PE20081368A1 - Derivados de azabiciclo[4.1.0]heptano como inhibidores de la recaptacion de serotonina, dopamina y norepinefrina - Google Patents
Derivados de azabiciclo[4.1.0]heptano como inhibidores de la recaptacion de serotonina, dopamina y norepinefrinaInfo
- Publication number
- PE20081368A1 PE20081368A1 PE2007001202A PE2007001202A PE20081368A1 PE 20081368 A1 PE20081368 A1 PE 20081368A1 PE 2007001202 A PE2007001202 A PE 2007001202A PE 2007001202 A PE2007001202 A PE 2007001202A PE 20081368 A1 PE20081368 A1 PE 20081368A1
- Authority
- PE
- Peru
- Prior art keywords
- azabicycle
- group
- heptane
- recaptation
- norepinephrine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Virology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Hospice & Palliative Care (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pregnancy & Childbirth (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE AZABICICLO[4.1.0]HEPTANO DE FORMULA (A), EN DONDE R1 ES H O ALQUILO(C1-C4); R2 ES UN GRUPO A, K O W; DONDE A ES UN GRUPO DE FORMULA a); K ES UN GRUPO a O ß NAFTILO OPCIONALMENTE SUSTITUIDO POR R18; W ES DE FORMULA b), EN DONDE G ES HETEROARILO MONO O BICICLICO OPCIONALMENTE SUSTITUIDO CON (R15)p; R3 Y R4 SON INDEPENDIENTEMENTE H, F Y ALQUILO(C1-C4) O UN GRUPO X O X1; R5 Y R17 SON INDEPENDIENTEMENTE H O ALQUILO(C1-C4); R7 ES R5 O UN GRUPO X, X1, X2 O X3; DONDE X ES -(CH2)n-O-R16; X1 ES -(CH2)n-O-R19; X2 ES -CO-OR19; Y X3 ES -CO-NH2. SON SELECCIONADOS: (1S,6R/1R,6S)-6-(3,4-DICLOROFENIL)-1-[(METILOXI)METIL]-3-AZABICICLO[4.1.0]HEPTANO, [(1S,6R/1R,6S)-6-(3,4-DICLOROFENIL)-3-AZABICICLO[4.1.0]HEPT-1-IL]METANOL. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON INHIBIDORES DE LA RECAPTACION DE SEROTONINA (5-HT), DOPAMINA (DA) Y NOREPINEFRINA (NE), SIENDO UTILES EN EL TRATAMIENTO DE LA DEPRESION
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0617868A GB0617868D0 (en) | 2006-09-11 | 2006-09-11 | Chemical compounds |
GB0617863A GB0617863D0 (en) | 2006-09-11 | 2006-09-11 | Chemical compounds |
GB0716371A GB0716371D0 (en) | 2007-08-22 | 2007-08-22 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081368A1 true PE20081368A1 (es) | 2008-11-19 |
Family
ID=38561834
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2007001202A PE20081368A1 (es) | 2006-09-11 | 2007-09-07 | Derivados de azabiciclo[4.1.0]heptano como inhibidores de la recaptacion de serotonina, dopamina y norepinefrina |
Country Status (19)
Country | Link |
---|---|
US (2) | US7691893B2 (es) |
EP (1) | EP2064186A1 (es) |
JP (1) | JP4448198B2 (es) |
KR (1) | KR20090064447A (es) |
AR (1) | AR062737A1 (es) |
AU (1) | AU2007296301A1 (es) |
BR (1) | BRPI0716532A2 (es) |
CA (1) | CA2662538A1 (es) |
CL (1) | CL2007002619A1 (es) |
CO (1) | CO6150149A2 (es) |
CR (1) | CR10671A (es) |
EA (1) | EA200970266A1 (es) |
IL (1) | IL197297A0 (es) |
MA (1) | MA30767B1 (es) |
MX (1) | MX2009002625A (es) |
NO (1) | NO20091099L (es) |
PE (1) | PE20081368A1 (es) |
TW (1) | TW200826934A (es) |
WO (1) | WO2008031772A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0716532A2 (pt) | 2006-09-11 | 2013-09-24 | Glaxo Group Ltd | compostos azabicÍclios como inidores de reabsorÇço de monoaminas |
GB0716573D0 (en) * | 2007-08-24 | 2007-10-03 | Glaxo Group Ltd | Chemical compounds |
GB0804326D0 (en) * | 2008-03-07 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
WO2010125033A1 (en) * | 2009-04-29 | 2010-11-04 | Glaxo Group Limited | Azabicyclo[4.1.0]heptane derivatives |
WO2010130672A1 (en) * | 2009-05-12 | 2010-11-18 | Glaxo Group Limited | Azabicyclo [4.1.0] heptane derivatives and their use as monoamine reuptake inhibitors |
