NO20060145L - Substituerte indazolyl (indolyl) maleimidderivater som kinase inhibitorer - Google Patents
Substituerte indazolyl (indolyl) maleimidderivater som kinase inhibitorerInfo
- Publication number
- NO20060145L NO20060145L NO20060145A NO20060145A NO20060145L NO 20060145 L NO20060145 L NO 20060145L NO 20060145 A NO20060145 A NO 20060145A NO 20060145 A NO20060145 A NO 20060145A NO 20060145 L NO20060145 L NO 20060145L
- Authority
- NO
- Norway
- Prior art keywords
- sub
- kinase inhibitors
- kinase
- indolyl
- compounds
- Prior art date
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
- Virology (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Endocrinology (AREA)
Abstract
Foreliggende oppfinnelse angår nye indazolyl-substituerte pyrrolinforbindelser med formel (I): R2 er valgt fra gruppen som består av -C1-8 alkyl-Z, -C2-8 alkenyl-Z og -C2-8 alkynyl-Z; hvori -C1-8 alkyl-Z, -C2-8 alkenyl-Z og -C2-8 alkynyl-Z og Z er en 5 til 6 leddet aromatisk monosyklisk heteroaryl ring som har fra 2 til 4 heteroatomer. Disse forbindelser er anvendelige som kinase eller dual-kinase inhibitorer, fremgangsmåte for fremstilling av slike forbindelser og fremgangsmåte for behandling eller lindring av en kinase eller dual-kinasemediert forstyrrelse.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47851603P | 2003-06-13 | 2003-06-13 | |
PCT/US2004/017375 WO2005000836A1 (en) | 2003-06-13 | 2004-06-01 | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20060145L true NO20060145L (no) | 2006-03-07 |
Family
ID=33551833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20060145A NO20060145L (no) | 2003-06-13 | 2006-01-10 | Substituerte indazolyl (indolyl) maleimidderivater som kinase inhibitorer |
Country Status (22)
Country | Link |
---|---|
US (1) | US7439363B2 (no) |
EP (1) | EP1654255B1 (no) |
JP (1) | JP2007500748A (no) |
KR (1) | KR20060021890A (no) |
CN (1) | CN1832940A (no) |
AT (1) | ATE406365T1 (no) |
AU (1) | AU2004251178A1 (no) |
BR (1) | BRPI0411366A (no) |
CA (1) | CA2529353A1 (no) |
CO (1) | CO5650246A2 (no) |
CR (1) | CR8148A (no) |
DE (1) | DE602004016174D1 (no) |
EA (1) | EA200600032A1 (no) |
EC (1) | ECSP056222A (no) |
ES (1) | ES2311161T3 (no) |
HR (1) | HRP20050991A2 (no) |
IL (1) | IL172456A0 (no) |
IS (1) | IS8174A (no) |
NO (1) | NO20060145L (no) |
RS (1) | RS20050915A (no) |
WO (1) | WO2005000836A1 (no) |
ZA (1) | ZA200600294B (no) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002230727A1 (en) * | 2000-12-08 | 2002-06-18 | Ortho-Mcneil Pharmaceutical, Inc. | Indazolyl-substituted pyrroline compounds as kinase inhibitors |
AU2003225295A1 (en) * | 2002-05-08 | 2003-11-11 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
JP2005531607A (ja) * | 2002-06-05 | 2005-10-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤として置換ピロリン |
US7488826B2 (en) * | 2003-03-27 | 2009-02-10 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
EP2258357A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
EP2275095A3 (en) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
JP2009510085A (ja) * | 2005-09-29 | 2009-03-12 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼインヒビターとしての大型複素環式化合物 |
EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2382975A3 (en) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
KR101284836B1 (ko) | 2006-05-25 | 2013-07-10 | 삼성전자주식회사 | 이동통신시스템에서 자원 할당 맵 구성 방법 |
KR20090047458A (ko) | 2006-08-08 | 2009-05-12 | 사노피-아벤티스 | 아릴아미노아릴-알킬-치환된 이미다졸리딘-2,4-디온, 이의 제조방법, 이들 화합물을 포함하는 약제 및 이의 용도 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2008037266A1 (en) * | 2006-09-25 | 2008-04-03 | Universite Libre De Bruxelles | Inhibitors of conventional protein kinase c isozymes and use thereof for treating inflammatory diseases |
KR20090100363A (ko) | 2006-12-19 | 2009-09-23 | 노파르티스 아게 | 키나제 억제제로서의 인돌릴말레이미드 유도체 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
AR072707A1 (es) | 2008-07-09 | 2010-09-15 | Sanofi Aventis | Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
WO2011023754A1 (en) | 2009-08-26 | 2011-03-03 | Sanofi-Aventis | Novel crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
ES2387359B1 (es) * | 2011-02-25 | 2013-08-01 | Consejo Superior De Investigaciones Científicas (Csic) | Inhibidores de GSK-3 útiles en enfermedades neurodegenerativas, inflamatorias, cáncer, diabetes y en procesos regenerativos |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683698B1 (de) | 2011-03-08 | 2017-10-04 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
WO2012120058A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
