application Discontinuation
- 2009-03-19 CR CR10671A patent/CR10671A/es not_active Application Discontinuation
- 2009-03-30 MA MA31737A patent/MA30767B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090064447A (ko) | 2009-06-18 |
| BRPI0716532A2 (pt) | 2013-09-24 |
| IL197297A0 (en) | 2009-12-24 |
| AR062737A1 (es) | 2008-11-26 |
| JP2010502761A (ja) | 2010-01-28 |
| NO20091099L (no) | 2009-04-03 |
| CR10671A (es) | 2009-04-29 |
| EP2064186A1 (en) | 2009-06-03 |
| CA2662538A1 (en) | 2008-03-20 |
| AU2007296301A1 (en) | 2008-03-20 |
| MX2009002625A (es) | 2009-03-24 |
| MA30767B1 (fr) | 2009-10-01 |
| TW200826934A (en) | 2008-07-01 |
| CL2007002619A1 (es) | 2008-04-18 |
| US20100035914A1 (en) | 2010-02-11 |
| PE20081368A1 (es) | 2008-11-19 |
| JP4448198B2 (ja) | 2010-04-07 |
| US20080114049A1 (en) | 2008-05-15 |
| WO2008031772A1 (en) | 2008-03-20 |
| US7691893B2 (en) | 2010-04-06 |
| CO6150149A2 (es) | 2010-04-20 |
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