WO2010133569A1 (en) * | 2009-05-20 | 2010-11-25 | Glaxo Group Limited | Azabicyclo[4.1.0]heptane derivatives |
WO2010146025A1 (en) * | 2009-06-17 | 2010-12-23 | Glaxo Group Limited | Tricyclic azabicyclo [4.1.0] heptane derivatives as inhibitors of serotonin, dopamine and norepinephrine re-uptake |
SI2626350T1 (sl) | 2010-09-22 | 2015-09-30 | Eisai R&D Management Co., Ltd. | Spojina ciklopropana |
DE102011100831A1 (de) | 2011-05-07 | 2012-11-08 | Studiengesellschaft Kohle Mbh | Verfahren zur Herstellung von GSK 1360707 und verwandter Verbindungen mit 6-Aryl-1-[(alkyloxy) alkyl]-3-azabicyclo[4.1.0]heptan Grundgerüst |
WO2016063995A1 (en) | 2014-10-23 | 2016-04-28 | Eisai R&D Management Co., Ltd. | Compositions and methods for treating insomnia |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2008A (en) * | 1841-03-18 | Gas-lamp eok conducting gas pkom ah elevated buhner to one below it | ||
US2004A (en) * | 1841-03-12 | Improvement in the manner of constructing and propelling steam-vessels | ||
US4131611A (en) | 1975-07-31 | 1978-12-26 | American Cyanamid Company | Azabicyclohexanes |
US4435419A (en) | 1981-07-01 | 1984-03-06 | American Cyanamid Company | Method of treating depression using azabicyclohexanes |
AU672644B2 (en) * | 1992-12-23 | 1996-10-10 | Neurosearch A/S | Aryl substituted heterocyclic compounds |
ES2159839T3 (es) | 1996-02-22 | 2001-10-16 | Neurosearch As | Derivados del propano, su preparacion y su uso. |
ES2329739T3 (es) * | 1997-04-07 | 2009-11-30 | Georgetown University | Analogos de cocaina. |
US6303627B1 (en) * | 1998-06-19 | 2001-10-16 | Eli Lilly And Company | Inhibitors of serotonin reuptake |
US6372919B1 (en) * | 2001-01-11 | 2002-04-16 | Dov Pharmaceutical, Inc. | (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent |
US6569887B2 (en) | 2001-08-24 | 2003-05-27 | Dov Pharmaceuticals Inc. | (−)-1-(3,4-Dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as a dopamine-reuptake |
US20060173064A1 (en) | 2001-08-24 | 2006-08-03 | Lippa Arnold S | (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders |
DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
EP1735302B1 (en) * | 2004-02-27 | 2010-06-16 | Eli Lilly And Company | 4-amino-piperidine derivatives as monoamine uptake inhibitors |
BRPI0716532A2 (pt) | 2006-09-11 | 2013-09-24 | Glaxo Group Ltd | compostos azabicÍclios como inidores de reabsorÇço de monoaminas |
-
2007
- 2007-09-07 BR BRPI0716532-3A2A patent/BRPI0716532A2/pt not_active IP Right Cessation
- 2007-09-07 CA CA002662538A patent/CA2662538A1/en not_active Abandoned
- 2007-09-07 AU AU2007296301A patent/AU2007296301A1/en not_active Abandoned
- 2007-09-07 EA EA200970266A patent/EA200970266A1/ru unknown
- 2007-09-07 WO PCT/EP2007/059381 patent/WO2008031772A1/en active Application Filing
- 2007-09-07 US US11/851,459 patent/US7691893B2/en not_active Expired - Fee Related
- 2007-09-07 US US12/440,852 patent/US20100035914A1/en not_active Abandoned
- 2007-09-07 PE PE2007001202A patent/PE20081368A1/es not_active Application Discontinuation
- 2007-09-07 KR KR1020097007365A patent/KR20090064447A/ko not_active Application Discontinuation
- 2007-09-07 MX MX2009002625A patent/MX2009002625A/es unknown
- 2007-09-07 JP JP2009527793A patent/JP4448198B2/ja not_active Expired - Fee Related
- 2007-09-07 EP EP07803326A patent/EP2064186A1/en not_active Withdrawn
- 2007-09-10 CL CL200702619A patent/CL2007002619A1/es unknown
- 2007-09-10 TW TW096133638A patent/TW200826934A/zh unknown