US8809324B2 (en) | 2011-03-08 | 2014-08-19 | Sanofi | Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof |
CN102344443A (zh) * | 2011-07-15 | 2012-02-08 | 南开大学 | 点击化学合成开环马来酰亚胺类化合物及其在治疗疾病中的应用 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
CN103622964B (zh) * | 2013-12-04 | 2015-09-23 | 李强 | Trigolutesins A在治疗或预防急性心衰药物中的应用 |
US10220408B2 (en) * | 2016-09-12 | 2019-03-05 | The Boeing Company | Variable radius print head end effector |
CN108586432B (zh) * | 2018-05-31 | 2020-08-25 | 温州医科大学 | 一种3-(吲哚-5-基)-吲唑衍生物及其应用 |
US20220133740A1 (en) | 2019-02-08 | 2022-05-05 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK75289A3 (en) * | 1988-02-10 | 1998-05-06 | Hoffmann La Roche | Substituted pyrroles, their use for producing a drug, and the drug on their base |
GB8904161D0 (en) * | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
SE9603283D0 (sv) * | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
CA2338866A1 (en) | 1998-07-30 | 2000-02-10 | Japan Tobacco Inc. | Disubstituted maleimide compound and pharmaceutical use thereof |
ATE284387T1 (de) | 1998-10-08 | 2004-12-15 | Smithkline Beecham Plc | 3-(3-chloro-4-hydroxyphenylamino)-4-(2- nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
AU2002230727A1 (en) * | 2000-12-08 | 2002-06-18 | Ortho-Mcneil Pharmaceutical, Inc. | Indazolyl-substituted pyrroline compounds as kinase inhibitors |
AU2003225295A1 (en) * | 2002-05-08 | 2003-11-11 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
JP2005531607A (ja) * | 2002-06-05 | 2005-10-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤として置換ピロリン |
AU2003238874A1 (en) * | 2002-06-05 | 2003-12-22 | Janssen Pharmaceutica N.V. | Bisindolyl-maleimid derivatives as kinase inhibitors |
US7488826B2 (en) * | 2003-03-27 | 2009-02-10 | Janssen Pharmaceutica N.V. | Substituted pyrroline kinase inhibitors |
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2004
- 2004-06-01 KR KR1020057023946A patent/KR20060021890A/ko not_active Application Discontinuation
- 2004-06-01 JP JP2006533550A patent/JP2007500748A/ja not_active Withdrawn
- 2004-06-01 WO PCT/US2004/017375 patent/WO2005000836A1/en active Application Filing
- 2004-06-01 EA EA200600032A patent/EA200600032A1/ru unknown
- 2004-06-01 EP EP04754066A patent/EP1654255B1/en not_active Expired - Lifetime
- 2004-06-01 US US10/858,212 patent/US7439363B2/en not_active Expired - Fee Related
- 2004-06-01 AT AT04754066T patent/ATE406365T1/de not_active IP Right Cessation
- 2004-06-01 DE DE602004016174T patent/DE602004016174D1/de not_active Expired - Fee Related
- 2004-06-01 RS YUP-2005/0915A patent/RS20050915A/sr unknown
- 2004-06-01 BR BRPI0411366-7A patent/BRPI0411366A/pt not_active IP Right Cessation
- 2004-06-01 ES ES04754066T patent/ES2311161T3/es not_active Expired - Lifetime
- 2004-06-01 CN CNA200480022892XA patent/CN1832940A/zh active Pending
- 2004-06-01 CA CA002529353A patent/CA2529353A1/en not_active Abandoned
- 2004-06-01 AU AU2004251178A patent/AU2004251178A1/en not_active Abandoned
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2005
- 2005-12-08 IL IL172456A patent/IL172456A0/en unknown
- 2005-12-09 IS IS8174A patent/IS8174A/is unknown
- 2005-12-13 HR HR20050991A patent/HRP20050991A2/xx not_active Application Discontinuation
- 2005-12-13 CR CR8148A patent/CR8148A/es not_active Application Discontinuation
- 2005-12-13 EC EC2005006222A patent/ECSP056222A/es unknown
- 2005-12-19 CO CO05127381A patent/CO5650246A2/es not_active Application Discontinuation
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2006
- 2006-01-10 NO NO20060145A patent/NO20060145L/no not_active Application Discontinuation
- 2006-01-12 ZA ZA200600294A patent/ZA200600294B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
EA200600032A1 (ru) | 2006-06-30 |
ATE406365T1 (de) | 2008-09-15 |
CR8148A (es) | 2008-09-10 |
CN1832940A (zh) | 2006-09-13 |
CA2529353A1 (en) | 2005-01-06 |
ZA200600294B (en) | 2007-04-25 |
IL172456A0 (en) | 2006-04-10 |
IS8174A (is) | 2005-12-09 |
US7439363B2 (en) | 2008-10-21 |
BRPI0411366A (pt) | 2006-07-25 |
JP2007500748A (ja) | 2007-01-18 |
DE602004016174D1 (de) | 2008-10-09 |
HRP20050991A2 (en) | 2006-09-30 |
WO2005000836A1 (en) | 2005-01-06 |
EP1654255A1 (en) | 2006-05-10 |
EP1654255B1 (en) | 2008-08-27 |
ES2311161T3 (es) | 2009-02-01 |
KR20060021890A (ko) | 2006-03-08 |
ECSP056222A (es) | 2006-04-19 |
US20050004201A1 (en) | 2005-01-06 |
RS20050915A (sr) | 2008-04-04 |
AU2004251178A1 (en) | 2005-01-06 |
CO5650246A2 (es) | 2006-06-30 |
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