CR8148A - Derivados del indazolil (indolil) maleimida sustituidos como inhibidores de la cinasa - Google Patents

Derivados del indazolil (indolil) maleimida sustituidos como inhibidores de la cinasa

Info

Publication number
CR8148A
CR8148A CR8148A CR8148A CR8148A CR 8148 A CR8148 A CR 8148A CR 8148 A CR8148 A CR 8148A CR 8148 A CR8148 A CR 8148A CR 8148 A CR8148 A CR 8148A
Authority
CR
Costa Rica
Prior art keywords
sub
inhibitors
kinase
indazolil
maleimida
Prior art date
Application number
CR8148A
Other languages
English (en)
Inventor
Zhang Han-Cheng
E Maryanoff Bruce
Ye Hong
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CR8148A publication Critical patent/CR8148A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
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    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Molecular Biology (AREA)
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  • Transplantation (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)

Abstract

La presente invencion se dirige a compuestos novedosos de compuestos de pirrolina sustituida con indazolilo de formula (I): formula (I), R2 se selecciona a partir del grupo que consiste de -alquilo de C1-8-Z, -alquenilo de C2-8-Z y -alquinilo de C2-8-Z; en donde el -alquilo de C1-8-Z, -alquenilo de C2-8-Z y -alquinilo de C2-8-Z y Z es un anillo heteroarilo monociclico aromatico de 5 a 6 miembros que tiene de 2 a 4 heteroatomos; estos compuestos son utiles con inhibidores de cinasa o cinasa-dual, metodos para producir dichos compuestos y metodos para tratamiento o mejoria de un trastorno mediado por cinasa o cinasa-dual.
CR8148A 2003-06-13 2005-12-13 Derivados del indazolil (indolil) maleimida sustituidos como inhibidores de la cinasa CR8148A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47851603P 2003-06-13 2003-06-13

Publications (1)

Publication Number Publication Date
CR8148A true CR8148A (es) 2008-09-10

Family

ID=33551833

Family Applications (1)

Application Number Title Priority Date Filing Date
CR8148A CR8148A (es) 2003-06-13 2005-12-13 Derivados del indazolil (indolil) maleimida sustituidos como inhibidores de la cinasa

Country Status (22)

Country Link
US (1) US7439363B2 (es)
EP (1) EP1654255B1 (es)
JP (1) JP2007500748A (es)
KR (1) KR20060021890A (es)
CN (1) CN1832940A (es)
AT (1) ATE406365T1 (es)
AU (1) AU2004251178A1 (es)
BR (1) BRPI0411366A (es)
CA (1) CA2529353A1 (es)
CO (1) CO5650246A2 (es)
CR (1) CR8148A (es)
DE (1) DE602004016174D1 (es)
EA (1) EA200600032A1 (es)
EC (1) ECSP056222A (es)
ES (1) ES2311161T3 (es)
HR (1) HRP20050991A2 (es)
IL (1) IL172456A0 (es)
IS (1) IS8174A (es)
NO (1) NO20060145L (es)
RS (1) RS20050915A (es)
WO (1) WO2005000836A1 (es)
ZA (1) ZA200600294B (es)

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EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
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ES2387359B1 (es) * 2011-02-25 2013-08-01 Consejo Superior De Investigaciones Científicas (Csic) Inhibidores de GSK-3 útiles en enfermedades neurodegenerativas, inflamatorias, cáncer, diabetes y en procesos regenerativos
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DE60323749D1 (de) 2002-06-05 2008-11-06 Janssen Pharmaceutica Nv Substituierte pyrroline als kinase inhibitoren
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Publication number Publication date
US7439363B2 (en) 2008-10-21
IS8174A (is) 2005-12-09
ZA200600294B (en) 2007-04-25
DE602004016174D1 (de) 2008-10-09
ECSP056222A (es) 2006-04-19
CA2529353A1 (en) 2005-01-06
EP1654255B1 (en) 2008-08-27
AU2004251178A1 (en) 2005-01-06
HRP20050991A2 (en) 2006-09-30
JP2007500748A (ja) 2007-01-18
CO5650246A2 (es) 2006-06-30
US20050004201A1 (en) 2005-01-06
RS20050915A (sr) 2008-04-04
EA200600032A1 (ru) 2006-06-30
CN1832940A (zh) 2006-09-13
IL172456A0 (en) 2006-04-10
BRPI0411366A (pt) 2006-07-25
NO20060145L (no) 2006-03-07
ES2311161T3 (es) 2009-02-01
ATE406365T1 (de) 2008-09-15
KR20060021890A (ko) 2006-03-08
EP1654255A1 (en) 2006-05-10
WO2005000836A1 (en) 2005-01-06

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