- 2007-09-11 AR ARP070104006A patent/AR062737A1/es not_active Application Discontinuation
-
2009
- 2009-02-26 IL IL197297A patent/IL197297A0/en unknown
- 2009-03-10 CO CO09024346A patent/CO6150149A2/es unknown
- 2009-03-13 NO NO20091099A patent/NO20091099L/no not_active Application Discontinuation
- 2009-03-19 CR CR10671A patent/CR10671A/es not_active Application Discontinuation
- 2009-03-30 MA MA31737A patent/MA30767B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
EP2064186A1 (en) | 2009-06-03 |
WO2008031772A1 (en) | 2008-03-20 |
US20080114049A1 (en) | 2008-05-15 |
CA2662538A1 (en) | 2008-03-20 |
CL2007002619A1 (es) | 2008-04-18 |
US7691893B2 (en) | 2010-04-06 |
IL197297A0 (en) | 2009-12-24 |
CO6150149A2 (es) | 2010-04-20 |
JP2010502761A (ja) | 2010-01-28 |
AR062737A1 (es) | 2008-11-26 |
MA30767B1 (fr) | 2009-10-01 |
NO20091099L (no) | 2009-04-03 |
CR10671A (es) | 2009-04-29 |
JP4448198B2 (ja) | 2010-04-07 |
MX2009002625A (es) | 2009-03-24 |
AU2007296301A1 (en) | 2008-03-20 |
EA200970266A1 (ru) | 2009-08-28 |
US20100035914A1 (en) | 2010-02-11 |
BRPI0716532A2 (pt) | 2013-09-24 |
KR20090064447A (ko) | 2009-06-18 |
TW200826934A (en) | 2008-07-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20081368A1 (es) | Derivados de azabiciclo[4.1.0]heptano como inhibidores de la recaptacion de serotonina, dopamina y norepinefrina | |
PH12017501192B1 (en) | Certain amino-pyridazines, compositions thereof, and methods of their use | |
PE20091376A1 (es) | Derivados de fenilamino como moduladores de beta-amiloide | |
PE20130375A1 (es) | Compuestos de triazolopiridinas y triazolopirazinas inhibidores de c-met y composiciones de los mismos | |
MY163498A (en) | Certain amino-pyrimidines, compositions thereof, and methods for their use | |
EA201000484A1 (ru) | Тиенопиримидиновые и пиразолопиримидиновые соединения и их применение в качестве ингибиторов киназы mtor и киназы pi3 | |
DOP2005000071A (es) | "compuestos de metil-aril o heteroaril-amida sustituida" | |
EA201001682A1 (ru) | Производные фенил- и бензодиоксинилзамещенных индазолов | |
TW200639158A (en) | New compounds with therapeutic effect | |
EA201001669A1 (ru) | Замещенные пиримидин-5-карбоксамиды 281 | |
EA200970856A1 (ru) | Ингибиторы пути хеджхога | |
DE602006006850D1 (de) | Als modulatoren von dopamin-d3-rezeptoren geeignete azabicyclo-(3,1,0)-hexan-derivate | |
BRPI0809656B8 (pt) | atropisômero, composto, agente profilático ou terapêutico, e, composição farmacêutica | |
PE20070491A1 (es) | Compuestos derivados de 9-azabiciclo[3.3.1]nonano como inhibidores de la recaptacion de neurotransmisores de monoamina | |
UA99447C2 (ru) | Способ получения силденафила | |
ATE484502T1 (de) | Neue verbindungen | |
EA200970793A1 (ru) | Модуляторы рецепторов, активируемых пролифераторами пероксисом | |
EA201200602A1 (ru) | Индазолы и пиразолопиридины в качестве антагонистов рецептора ccr1 | |
EA201490722A1 (ru) | ПРОИЗВОДНЫЕ ЭТИНИЛА В КАЧЕСТВЕ АЛЛОСТЕРИЧЕСКИХ МОДУЛЯТОРОВ МЕТАБОТРОПНОГО РЕЦЕПТОРА ГЛУТАМАТА mGluR5 | |
PE20081831A1 (es) | Derivados de heteroaril-pirrolidinil- y -piperidinil-cetona | |
AR074801A1 (es) | Monocarbamas y composiciones farmaceuticas que los contienen | |
MX2009011922A (es) | Tetrahidrobenzazepinas ariloxi- y heteroariloxi-sustituidas y uso de las mismas para bloquear reabsorcion de norepinefrina, dopamina y serotonina. | |
EA201100350A1 (ru) | Противогрибковые средства | |
DE602005014629D1 (de) | Pyrazolphenylderivate als ppar-aktivatoren | |
BRPI0513083A (pt) | oxazolidinonas contendo oxindóis como agentes antibacterianos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |