DE602004016174D1 - Substituierte indazolyl(indolyl)maleimid-derivate als kinase inhibitoren - Google Patents
Substituierte indazolyl(indolyl)maleimid-derivate als kinase inhibitorenInfo
- Publication number
- DE602004016174D1 DE602004016174D1 DE602004016174T DE602004016174T DE602004016174D1 DE 602004016174 D1 DE602004016174 D1 DE 602004016174D1 DE 602004016174 T DE602004016174 T DE 602004016174T DE 602004016174 T DE602004016174 T DE 602004016174T DE 602004016174 D1 DE602004016174 D1 DE 602004016174D1
- Authority
- DE
- Germany
- Prior art keywords
- sub
- kinase inhibitors
- kinase
- maleimid
- indolyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47851603P | 2003-06-13 | 2003-06-13 | |
PCT/US2004/017375 WO2005000836A1 (en) | 2003-06-13 | 2004-06-01 | Substituted indazolyl(indolyl)maleimide derivatives as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602004016174D1 true DE602004016174D1 (de) | 2008-10-09 |
Family
ID=33551833
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602004016174T Expired - Fee Related DE602004016174D1 (de) | 2003-06-13 | 2004-06-01 | Substituierte indazolyl(indolyl)maleimid-derivate als kinase inhibitoren |
Country Status (22)
Country | Link |
---|---|
US (1) | US7439363B2 (de) |
EP (1) | EP1654255B1 (de) |
JP (1) | JP2007500748A (de) |
KR (1) | KR20060021890A (de) |
CN (1) | CN1832940A (de) |
AT (1) | ATE406365T1 (de) |
AU (1) | AU2004251178A1 (de) |
BR (1) | BRPI0411366A (de) |
CA (1) | CA2529353A1 (de) |
CO (1) | CO5650246A2 (de) |
CR (1) | CR8148A (de) |
DE (1) | DE602004016174D1 (de) |
EA (1) | EA200600032A1 (de) |
EC (1) | ECSP056222A (de) |
ES (1) | ES2311161T3 (de) |
HR (1) | HRP20050991A2 (de) |
IL (1) | IL172456A0 (de) |
IS (1) | IS8174A (de) |
NO (1) | NO20060145L (de) |
RS (1) | RS20050915A (de) |
WO (1) | WO2005000836A1 (de) |
ZA (1) | ZA200600294B (de) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MXPA03005140A (es) * | 2000-12-08 | 2004-10-15 | Johnson & Johnson | Compuestos de pirrolina sustituidos con indazolilo como inhibidores de cinasa. |
JP2005529918A (ja) * | 2002-05-08 | 2005-10-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換されたピロリンキナーゼ阻害剤 |
EP1513520B1 (de) * | 2002-06-05 | 2008-09-24 | Janssen Pharmaceutica N.V. | Substituierte pyrroline als kinase inhibitoren |
JP2006521386A (ja) * | 2003-03-27 | 2006-09-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤である置換ピロリン |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
EP1928437A2 (de) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenese mittels muscarinrezeptormodulation |
US20070088019A1 (en) * | 2005-09-29 | 2007-04-19 | Han-Cheng Zhang | Macroheterocyclic compounds as kinase inhibitors |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2382975A3 (de) | 2006-05-09 | 2012-02-29 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
KR101284836B1 (ko) | 2006-05-25 | 2013-07-10 | 삼성전자주식회사 | 이동통신시스템에서 자원 할당 맵 구성 방법 |
JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−2,4−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
WO2008037266A1 (en) * | 2006-09-25 | 2008-04-03 | Universite Libre De Bruxelles | Inhibitors of conventional protein kinase c isozymes and use thereof for treating inflammatory diseases |
JP2010513386A (ja) * | 2006-12-19 | 2010-04-30 | ノバルティス アーゲー | キナーゼ阻害剤としてのインドリルマレイミド誘導体 |
EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
EP2310372B1 (de) | 2008-07-09 | 2012-05-23 | Sanofi | Heterocyclische Verbindungen, Verfahren zu ihrer Herstellung, Arzneimitteln mit diesen Verbindungen und ihre Verwendung |
WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8785608B2 (en) | 2009-08-26 | 2014-07-22 | Sanofi | Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use |
WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2011157827A1 (de) | 2010-06-18 | 2011-12-22 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
ES2387359B1 (es) * | 2011-02-25 | 2013-08-01 | Consejo Superior De Investigaciones Científicas (Csic) | Inhibidores de GSK-3 útiles en enfermedades neurodegenerativas, inflamatorias, cáncer, diabetes y en procesos regenerativos |
US8710050B2 (en) | 2011-03-08 | 2014-04-29 | Sanofi | Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
EP2683700B1 (de) | 2011-03-08 | 2015-02-18 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
EP2683705B1 (de) | 2011-03-08 | 2015-04-22 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
WO2012120050A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
CN102344443A (zh) * | 2011-07-15 | 2012-02-08 | 南开大学 | 点击化学合成开环马来酰亚胺类化合物及其在治疗疾病中的应用 |
WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
CN103622964B (zh) * | 2013-12-04 | 2015-09-23 | 李强 | Trigolutesins A在治疗或预防急性心衰药物中的应用 |
US10220408B2 (en) * | 2016-09-12 | 2019-03-05 | The Boeing Company | Variable radius print head end effector |
CN108586432B (zh) * | 2018-05-31 | 2020-08-25 | 温州医科大学 | 一种3-(吲哚-5-基)-吲唑衍生物及其应用 |
US20220133740A1 (en) | 2019-02-08 | 2022-05-05 | Frequency Therapeutics, Inc. | Valproic acid compounds and wnt agonists for treating ear disorders |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ280738B6 (cs) * | 1988-02-10 | 1996-04-17 | F. Hoffmann - La Roche And Co., Aktiengesellschaft | Substituované pyrroly, jejich použití pro výrobu léčiv a léčiva na jejich bázi |
GB8904161D0 (en) * | 1989-02-23 | 1989-04-05 | Hoffmann La Roche | Substituted pyrroles |
US5624949A (en) * | 1993-12-07 | 1997-04-29 | Eli Lilly And Company | Protein kinase C inhibitors |
SE9603283D0 (sv) | 1996-09-10 | 1996-09-10 | Astra Ab | New compounds |
EP1120414A1 (de) | 1998-07-30 | 2001-08-01 | Japan Tobacco Inc. | Disubstituierte maleimidverbindungen und medizinische verwendung davon |
DE69922526T2 (de) | 1998-10-08 | 2005-06-02 | Smithkline Beecham Plc, Brentford | 3-(3-chloro-4-hydroxyphenylamino)-4-(2-nitrophenyl)-1h-pyrrol-2,5-dion als glykogen synthase kinase-3 inhibitor (gsk-3) |
MXPA03005140A (es) * | 2000-12-08 | 2004-10-15 | Johnson & Johnson | Compuestos de pirrolina sustituidos con indazolilo como inhibidores de cinasa. |
JP2005529918A (ja) * | 2002-05-08 | 2005-10-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 置換されたピロリンキナーゼ阻害剤 |
RU2004135382A (ru) * | 2002-06-05 | 2005-06-27 | Янссен Фармацевтика Н.В. (Be) | Замещенные пирролины в качестве ингибиторов киназы |
EP1513520B1 (de) * | 2002-06-05 | 2008-09-24 | Janssen Pharmaceutica N.V. | Substituierte pyrroline als kinase inhibitoren |
JP2006521386A (ja) * | 2003-03-27 | 2006-09-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | キナーゼ阻害剤である置換ピロリン |
-
2004
- 2004-06-01 JP JP2006533550A patent/JP2007500748A/ja not_active Withdrawn
- 2004-06-01 DE DE602004016174T patent/DE602004016174D1/de not_active Expired - Fee Related
- 2004-06-01 EP EP04754066A patent/EP1654255B1/de not_active Expired - Lifetime
- 2004-06-01 ES ES04754066T patent/ES2311161T3/es not_active Expired - Lifetime
- 2004-06-01 WO PCT/US2004/017375 patent/WO2005000836A1/en active Application Filing
- 2004-06-01 AU AU2004251178A patent/AU2004251178A1/en not_active Abandoned
- 2004-06-01 AT AT04754066T patent/ATE406365T1/de not_active IP Right Cessation
- 2004-06-01 KR KR1020057023946A patent/KR20060021890A/ko not_active Application Discontinuation
- 2004-06-01 CA CA002529353A patent/CA2529353A1/en not_active Abandoned
- 2004-06-01 US US10/858,212 patent/US7439363B2/en not_active Expired - Fee Related
- 2004-06-01 BR BRPI0411366-7A patent/BRPI0411366A/pt not_active IP Right Cessation
- 2004-06-01 CN CNA200480022892XA patent/CN1832940A/zh active Pending
- 2004-06-01 RS YUP-2005/0915A patent/RS20050915A/sr unknown
- 2004-06-01 EA EA200600032A patent/EA200600032A1/ru unknown
-
2005
- 2005-12-08 IL IL172456A patent/IL172456A0/en unknown
- 2005-12-09 IS IS8174A patent/IS8174A/is unknown
- 2005-12-13 CR CR8148A patent/CR8148A/es not_active Application Discontinuation
- 2005-12-13 EC EC2005006222A patent/ECSP056222A/es unknown
- 2005-12-13 HR HR20050991A patent/HRP20050991A2/xx not_active Application Discontinuation
- 2005-12-19 CO CO05127381A patent/CO5650246A2/es not_active Application Discontinuation
-
2006
- 2006-01-10 NO NO20060145A patent/NO20060145L/no not_active Application Discontinuation
- 2006-01-12 ZA ZA200600294A patent/ZA200600294B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CA2529353A1 (en) | 2005-01-06 |
CO5650246A2 (es) | 2006-06-30 |
ATE406365T1 (de) | 2008-09-15 |
HRP20050991A2 (en) | 2006-09-30 |
ZA200600294B (en) | 2007-04-25 |
WO2005000836A1 (en) | 2005-01-06 |
NO20060145L (no) | 2006-03-07 |
IS8174A (is) | 2005-12-09 |
US20050004201A1 (en) | 2005-01-06 |
CR8148A (es) | 2008-09-10 |
CN1832940A (zh) | 2006-09-13 |
IL172456A0 (en) | 2006-04-10 |
US7439363B2 (en) | 2008-10-21 |
KR20060021890A (ko) | 2006-03-08 |
ES2311161T3 (es) | 2009-02-01 |
BRPI0411366A (pt) | 2006-07-25 |
EP1654255A1 (de) | 2006-05-10 |
ECSP056222A (es) | 2006-04-19 |
JP2007500748A (ja) | 2007-01-18 |
RS20050915A (sr) | 2008-04-04 |
EA200600032A1 (ru) | 2006-06-30 |
EP1654255B1 (de) | 2008-08-27 |
AU2004251178A1 (en) | 2005-01-06 |
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